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The @BlavatnikAwards made a little video about our lab and the work we do:
youtube.com/watch?v=-o43Bf…
@uclcancer @CRUKCOLcentre @CRUKLungCentre
Nicholas McGranahan
387 posts
Nicholas McGranahan
@NickyMcGranahan
Group leader at the CRUK-UCL Lung Cancer Centre of Excellence. Cancer genomics, bioinformatics, and somatic evolution.
- CONIPHER, our method for automated reconstruction of tumour subclonal structure and phylogeny that we used in our recently published TRACERx studies, is now out in Nature Protocols! (nature.com/articles/s4159…). Welcome to the CONIPHER TREEtorial, just in time for Christmas! 🌲 1/n
- Latest #TRACERx paper out in @nature - exploring how the immune system sculpts lung cancer evolution: go.nature.com/2CuGPZk . Big team effort @CharlesSwanton @StephanBeck6 @AndyFeber @SwantonLab @squezadd @MariamJHanjani @nbirkbak Blog here: bit.ly/2CujVRA
- Our paper together with @SwantonLab @CharlesSwanton ‘Genomic-transcriptomic evolution in lung cancer and metastasis’ comes out today @Nature. nature.com/articles/s4158… Read all about it 🚨👇 1/9
- Very excited to share this review by @jrm_black We explore the importance of both genetic and non-genetic ITH and their role in tumour evolution, and argue for a broad research focus beyond the cancer genome: nature.com/articles/s4156…
- Excited to share our latest work investigating why tumours frequently double their genomes and how we can exploit this to identify cancer genes. #TRACERx @Saioa_l @CharlesSwanton @uclcancer @TheCrickInterplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution (López et al.) go.nature.com/3aBqdhf
- Incredibly honoured that our work has been recognised! Our work is computational, focussing on using data to understand cancer - we are entirely reliant on wonderful collaborators and public data. (& generous funders @wellcometrust @CRUKCOLcentre @CRUKLungCentre @RosetreesT)🎉The Blavatnik Awards and @nyasciences are excited to announce the Honourees of the 2024 Blavatnik Awards in the UK! Please join us in congratulating these nine incredible scientists sparking innovations that will transform our future world. Learn more: blavatnikawards.org/news/items/pre…
- Excited to share out latest paper : nature.com/articles/s4158… Do you want to infer T cell infiltrate, but only have bulk DNA-seq? Our tool, T Cell ExTRECT, provides a solution! And here's tweetorial about our serendipitous discovery 👇Out now in @nature! Introducing our new method T cell ExTRECT that uses DNA sequencing data to directly quantify T cell fraction and its application in cancer. A quick thread 🧵 nature.com/articles/s4158… (1/20)
- Our new paper exploring allele specific HLA loss and immune evasion in lung cancer is out in Cell: goo.gl/eDEFzo @CharlesSwanton
- Extremely proud of @AMIHuebner - passing her viva with flying colours (never in doubt!)...and many thanks to her examiners @markowetzlab @NischalanP @uclcancer @CRUKCOLcentre @CRUKLungCentre #cancerevolution #cancermetastasis
- Exciting computational post-doc position available in our lab. Hate cancer? Love research? Enjoy harnessing computational tools to explore the interplay between cancer cell plasticity and cancer genome evolution? This job is made for you.
- Instead of watching match of the day tonight, why not read our latest work exploring how RNAseq can be harnessed to discover cancer drivers? Thread👇📢Our preprint ‘RNA allelic frequencies of somatic mutations encode substantial functional information in cancers’ is out today. Excited to tell you all about it, and our new tool, RVdriver: biorxiv.org/content/10.110… (1/8)
- Are there rules to cancer evolution and chromosomal instability? Very excited to have contributed to work with @tbkwatkins @LimEmilia @rfschwarz @CharlesSwanton @Samuel_Bakhoum published in @Nature Paper 👉nature.com/articles/s4158…👈 Thread👇1/24 - Can we decipher order from cancer genomes? Our new paper “Pervasive chromosomal instability and karyotype order in tumour evolution” comes out in Nature today: nature.com/articles/s4158… @BCRFcure @TheCrick @CRUKresearch @RosetreesT @uclcancer @SwantonLab @royalsociety
