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Ali Max Erturk
@erturklab
CEO of @DeepPiction, director at Helmholtz, LMU Prof. AI-based technologies for health. Weโ€™re๐Ÿ‡ฉ๐Ÿ‡ช๐Ÿ‡น๐Ÿ‡ท๐Ÿ‡ญ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ณ๐Ÿ‡ฎ๐Ÿ‡น๐Ÿ‡ฎ๐Ÿ‡ณ๐Ÿ‡ธ๐Ÿ‡ฎ๐Ÿ‡ด๐Ÿ‡ฒ๐Ÿ‡จ๐Ÿ‡ฑ๐Ÿ‡ญ๐Ÿ‡บ๐Ÿ‡ง๐Ÿ‡ฌ๐Ÿ‡บ๐Ÿ‡ฆ๐Ÿ‡ท๐Ÿ‡ด๐Ÿ‡ฆ๐Ÿ‡น๐Ÿ‡น๐Ÿ‡ผ๐Ÿณโ€๐ŸŒˆ
Munich, Germany
Joined March 2018
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    Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it๐Ÿ”ฌ๐Ÿง ๐Ÿฆ ๐Ÿงต๐Ÿ‘‡@cellhostmicrobe cell.com/cell-host-micrโ€ฆ
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    I am excited to share preprint of our DeepMACT technology, based on vDISCO and deep learning. DeepMACT reveals cancer metastasis and antibody drug targeting at single cell level in whole mouse body in an unbiased and automated way. biorxiv.org/content/10.110โ€ฆ
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    We are very excited to introduce SHANEL to map adult human organs. It employs a new tissue permeabilization chemistry for labeling and clearing. We generated the first transparent adult human brain. Developed by amazing scientists @shan_heather et al. biorxiv.org/content/10.110โ€ฆ
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    ๐Ÿ˜ฎ~60% of us who had COVID still might have lingering viral spikes in our heads! Our new study reveals SARS-CoV-2 spike accumulation in the skull-meninges-brain axis & its implications in long COVID. By @zhouyi_rong @HongchengM @Sakethkapoor๐Ÿ”ฌ๐Ÿง ๐Ÿฆ ๐Ÿงต๐Ÿ‘‡ biorxiv.org/content/10.110โ€ฆ
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    Many work with microglia How many microglia are there in the brain? We found the answer with our most advance technology: biorxiv.org/content/early/โ€ฆ
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    Neuronal connectome of a whole adult mouse revealed by vDISCO technology biorxiv.org/cgi/content/shโ€ฆ
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    Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this๐Ÿค—, creating the first whole body vascular, lymphatic, and nerve atlases. By @HongchengM @jieluo692 biorxiv.org/content/10.110โ€ฆ ๐Ÿงต๐Ÿ‘‡๐Ÿผ(turn on the sound)
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    I am excited to share our publication of vDISCO technology: a whole mouse body clearing & imaging method nature.com/articles/s4159โ€ฆ. The thread below presents details of vDISCO and its biological findings. @NatureNeuro @Nature. Happy New Year all! 1/12
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    Discover the future of 3D-omics! Our perspective aritcle explores how tissue clearing and AI with single-cell omics could revolutionize understanding of entire organs & organisms. Read the full article: nature.com/articles/s4159โ€ฆ
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    What if we could map every cell in the body, revealing its location and molecular identity? In this @naturemethods perspective, we discuss the new era of 3D-omics by tissue clearing and AI, called Deep 3D Histology: rdcu.be/dNBe8 PDF: bit.ly/3WaD0QU ๐Ÿงต๐Ÿ‘‡๐Ÿผ
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    What if we could map every cell in the body, revealing its location and molecular identity? In this @naturemethods perspective, we discuss the new era of 3D-omics by tissue clearing and AI, called Deep 3D Histology: rdcu.be/dNBe8 PDF: bit.ly/3WaD0QU ๐Ÿงต๐Ÿ‘‡๐Ÿผ
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    Tissue clearing yields cool 3D images but not much molecular data. Not anymore๐Ÿค— Meet DISCO-MS enabling unbiased proteomics profiling of 3D-imaged organs. biorxiv.org/content/10.110โ€ฆ We co-developed with @labs_mann work by @HarsharanBhatia & @ADBxMPIB collab. with @fabian_theis๐Ÿงต๐Ÿ‘‡
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    Spatial-omics goes 3D๐Ÿค—! Out at Cell @CellCellPress ๐Ÿ‘‰๐Ÿผ We developed DISCO-MS with @labs_mann, a spatial proteomics technology for specimens fully imaged in 3D. DISCO-MS is aided by robotics and enables the study of diseases at their early stages. cell.com/cell/fulltext/โ€ฆ๐Ÿงต๐Ÿ‘‡
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    Our new study is now published at @NatureBiotech as open access. What is in it? Online Whole-Body Mouse Atlases, tertiary lymphatic structures (TLS) in the whole mouse along cancer, and more. Meet wildDISCO, thread ๐Ÿ‘‡๐Ÿผ nature.com/articles/s4158โ€ฆ
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    The skull is considered a physical barrier (helmet) for the brain. Our new findings show that the skull can be utilized to interact and monitor neuroinflammation in diverse brain diseases. #scRNAseq #proteomics #skull #AI #clearing #TSPOPET biorxiv.org/content/10.110โ€ฆ details๐Ÿงต๐Ÿ‘‡1/n
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