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David R. Liu
@davidrliu
Professor at Harvard and the Broad Institute. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1
Massachusetts, USA
evolve.harvard.edu
Joined November 2008
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    David R. Liu
    @davidrliu
    May 21
    Today in @NatureBiotech we report a new suit of PE8 prime editor proteins. PE8 variants were developed from laboratory-evolved PE6 proteins using AI-guided protein redesign. This approach combines recent advances in computational protein design and directed evolution to increase
    82K
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    David R. Liu
    @davidrliu
    Mar 27, 2020
    Study of 206 monoclonal antibodies against #SARSCoV2 isolated from 8 #COVID19 patients. Some antibody clones are highly effective at neutralizing live SARS-CoV-2 virus in cells, suggesting that we now know human antibody sequences that would be effective COVID-19 drugs. (1/2)
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    David R. Liu
    @davidrliu
    Sep 11, 2022
    Graduate school.
    Tansu Yegen
    00:00
    Tansu Yegen
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    David R. Liu
    @davidrliu
    Dec 11, 2022
    Alyssa, a 13-year old T-cell leukemia (ALL) patient in the UK, was the first person to receive a base editing therapeutic—T cells with three base edits—and the first patient reported to benefit from base editing: complete remission, 6 months later. 1/3
    Alyssa
    Base editing: Revolutionary therapy clears girl's incurable cancer
    From bbc.com
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    David R. Liu
    @davidrliu
    Jan 11, 2022
    Today we report in @CellCellPress an engineered virus-like particle (eVLP) platform that mediates efficient in vivo delivery of therapeutic proteins, including base editors and Cas9 nuclease, resulting in therapeutic editing in multiple mouse organs. 1/14 drive.google.com/file/d/1GdJLA4…
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    David R. Liu
    @davidrliu
    Oct 21, 2019
    Today we describe prime editing, a very versatile new approach to genome editing in human cells without cutting the DNA double helix. We integrated a reverse transcriptase with a disabled CRISPR enzyme to copy virtually any edit from an engineered guide RNA into a target site...
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    David R. Liu
    @davidrliu
    Jun 2, 2021
    Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that causes sickle cell disease (SCD), the most common deadly genetic disorder, rescuing the disease in mice. drive.google.com/file/d/14nV5UQ… nature.com/articles/s4158… 1/11
    drive.google.com
    Newby_SCD_main.pdf
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    David R. Liu
    @davidrliu
    Mar 30, 2023
    Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. science.org/doi/10.1126/sc… PDF: drive.google.com/file/d/1H1k8AA… 1/17
    657K
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    David R. Liu
    @davidrliu
    Oct 6, 2024
    Sammy Basso @SammyBasso, one of the most remarkable people to share our world, passed away last night from complications associated with progeria, the ultra-rare ‘rapid aging’ genetic disease Sammy both suffered from and transcended. Sammy realized that a base editing treatment
    19:01
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    David R. Liu
    @davidrliu
    Jul 17, 2023
    Replying to @davidrliu
    Here’s the video for direct viewing in Twitter. Thank you @yaireinhorn for uploading.
    191K
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    David R. Liu
    @davidrliu
    Jan 6, 2021
    Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4W0z…
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    David R. Liu
    @davidrliu
    Jul 4, 2023
    Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed
    312K
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    David R. Liu
    @davidrliu
    Nov 29, 2022
    Science educators searching for a compelling way to teach the importance of understanding how small molecules, macromolecules, and macromolecular assemblies differ: your quest is at an end.
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    David R. Liu
    @davidrliu
    May 15, 2025
    In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,
    248K
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    David R. Liu
    @davidrliu
    Mar 7, 2025
    Truth and wisdom at Boston #StandUpForScience
    87K