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Tony Wyss-Coray
@wysscoray
Joined January 2017
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  • user avatar
    Tony Wyss-Coray
    @wysscoray
    Feb 20, 2022
    Imagine we developed a drug to repair synapses and neurons and learned that the supply routes keeping neurons alive are broken in AD brains - it’s a possibility. Check out @andcyang ’s human brain vascular atlas rdcu.be/cGZ2D and the related study from Heiman/Kellis
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    Tony Wyss-Coray
    @wysscoray
    Jul 15, 2020
    Biologic & disease processes need to be viewed from an age perspective. How does your favorite gene change with age? check out Tabula Muris Senis and this App combining sc and bulkRNAseq across 10 ages twc-stanford.shinyapps.io/maca/ in rdcu.be/b5DqF and rdcu.be/b5DqD
  • user avatar
    Tony Wyss-Coray
    @wysscoray
    Jun 20, 2022
    excited to share an in-depth review of aging clocks or-more appropriate-methods to estimate biological age rdcu.be/cPR6u. Congratulations to Jarod Rutledge and Hamilton @hammy_oh
  • user avatar
    Tony Wyss-Coray
    @wysscoray
    Aug 17, 2023
    Aging is key to Neurodegeneration but the spatiotemporal contribution of genes to disease susceptibility (regional vulnerability) or progression is unknown. @Oliver__Hahn and team captured gene expression changes across brain regions and mouse lifespan doi.org/10.1016/j.cell…
    49K
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    Tony Wyss-Coray
    @wysscoray
    Jan 8, 2020
    Congratulations to David Gate and all our fantastic collaborators! An immune-cell signature marks the brain in Alzheimer’s disease nature.com/articles/d4158…
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    Tony Wyss-Coray
    @wysscoray
    Apr 28, 2022
    I'm thrilled and humbled to direct the Phil and Penny Knight Initiative for Brain Resilience news.stanford.edu/2022/04/26/sta… at the Stanford Wu Tsai Neuro and work towards eradicating age-related cognitive decline and dementia. Thanks for the amazing gift and to all who made it happen
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    Tony Wyss-Coray
    @wysscoray
    Jul 1, 2020
    Very excited to share work of Andrew Yang, supported by a fantastic team and productive collaborations with @mjameslab and @CarolynBertozzi: rdcu.be/b5mi1 Brain blood vessels soak up blood proteins defying barrier stigma. Thanks for a wonderful review by Rich Daneman!!
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    Tony Wyss-Coray
    @wysscoray
    Dec 9, 2021
    Exercise is in your blood – I’m so happy for Zuri DeMiguel to get this amazing study out against all odds. With tremendous help from Nathalie Khoury, Mike Betley, Benoit Lehallier @blehall &collaborators Kaci Fairchild &Tom Rando nature.com/articles/s4158…
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    Tony Wyss-Coray
    @wysscoray
    Jan 9, 2020
    We find granzyme positive CD8 T cells next to degenerating neurons in hippocampi of Alzheimer’s patients. A smoking gun and a dead body but more work will be needed to prove that that gun killed the neuron. More here nature.com/articles/s4158… and here …g-stanford-edu.laneproxy.stanford.edu/2020/01/08/sus…
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    Tony Wyss-Coray
    @wysscoray
    Dec 17, 2023
    How can we slow aging or rejuvenate brains and other organs without having biomarkers to test interventions? @JarodRutledge1 and @hammy_oh may have a solution tinyurl.com/2wzxkrck. Congrats and thanks to these superstars and to all for this massive effort!
    18K
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    Tony Wyss-Coray
    @wysscoray
    Apr 29, 2021
    and here is our simple web browser developed by Patricia Losada to look up the expression of your favorite gene in the human brain vasculature and in AD twc-stanford.shinyapps.io/human_bbb/
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    Tony Wyss-Coray
    @wysscoray
    Sep 21, 2019
    Excited to share Zurine DeMiguel’s study from our lab showing plasma from exercised mice transferred into sedentary ones, reduces brain inflammation and improves cognitive function! The complement and coagulation systems seem to have a key role in this:
    biorxiv.org
    Exercise conditioned plasma dampens inflammation via clusterin and boosts memory
    Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation...
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    Tony Wyss-Coray
    @wysscoray
    Jan 21, 2020
    Great collaboration with @carolynbertozzi, Michael Bassik, and Ludwig Aigner lead to this cool discovery by Julia Marschallinger suggesting lipid droplets in microglia may have a critical role in aging and neurodegeneration nature.com/articles/s4159…
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    Tony Wyss-Coray
    @wysscoray
    Sep 22, 2022
    We have little molecular data how complex brains age across regions. Check out study from @Oliver__Hahn with app to query how your favorite gene changes region specific. Major implication for risk and resilience to cognitive decline and degeneration tinyurl.com/2j8detej