Hamilton Oh (@hammy

Hamilton Oh

241 posts

Hamilton Oh

@hammy_oh

Postdoc, Leon Levy Neuroscience Fellow @ScottRussoPhD @IcahnMountSinai | PhD @wysscoray @Stanford | Brain-Body | Aging and Alzheimer's | Proteomic biomarkers

New York City

Joined July 2018

Pinned
Hamilton Oh
@hammy_oh
Jul 9, 2025
I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12 🔗
Plasma proteomics links brain and immune system aging with healthspan and longevity
From nature.com
62K
Hamilton Oh
@hammy_oh
Dec 6, 2023
I am thrilled to present our new study out in @Nature where we measure aging at organ-level resolution in living people with large-scale plasma proteomics + ML! From @wysscoray lab, co-led with former grad student @JarodRutledge1 1/12
205K
Hamilton Oh
@hammy_oh
Mar 31, 2025
I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12 Full study 🔗:
nature.com
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus...
Nature Medicine - The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals...
74K
Hamilton Oh
@hammy_oh
Jun 20, 2022
Excited to share our comprehensive review on measuring biological age out in @NatureRevGenet, written by Jarod, me, and @wysscoray! We hope to see the field focus on measuring aging factors related to human physiology and health. Check out the full text rdcu.be/cPR6u
Hamilton Oh
@hammy_oh
Feb 26, 2025
Absolutely beautiful study from old lab mate and friend @sophmshi! Key sugars in the blood brain barrier (BBB) lumen are lost with age, leading to increased BBB leakiness and cognitive decline!
Sophia Shi
@sophmshi
Feb 26, 2025
Excited to share our new study in @Nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A @wysscoray & @CarolynBertozzi labs collaboration. 🍭🧠 #glycotime (1/12) nature.com/articles/s4158…
34K
Hamilton Oh
@hammy_oh
Jul 26, 2024
I'm excited to share 2 of our new studies now out as preprints on BioRxiv! biorxiv.org/content/10.110… biorxiv.org/content/10.110… From @wysscoray lab in collaboration with many amazing groups including... 1/5
biorxiv.org
Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan...
Organ-derived plasma protein signatures derived from aptamer protein arrays track organ-specific aging, disease, and mortality in humans, but the robustness and clinical utility of these models and...
14K
Hamilton Oh
@hammy_oh
Dec 6, 2023
Replying to @hammy_oh
Full text here nature.com/articles/s4158… All organ aging models can be easily tested on SomaScan data using github.com/hamiltonoh/org…. Change with age information of 5,000 proteins in plasma twc-stanford.shinyapps.io/aging_plasma_p…
Organ aging signatures in the plasma proteome track health and disease
From nature.com
5.6K
Hamilton Oh
@hammy_oh
Dec 8, 2023
Amazing thread by my co-first author, Jarod, detailing the various and important clinical implications of our work. Check it out!
Jarod Rutledge
@JarodRutledge1
Dec 8, 2023
I’m proud to share my new research in @Nature this week, co-led by @hammy_oh, where we develop blood tests to track how your organs age! “But Jarod, why should I care? What can we really do with this?” Here are 3 ways we think this will be useful in science and medicine! 1/10
3.4K
Hamilton Oh
@hammy_oh
Dec 6, 2023
Replying to @hammy_oh
Regarding the brain, traditionally thought to be inaccessible due to the blood brain barrier, we found that having an older brain based on the levels of neuronal/glial proteins was associated with Alzheimer’s disease, independent of gold-standard Alzheimer’s biomarkers. 11/12
2.8K
Hamilton Oh
@hammy_oh
Dec 6, 2023
Replying to @hammy_oh
We measured the levels of ~5,000 proteins in plasma from ~5,700 individuals across five independent cohorts. From these 5k proteins, we identified ~900 organ-specific proteins, surprisingly many from the brain, based on their high organ-specificity at the RNA level. 6/12
4K
Hamilton Oh
@hammy_oh
Dec 6, 2023
Replying to @hammy_oh
Overall, we believe these results have enormous implications for monitoring health and treating/preventing age-related diseases, as we find there are all kinds of agers in the population. ~1/5 “healthy” people in our study have an organ that is especially aged! 12/12
3.4K
Hamilton Oh
@hammy_oh
Dec 6, 2023
Replying to @hammy_oh
We set out to study human aging with this perspective, as different aging rates between organs within an individual would suggest different levels of risk for various age-related diseases (ie. heart failure, dementia, chronic liver disease). 4/12
3.5K
Hamilton Oh
@hammy_oh
Dec 6, 2023
Replying to @hammy_oh
We found this to be true! Nearly all organ age gaps were predictive of mortality, with the strongest associations coming from the organismal and heart age gaps. This was great to see as multi-morbidity and heart disease are the primary causes of death in people. 9/12
2.9K
Hamilton Oh
@hammy_oh
Jul 27, 2025
I'll be presenting this work and new unpublished work tomorrow 9am ET at AAIC. Also presenting a poster in the Monday session, poster #102349. Hope to see you there!
Hamilton Oh
@hammy_oh
Mar 31, 2025
I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…
1.3K