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Nature Chemical Biology
@nchembio
A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
New York, USA
nature.com/nchembio
Joined March 2009
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    Nature Chemical Biology
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    Jun 2
    Our June issue is live with a focus on RNA chemical biology nature.com/nchembio/volum… The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark
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    Nature Chemical Biology
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    Oct 31, 2022
    A new paper from Kai Johnsson’s group developed a biosensor for visualizing cytosolic and mitochondrial CoA in living cells. Open access:
    Content cover image
    Probing coenzyme A homeostasis with semisynthetic biosensors
    From nature.com
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    Nature Chemical Biology
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    Dec 12, 2022
    A new paper from Brian Kuhlman and @BowersRangers used computational protein design to place a substrate recruitment domain adjacent to an active site increasing the specificity of a promiscuous enzyme by 1000-fold. Free to read: rdcu.be/c1tza nature.com/articles/s4158…
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    Nature Chemical Biology
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    Sep 9, 2024
    Engineering artificial non-coding RNAs for targeted protein degradation. Read it here rdcu.be/dTsjJ
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    Nature Chemical Biology
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    Mar 29, 2022
    Our April cover (nature.com/nchembio/volum…) features a portrait of Rosalind Franklin generated by the biosensor platform ROSALIND (‘RNA outputs activated by ligand induction’), developed by @LucksLab (nature.com/articles/s4158…)
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    Nature Chemical Biology
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    Nov 18, 2023
    A new paper from @JaffreyLab reveals that phospholipids can partition into protein condensates depending on the length of their acyl moiety and influence the properties of the condensates. Free to read link at rdcu.be/drmNe
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    Nature Chemical Biology
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    Dec 30, 2021
    The Tan and Scheinberg laboratories from @sloan_kettering report SEAKER, an approach that equips CAR-T cells to express enzymes that release prodrugs at tumor sites. Free to read: rdcu.be/cD6GR nature.com/articles/s4158…
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    Nature Chemical Biology
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    Aug 17, 2020
    A new paper from @CarolynBertozzi and colleagues developed an αHER2 antibody-neuraminidase conjugate that targets sialic acid removal on breast cancer cell surfaces and enhances tumor cell killing by the host immune system. nature.com/articles/s4158…
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    Nature Chemical Biology
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    Feb 18, 2021
    What if we could have bespoke proteases to cleave any chosen target sequence? @davidrliu and colleagues are getting closer to that dream: they've shown in @sciencemagazine how to evolve botulinum neurotoxin proteases with altered cleavage specificities. science.sciencemag.org/content/371/65…
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    Nature Chemical Biology
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    Mar 8, 2021
    Work from the Woo laboratory (@drcmwoo) developed split O-GlcNAcase proteins fused with nanobodies to target the selective removal of O-GlcNAc protein modifications. Free to read at rdcu.be/cgplp. nature.com/articles/s4158…
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    Nature Chemical Biology
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    Apr 1, 2021
    Using HaloTag and a suite of synthetic fluorophores, @claire_deo, @Abdelfattah_A, @rhodamine110, @ERSchreiter and colleagues developed a general platform for making far-red chemigenetic sensors. Free to read: rdcu.be/chUw9. nature.com/articles/s4158…
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    Nature Chemical Biology
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    Oct 21, 2021
    New work from @alessiociulli @danetteldaniels and coworkers reports trivalent PROTACs targeting two domains in the same protein that enhance protein degradation via increased avidity and cooperativity. Free to read: rdcu.be/czW1S nature.com/articles/s4158…
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    Nature Chemical Biology
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    Dec 5, 2022
    A new paper from @erblabs, @Chrizzly_92, @eventuallyptrck enabled a 54-step in vitro biosynthesis of the macrolide backbone of the antibiotic erythromycin from CO2. Open access:
    Content cover image
    Synthetic anaplerotic modules for the direct synthesis of complex molecules from CO2
    From nature.com
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    Nature Chemical Biology
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    May 19, 2022
    A new paper from Jack Taunton and colleagues developed salicylaldehyde-based chemical probes that reversibly and covalently modify the catalytic lysine of protein kinases, with sustained occupancy in cells and animals. Free to read: rdcu.be/cNVx8 nature.com/articles/s4158…