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Ed Chouchani
@echouchani
Faculty @DanaFarber @harvardmed @HHMINEWS Co-founder @matchpointtx
Boston, MA
chouchanilab.dana-farber.org
Joined July 2013
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  • user avatar
    Ed Chouchani
    @echouchani
    Mar 15, 2023
    Our work on the discovery of a biochemical mechanism through which lactate regulates protein function, cell cycle, and proliferation, is out today in @nature. Congrats to lead authors Weihai, Yun, @luiz_bozi & Patrick! A 🧵 @HarvardCellBio @DanaFarber
    Content cover image
    Lactate regulates cell cycle by remodelling the anaphase promoting complex
    From nature.com
    81K
  • user avatar
    Ed Chouchani
    @echouchani
    Sep 17, 2020
    Excited to share our new paper in @CellCellPress today, describing a pH-sensing metabolite signal that regulates the muscle response to exercise. Great collaboration w @DanaFarber @harvardmed Mathis lab @GygiLab @proferikrichter !
    pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise
    From cell.com
  • user avatar
    Ed Chouchani
    @echouchani
    Jul 23, 2024
    I am thrilled and honored to join the @HHMINEWS community. So grateful to my lab, colleagues at @DanaFarber @HarvardCellBio, and collaborators whose work this reflects!
    32K
  • user avatar
    Ed Chouchani
    @echouchani
    Apr 28, 2022
    Why succinate? In this new paper, Mike Murphy and I outline the bioenergetic logic that explains why this metabolite has evolved to regulate a broad range of physiological processes. Check it out! @MRC_MBU @HarvardCellBio @DanaFarber @nchembio nature.com/articles/s4158…
  • user avatar
    Ed Chouchani
    @echouchani
    Dec 2, 2021
    Our paper is out in @Cell_Metabolism! In it we examine the physiological relevance of the redox regulatory site on the major thermogenic protein UCP1, which uncovers a newfound role in sex-dependent metabolic tissue inflammation! @harvardmed @DanaFarber tinyurl.com/bdd6nzbp
  • user avatar
    Ed Chouchani
    @echouchani
    May 17, 2021
    Excited to share our new paper in @NatMetabolism, the latest chapter of the succinate saga, led by rockstar post-doc @evanna_mills. A great collaboration with @lynchielydia, @GygiLab, @DanaFarber, @HarvardCellBio. Some highlights: rdcu.be/ckK9y
  • user avatar
    Ed Chouchani
    @echouchani
    Feb 20, 2024
    nature.com/articles/s4225… Excited to share our new paper on the discovery of MCT1 as a mediator of succinate uptake into brown adipocytes. We propose local plasma membrane pH gradients regulate systemic regulation by succinate.
    33K
  • user avatar
    Ed Chouchani
    @echouchani
    Feb 27, 2020
    Our Oximouse paper is online today! We developed a new MS approach for the first quantitative tissue-specific landscape of protein redox regulation in living tissues. Great collaboration with many: @GygiLab Gray Lab @DFCI_ChemBio @HarvardCellBio, thread:
    A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
    From cell.com
  • user avatar
    Ed Chouchani
    @echouchani
    Nov 4, 2022
    OPABAT is out today in @CellCellPress! We developed a proteomic approach for outbred mice to: 1) Nominate co-operative functions for thousands of understudied proteins. 2) Identify conserved regulators of physiology in brown adipose tissue. A thread:
    Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
    From cell.com
  • user avatar
    Ed Chouchani
    @echouchani
    Feb 23, 2023
    Very excited to share our study published today in @nchembio. We developed a first-in-class covalent inhibitor for creatine kinases, using chemoproteomics to target a conserved active site cysteine. nature.com/articles/s4158…
    42K
  • user avatar
    Ed Chouchani
    @echouchani
    Jul 18, 2018
    Our labs first paper is out today! Describes succinate as an activator of adipose tissue thermogenesis, and its remarkable effects on mouse metabolism. nature.com/articles/s4158… Great collaboration! @DanaFarber @HarvardCellBio @broadinstitute @Bankslab @HaigisLab @MRC_MBU @UCSF
    nature.com
    Accumulation of succinate controls activation of adipose tissue thermogenesis
    Nature - A comparative metabolomics approach is used to identify succinate as a key activator of thermogenesis in brown adipose tissue.
  • user avatar
    Ed Chouchani
    @echouchani
    Oct 18, 2022
    Honored to receive a @Vilcek Foundation Prize, recognizing the research from my amazing lab members & colleagues at @DanaFarber @HarvardCellBio
    user avatar
    The Vilcek Foundation
    @Vilcek
    Oct 18, 2022
    🧬Since 2006, we have awarded the @Vilcek Foundation Prizes in #Biomedical #Science to #immigrant #scientists whose work has a profound impact on biomedical research and medicine. Meet our 2023 Prizewinners: @Planaria1, @echouchani, @InLiuOfBulkExps. vilcek.co/2023vfpbioton
  • user avatar
    Ed Chouchani
    @echouchani
    Aug 16, 2023
    We're looking for a new Assistant Professor @DanaFarber & @HarvardCellBio! This is a very special research environment and starting my lab here has been an exceptional experience. Come join us!!
    user avatar
    Dana-Farber
    @DanaFarber
    Aug 16, 2023
    Dana-Farber is #NowHiring an Assistant Professor #HealthEducator #HealthcareCareer #DanaFarber Apply Here: ms.spr.ly/60179M8pb
    47K
  • user avatar
    Ed Chouchani
    @echouchani
    Jul 16, 2022
    We have a new faculty search at @HarvardCellBio!! Feel free to DM or e-mail me if you have any questions about the department. @HarvardCellBio has a wonderful group of colleagues and is a great place to start a lab! academicpositions.harvard.edu/postings/11447