Pinned
Today out in @biorxivpreprint we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial genomics. This was work led by the intrepid duo of Hanna Liao and Sanjay Kottapalli, with @JShendure's lab.
Sanjay Srivatsan
2,684 posts
Sanjay Srivatsan
@SRsrivatsan
Assistant Professor at @fredhutch. Previously, @UWproteindesign, @uwgenome, and @NIAIDNews. Building sequencing tools to explore biology.
- Thrilled to announce the opening of the Srivatsan Lab (srivatsan-lab.com) at the @fredhutch. The lab will be building new sequencing technologies to understand how our cells and bodies form over the course of development.The newest @FredHutch Basic Sciences lab opens its doors! The @SRsrivatsan Lab is developing new sequencing technologies to interrogate structure-function relationships during vertebrate development. The lab is growing and hiring at all levels: srivatsan-lab.com
- I'm virtually defending my thesis next Wednesday from 3:30 to 4:30 PM PST 🥳🥳🥳 I'm going to be talking about two single cell technologies I've developed, one for chemical genomics and another for spatial transcriptomics. DM me if you're interested and I can forward a link.
- I've been working at the @seattleflustudy with @lea_starita for the past month and we've been trying to work out (along with others) how to circumvent RNA extraction. In this brief paper we put forth a very simple protocol -results are *preliminary* (1/n)
- Elated to have our paper (science.sciencemag.org/content/early/…) out this week @sciencemagazine, I can't thank @joselmcfaline, @vram142, @JShendure and @coletrapnell enough. I've learned so much over the course of this project -- beyond the science the people we work with is most important
- Check out our paper —>Our paper on sci-Space, a spatially resolved version of sci-RNA-seq, is out today! Led by @SRsrivatsan and @mregier13, Joint work with @JShendure and @kellystevenslab. (Art by @nigelsussman)
- Check out our latest, where we use scaled single cell sequencing as a phenotyping tool. One of the key conceptual advances is the ability to estimate variation in organismal phenotype by resolving cells to individual organisms with at least n=8 replicates per condition.Our preprint on deep phenotyping of genetic perturbations of zebrafish embryos with single-cell RNA sequencing is now online. Led by @LSaund11 and @SRsrivatsan, with David Kimelman, @CeciliaMoens, @RaibleLab and @JShendure biorxiv.org/content/10.110…
- Pour out a virtual 🍺 for projects that didn't pan out. I just cleared out 10 freezer boxes full of constructs and primers. I can still remember the excitement I felt when I cloned each gene or made each plasmid
- I'm so sad, shocked, and heartbroken that Debbie is no longer with us at @uwgenome. Her mentorship style had the effect of making you feel singularly unique. I know we're going to feel her absence at research reports and miss hearing the crazy stories she often regaled us with .Replying to @NHGRI_DirectorNHGRI greatly valued Debbie’s wise input. Here she is at a June 2018 town hall @UW, an early event in the Genomics2020 Strategic Planning Process that yielded the 2020 NHGRI Strategic Vision. The other photos are from the Finale Meeting for the 2011 NHGRI Strategic Vision!
- Replying to @SRsrivatsanFinally, none of this is possible without the incredible infrastructure and set up @seattleflustudy by @mjonasrieder, @HelenChuMD, @LockwoodDNA, @debnick60, @lea_starita, @JShendure and many others. They have been tireless and single-minded in getting ahead of this pandemic.
- It was a blast to see y'all!! I feel like this is very on-brand for a MSTP student
- I’m very thankful to get this work out there. Last March I had my doubts as to whether COVID testing could be this simple, so it was heartening to see many other groups converge on the same solutionTerrific backstory on SwabExpress and @UW's Husky Coronavirus Testing Program. @SRsrivatsan @bethkarenmartin @lea_starita @LockwoodDNA @HelenChuMD and many other @BrotmanBaty @seattleflustudy students and staff SwabExpress: tinyurl.com/fsc53dva
