user avatar
Matt Kaeberlein
@mkaeberlein
Husband, father, scientist, athlete (sort of), CEO, recovering academic. Passionate about helping people and companion animals live longer, healthier lives.
optispan.life
Joined September 2013
340
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31.3K
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  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Mar 3, 2024
    After careful consideration, I have renounced my membership in the Academy for Health and Lifespan Research (@ahlresearch). I find it deeply distressing that we’ve gotten to a point where dishonesty in science is normalized to an extent that nobody is shocked when a tenured
    306K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Dec 21, 2023
    Help save the Dog Aging Project. Despite being one of the most influential, productive and impactful NIH supported projects over the past 5 years, the National Institute on Aging has inexplicably chosen to withdraw support for the Dog Aging Project. For now, I’m won't get into
    207K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Apr 3, 2022
    Ok folks, pay attention. Percent lifespan extension means nothing when the controls are short-lived. The next time someone Tweets about how “X increases lifespan in mice by Y percent!!!”, first thing you should do is look at the absolute lifespan of the controls /1
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Jan 13, 2023
    For those interested in a reasonably balanced and mostly hype-free breakdown of the recent reprogramming studies, I'd recommend this article. Two research teams reverse signs of aging in mice
    Two research teams reverse signs of aging in mice
    From science.org
    67K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Mar 11, 2024
    Just listened to @bradstanfield’s video, and while some of the details are off, the general theme is accurate. Given that I already know this story, I was still struck when @davidasinclair lies publicly about his research (starting at ~8:10) on @PeterAttiaMD's podcast. Frankly,
    user avatar
    Dr Brad Stanfield
    @BradStanfieldMD
    Mar 10, 2024
    The David Sinclair (@davidasinclair) $720,000,000 Resveratrol Train Wreck Video shoutouts: - Prof. Matt Kaeberlein (@mkaeberlein) - Prof. Brian Kennedy (@BKennedy_aging) - Dr. Peter Attia (@PeterAttiaMD) - Prof. Richard Miller - Prof. Jeffery Flier (@jflier)
    00:00
    138K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Feb 2, 2023
    My results from three of the most popular "biological age" tests taken from blood samples in late Dec 2022: 36 years, 39 years, and 59 years. Chronological age: 52 years this month. What does this tell us about the current state of consumer "biological age" testing?
    93K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Jan 20, 2023
    In 2020, chronic (age-related) disease afflicted 50% of the population, and consumed >85% of health care costs in the US. That number is growing. When does the system break down completely? 90%? 95%? We need to start treating the root cause of these diseases, before that happens
    36K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    May 29, 2022
    A prediction: The first senomorphic/senolytic to be widely used for that purpose (rapamycin?) will be >10-fold more effective for healthy lifespan than the top 5 cancer therapies combined. Achieved with geroscience research receiving less than 1% the funding of cancer research
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Feb 20, 2022
    Don't be fooled into thinking just because lots of papers are published on a topic, it must be "right". You have to look at the data. Most published research is done under the lamppost, studying what's popular, easy, or fundable. # of Pubmed hits does not equal truth
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Mar 20, 2024
    All the influencers are losing it over the new report that intermittent fasting is associated with a 91% increase in heart disease death. Obviously many caveats, and not published yet so don't know what other flaws exist, but this seems like a pretty big effect and probably worth
    80K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Jun 14, 2018
    One thing I like about bioRxiv. You get to see your work picked up by the scientific and popular press at the same time editors at "high impact" journals are telling you it isn't of sufficient general interest.
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Apr 4, 2025
    These two slides have become part of my go-to toolkit. They deliver a message of optimism, realism, and pragmatism. In the past 20 years, we’ve made remarkable strides in understanding biological aging. For all their limitations, the Hallmarks of Aging still represent a major
    20K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Feb 9, 2024
    To those claiming they have "reversed aging", here is why I push back on that. In my opinion - especially in science - extraordinary claims require extraordinary evidence. Claiming to make an animal age backwards is extraordinary! If anyone can show that they have made an old
    50K
  • user avatar
    Matt Kaeberlein
    @mkaeberlein
    Dec 22, 2022
    Particularly relevant for folks above age 40 who want to lose weight and increasingly so as you get older. Not only does lean tissue promote metabolic health, it's critical for preserving functionality. Resistance training should be a core part of every healthy longevity journey
    user avatar
    JT | Jerry Teixeira
    @jerryteixeira
    Dec 22, 2022
    Dieting while not resistance training is not a good idea for most Without RT, 20-30 % of the weight lost will be lean tissue, not fat Lean mass is one of your best tools you have to preserve metabolic rate while dieting Resistance train 2x per week if at all possible
    149K