Howard Chang (@HowardYChang) / X

Howard Chang

173 posts

Howard Chang

@HowardYChang

Joined October 2015

Howard Chang
@HowardYChang
Nov 21, 2024
I am excited to join storied biotech pioneer @Amgen as Chief Scientific Officer and Head of Research. I look forward to partnering with my new colleagues to deepen understanding of biology and develop solutions to the most pressing medical challenges
AMGEN ANNOUNCES SENIOR EXECUTIVE RESEARCH APPOINTMENT| Amgen
From amgen.com
48K
Howard Chang
@HowardYChang
Apr 24, 2020
Very honored to join the fellowship of my scientific and cultural heroes! All credit to my students and mentors.
Benoit Bruneau
@benoitbruneau
Apr 23, 2020
Congrats @HowardYChang!
Howard Chang
@HowardYChang
Jan 10, 2024
Delighted to be honored by the King Faisal Prize. I am deeply grateful for all my mentors, collaborators, supporters, and especially lab members former and present. tinyurl.com/yssd6u8b
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Howard Chang
@HowardYChang
Aug 27, 2021
Delighted to share our new paper @MolecularCell, discovering circular RNA translation start elements. Congrats to first author Chun-Kan Chen, with @WeingartenShira, @segal_eran, @SnyderShot , @JswLab,@PeterKJackson, and more. tinyurl.com/4hfaveyw
Howard Chang
@HowardYChang
Jun 11, 2020
X chromosome silencing by viral mimicry! Xist lncRNA pretends to be a virus to get the female cell to shut down the second X chromosome. Great work by Ava Carter, Jin Xu @stanfordmed and with Wuttke lab @CUBIOCHEM1.
HHMI
@hhmi_science
Jun 9, 2020
The latest research from HHMI Investigator @HowardYChang and colleagues is an important step towards understanding how female cells carry out dosage compensation in mammals. bit.ly/2Yi4nL9
Howard Chang
@HowardYChang
Apr 18, 2019
Delighted to share this work with @WJGreenleaf and @10xGenomics Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
biorxiv.org
Massively parallel single-cell chromatin landscapes of human immune cell development and intratum...
Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here we present a massively parallel droplet-based platform for mapping transposase-ac...
Howard Chang
@HowardYChang
Jul 30, 2019
Clonal replacement of cancer fighting T cells by checkpoint blockade. Delighted to share our latest paper. Great team work with Katie Yost, @Satpathology, Dr. Anne Chang, and @parkerici!
Nature Medicine
@NatureMedicine
Jul 29, 2019
After anti-PD-1 therapy in basal or squamous cell carcinoma patients, the CD8+ T cell response largely consists of an expanded and exhausted repertoire of new #Tcell clones | go.nature.com/2Onv7bi #ImmunoTherapy @HowardYChang
Howard Chang
@HowardYChang
Nov 10, 2020
Excited to share our preprint on BABEL, a computational method to translate and synthesize multiomic profiles in single cells. biorxiv.org/content/10.110…. Wonderful work by grad student Kevin Wu and with @james_y_zou.
biorxiv.org
BABEL enables cross-modality translation between multi-omic profiles at single-cell resolution
Simultaneous profiling of multi-omic modalities within a single cell is a grand challenge for single-cell biology. While there have been impressive technical innovations demonstrating feasibility –...
Howard Chang
@HowardYChang
Jan 17, 2018
Celebrating this special honor with all of my mentors, lab members, and supporters who made it possible.@HowardYChang of @StanfordMed earns 2018 @theNASciences Award in Molecular Biology for work on long noncoding RNAs! #MolecularBiology #epigenetics nasonline.org/programs/award…
Howard Chang
@HowardYChang
Apr 12, 2019
Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA doi.org/10.7554/eLife.…. Delighted that our work with the Majeti lab is published!
elifesciences.org
Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondr...
Epigenome and Mitochondrial Barcode of Lineage from Endogenous Mutations (EMBLEM) enable tracking cell lineage in combination with chromatin profile in ATAC-seq data.
Howard Chang
@HowardYChang
Aug 27, 2017
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues biorxiv.org/content/early/…
Howard Chang
@HowardYChang
Aug 29, 2018
Our new study with the Zhang lab! Dynamic Regulation of RNA Structure in Mammalian Cells biorxiv.org/content/early/…
Howard Chang
@HowardYChang
Nov 20, 2019
Cancer genes beyond chromosomes--delighted to contribute to this new study. Great teamwork with Paul Mischel, Roel Verhaak, Vineet Bafna, and Bing Ren.
Howard Chang
@HowardYChang
Dec 13, 2018
Fascinating!! An RNA-binding region regulates CTCF clustering and chromatin looping biorxiv.org/content/early/…