Pinned
Talking with HS students from the Mission Bay Hub about obesity and curiosity-driven science. With help from @TruongLy18 and an ob/ob mouse. @SFUnified
Zachary Knight
694 posts
Zachary Knight
@zaknight
The Neurobiology of Homeostasis.
- Often people will say, X food or activity increases GLP1, but in this Huberman Lab episode out now @zaknight explains why enormous increases in GLP1 are necessary for weight loss; increases that pharmacology alone can produce. It’s also a master class in the control of hunger.
- Claim that any food is a "natural ozempic" is nonsense. We know this because the semaglutide concentration required for weight loss is 1000x higher than endogenous Glp1 levels regardless of what you eat.Nature's Ozempic: Cocoa and Extra Virgin Olive Oil We constructed the Blueprint stack with high amounts of polyphenols and fibre, which may boost 'natural ozempic production' in the gut. "Specialized bacteria in your lower gut take the components of food you can’t digest like
- Our soma-targeted GCaMPs for worms and mice are now available from @Addgene. If you recently emailed me or @jenngarrison - thank you for your patience! addgene.org/browse/article…
- Big congratulations to Tara Aitken, who defended her thesis today and gave an amazing seminar describing how different kinds of sensory cues are used for appetite regulation.
- New work from the lab developed and driven by the incredibly talented @James_CR_Grove. Congrats James!!I’m excited to share that our paper is online today in @Nature. We investigate how animals learn what foods and fluids hydrate them. Sincere thanks to my mentor @zaknight and thanks to collaborators @berke_lab and @AnatolKreitzer. (1/6) nature.com/articles/s4158…
- I just got a bill from a UCSF core stating that my lab has been using one microscope for 90 hours *per day*. I wish this was possible/true.
- I had no idea how lucky I was when Chris and Yiming joined the lab. From the beginning it was just one exciting discovery after another. Congrats on the Weintraub award guys – you both deserve it so much.
- This new study by Tara Aitken shows that taste cues regulate AgRP neurons, and their inputs in the DMH, during ingestion. This gustatory feedback controls the timing of meal termination, linking the dynamics of AgRP neurons during feeding to the control of behavior.Negative feedback control of hunger circuits by the taste of food biorxiv.org/cgi/content/sh… #bioRxiv
- Impressive new study from @ZimmermanNeuro shows that visceral malaise reactivates the representation of recently consumed flavors, providing a mechanism for post-ingestive learning.
- I'm convinced this is the reason for most opposition to weight loss medications - it's about loss of social statusThis theory makes a lot of sense to me. The reason some thin people are making moral arguments against GLP-1s is that, on some level, they think the drugs degrade the status signal of being lean (that they benefit from).
- Nice write-ups about @TruongLy18's new paper, with comments from Nick Betley, Haijiang Cai, @LuckmanLab, @LoraHeisler, and @_Chen_Ran_. Science: shorturl.at/oNX08 Nature: shorturl.at/beszR UCSF: shorturl.at/pqMPW @UCSF @HHMINEWS
- Congratulations David and Chris on a beautiful paper! cell.com/neuron/fulltex…
