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The impact of age-related diseases happen sooner than you think. Welcome to the Thalion Initiative...
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The Thalion Initiative (US)
119 posts
The Thalion Initiative (US)
@TTIScience
The Thalion Initiative is a global researcher driven initiative focused on the fundamental biology of aging.
US Head Office. Visit @TheThalionInit in Canada
- The Thalion Initiative (US) reposted
Gero has been named a 2026 Technology Pioneer by the World Economic Forum (WEF) for Advancing the Physics of Aging in Drug Discovery Gero’s physics-first AI drug discovery platform is transforming breakthroughs in the physics of aging into a pipeline of medicines designed to
- The Thalion Initiative (US) reposted
The biology is ready? ...to be studied, sure. That's why we need funding. Nice proof-of-concept grant opportunity for repro agingThe biology is ready. The researchers are ready. The funding hasn't kept up...until now. @ResearchHub is offering $10k for research on reproductive longevity. 🧵
- The Thalion Initiative (US) repostedAre biophysical constraints biology's underrated variable? We focus mostly on signalling molecules but this new paper from @PetrovaLab shows that a physical constraint like osmotic pressure can block lymphatic vessel growth even when growth factors are abundant. So it's not
- The Thalion Initiative (US) repostedGreat piece on comparative biology and what it can teach us about aging by @Aria_Babu . Humans are already outliers. Most mammals get 1 billion heartbeats, we get 2 billion; we live decades past reproduction and way longer than animals our size. Yet there's so much more to learn
- The Thalion Initiative (US) repostedDid they just discover cellular bombs? Biology is so much fun
- A great snapshot of the field, and good to see the recognition of comparative and evolutionary biology in this report - we're betting a lot on it @TTIScience.
- The Thalion Initiative (US) reposted
In this latest Lifespan Interview @DToddWhite discusses @TTIScience: applying a first-principles approach to aging biology, and building tools and datasets needed to accelerate longevity research. 👉 Read more: - The Thalion Initiative (US) repostedEveryone being excited that Bryan Johnson might “fix women’s health” in itself shows how dire the situation is. It's been so underfunded and under-researched that a wealthy man publicly funding a high-touch diagnostic workup for his girlfriend can look to some as one of the mostWhat do you mean Bryan Johnson is doing his weird science shit on his girlfriend but its probably the most comprehensive and highly funded research in women's health and he is probably going to cure endometriosis ?????
- The Thalion Initiative (US) repostedCats aren’t worms. You don’t casually double the lifespan of a mammal. What we have is evidence of a large 1-year survival benefit in a tiny group of cats already suffering from advanced kidney disease. The 30-year claim is based on nothing. It's still exciting but for aScientists in Japan have developed a groundbreaking treatment that could double the average lifespan of cats, extending it from around 15 years to nearly 30 years. The key lies in a protein called AIM (Apoptosis Inhibitor of Macrophage), discovered by Dr. Toru Miyazaki. While
- The Thalion Initiative (US) repostedEggcelent work from Colossal 🥚 Artificial eggs for avian development are a genuinely eggciting step - not just for de-extinction, but for rethinking developmental environments. From incubation to ex utero systems and artificial wombs… a very fertile direction. I worked in anWe just built an artificial egg. It supports full bird development outside a natural shell, and could help hatch massive extinct birds like the South Island giant moa, whose eggs were too big for a living bird to hatch. We rebuilt the egg. Now we’re rebuilding what’s possible.
00:00 - The Thalion Initiative (US) repostedReally impressive work! MouseMapper feels like a glimpse into the future of biology: whole-body, cell-level perturbation mapping, powered by deep learning and paired with spatial proteomics. And of course we love a paper with pretty picturesToday in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733
00:00 - The Thalion Initiative (US) reposted
Aging follows a predictable pattern. That suggests it's not random damage—it's programmed. Dr. João Pedro de Magalhães @jpsenescence proposes an interesting perspective on the theoretical underpinning of aging: our DNA is the hardware, while the epigenome—the chemical tags that
