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Stephan J. Guyenet
@sguyenet
The neuroscience of eating behavior and obesity. Author of The Hungry Brain. Founder and director of Red Pen Reviews. Neuroscience PhD, University of WA.
Seattle, WA
stephanguyenet.com
Joined April 2011
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  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Jan 7, 2019
    Big announcement. Joe Rogan has graciously invited Gary Taubes and I to debate on his podcast. March 19. To my knowledge, this will be the first time Taubes has publicly live debated an obesity researcher who is familiar with his work. @joerogan @garytaubes
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Jun 6, 2025
    More evidence that the strong correlation between physical fitness and risk of death is heavily confounded by genetics and other factors. This is a tough one for the preventive health community (including me)!
    190K
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    May 31, 2024
    We now have two large, convincing randomized controlled trials reporting that replacing regular salt with potassium-enriched salt substitute (~75% NaCl, 25% KCl) reduces cardiovascular events and probably all-cause mortality. doi.org/10.1056/nejmoa… doi.org/10.1038/s41591…
    nejm.org
    Effect of Salt Substitution on Cardiovascular Events and Death | NEJM
    Salt substitutes with reduced sodium levels and increased potassium levels have been shown to lower blood pressure, but their effects on cardiovascular and safety outcomes are uncertain. We conduct...
    199K
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Mar 11, 2022
    This is the "low-fat diet" that supposedly caused the US obesity epidemic
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Mar 12, 2020
    People who don't think coronavirus is a big deal are about to learn something about exponential growth
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Mar 7, 2019
    March 19. Mark your calendars. Are you excited? I am. @joerogan @garytaubes
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Nov 25, 2019
    I'm continually amazed by people who seem to know exactly what our Paleolithic ancestors ate, when actual archaeologists have a lot of uncertainty about it.
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Jan 17, 2020
    I was very disappointed to read this article describing attempts by the True Health Initiative to suppress the series of meta-analyses on red meat that was recently published in Annals of Internal Medicine. As a result of this, I've cut my ties with THI.
    Conflicts of Interest in Nutrition Research
    From jamanetwork.com
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Apr 9, 2020
    And there it is. COVID-19 is now the leading cause of death in the US. public.flourish.studio/visualisation/…
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Sep 14, 2018
    Here is a graph I created, using @bigfatsurprise logic, illustrating how the low-carbohydrate diet accelerated the US obesity epidemic. It's just as unconvincing as the argument that government diet advice caused it.
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Mar 8, 2021
    Let's talk about potatoes. It's commonly accepted that potatoes are unhealthy, or at least less healthy than certain other starches like whole grains. I'm not convinced.
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Jan 13, 2022
    Back in my early blogging days, one of my soapbox issues was that dietary saturated fat is probably harmless. My views on that have evolved over the years and it's time for me to share the update.
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Oct 8, 2024
    This theory makes a lot of sense to me. The reason some thin people are making moral arguments against GLP-1s is that, on some level, they think the drugs degrade the status signal of being lean (that they benefit from).
    user avatar
    Chris Williamson
    @ChrisWillx
    Oct 7, 2024
    The debate behind Ozempic.
    74K
  • user avatar
    Stephan J. Guyenet
    @sguyenet
    Mar 6, 2023
    This article is one of the more important things I've written. It's about nutrition misinformation. ▶️What it is ▶️How widespread it is ▶️Where it comes from ▶️Why people believe it ▶️How, and how much, it harms us asteriskmag.com/issues/2/read-…
    205K