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How big is the human genome? We barely fit 1/1000 of the human genome sequence typed out on a hallway wall near my office @genome_gov! Take a look at the video and see what I mean...
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Eric Green
4,368 posts
Eric Green
@NHGRI_Director
- Today’s #NobelPrize winner Svante Pääbo is a true authority on the study of ancient DNA. He was the first to successfully clone DNA from a mummy, and in 2009, he completed sequencing of the Neanderthal genome (in collaboration with Jim Mullikin @genome_gov!).
- This is a historic day, as we announce the publication reporting that the Telomere-to-Telomere (T2T) consortium has generated the first truly complete human genome sequence. genome.gov/T2T
00:00 - When the Human Genome Project began, there was not a widely functional internet. I was barely using e-mail! The first sequences generated from human chromosome 7 were handwritten and faxed to me so that I could develop markers for building a physical map of human chromosome 7.
- On October 1, 1990, the Human Genome Project officially started. Since then, genomics has grown and expanded beyond anything that I could have ever imagined.
- When the Human Genome Project started, the first sequences generated from human chromosome 7 were handwritten on paper and faxed to me so that I could develop markers for building a physical map of chromosome 7. Handwritten? Faxing? Talk about something that was soooo ‘90s….
- One of the most common misperceptions about genomics and genetics is that genes determine everything in biology. But it is actually not genes alone! Phenotypes, or traits, are a result of complex interactions between genes and other biological factors, like the environment.
- This photograph is of me at the midpoint of the Human Genome Project, as my research group was working feverishly to build a physical map of human chromosome 7. The stress of genomic advances had not yet turned my hair grey… that would come later.
- Researchers have had great success using genomics to identify the genetic causes of rare diseases. In 1990, scientists only knew the responsible gene for 61 rare diseases. Today, that number is over 5,600!
- Genetics and genomics are both important in health, but what is the difference between them? Genetics refers to the study of inheritance and the ways that traits or conditions are passed down from one generation to the next. Genomics describes the study of all of a person's DNA.
- My older brother, Michael R. Green, passed away suddenly and unexpectedly at the age of 69 late last week. This is a huge loss -- for his wife Maria, for @UMassChan, for me, for science.
- 70 years ago today, two scientists walked into a pub and announced they had just “found the secret of life,” referring to DNA’s double helix (thanks to Rosalind Franklin). But this anecdote doesn’t capture how this moment was a paradigm shift in molecular biology. (Thread)
- Genetics and genomics are both important in health, but what is the difference between them? Genetics refers to the study of inheritance and the ways that traits or conditions are passed down from one generation to another. Genomics describes the study of all of a person's DNA.
- Most genomics studies to date have studied people of European ancestry. Because of this lack of diversity, we lack sufficient data about genomic variants from non-European populations to confidently calculate polygenic risk scores for these groups.
