Viruses & Proteases, Head of Infection Biology Unit, Deutsches Primatenzentrum @DPZ_eu, Decoding viral entry, Tracking SARS-CoV-2 variants, Views are my own
The "undead" BA.3.2 variant lives on - new sequence from South Africa, EPI_ISL_20075682: 11-year-old girl, sample taken June 12, 2025, under pneumonia surveillance.
#COVID19#VariantWatch#BA32
⚠️Mutated H3N2 influenza heads to northern hemisphere, prepare for worst seasonal flu epidemic in decades.
✴️7 mutations appeared in a strain of H3N2 seasonal flu in June 2025. These partially evade prior immunity, and are not fully covered by the current flu jab.
✴️Linked to
Continued surveillance and variant analysis is important, as highlighted by the emergence and spread of BA.3.2. Lack of data sharing by GISAID is bad news.
On Oct 1, 2025, @GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
Yesterday I was wondering why no new BA.3.2 sequences were showing up. Well, here’s a fresh one: EPI_ISL_20094964 from Western Australia. The variant is making its rounds globally — just as we feared.
#BA32#SARSCoV2#VariantTracking
BA.3.2 still showing strong activity in Australia - 5 new BA.3.2 sequences added to GISAID today, the newest collected October 3. One sequence labeled BA.3 appears to be BA.3.2.
#BA32#GISAID#VariantTracking
BA.3.2 has arrived in the UK. One BA.3.2.2, collected October 5, was uploaded from Scotland today.
Same branch as recent BA.3.2.2 from Germany & Slovenia.
It has a few errors (ins214:ASDT misread & ORF1a:E4388K artifact). Ignoring those, the 1 notable new mutation is N:N126K.
4% of new sequences reported from Germany today are BA.3.2.2 (n = 4), while 40% of the sequences from Western Australia belong to the same sublineage.
An unexpected comeback in Germany - and BA.3.2.2 might be on the road to dominance in Western Australia (WA).
And a new BA.3.2.2 sequence from Slovenia (EPI_ISL_20236520, collected on November 2) - a first for the country.
The Great Pumpkin remains active in different parts of the world...🎃