What gene therapy would be on the top of your wishlist?
One biotech friend's answer: short sleep. It's ONE base pair flip and changes you into the type to only need 4 hours of sleep per night (!!!)
Isn't that basically a 17% "life" extension? @bryan_johnson
Jason Benn
1,811 posts
ML engineer, community builder, previously founded the Neighborhood SF, learning to meditate.
Anon feedback ๐ bit.ly/jbennfeedback
- LLMs are much more capable than anyone initially appreciated. GPT-3, by default, is playing some kind of weird improv game I'd call "Plausible Bullshitting". But engaging with it in clever ways reveals a more sophisticated model of the world.
- Some notes on being a great thinking partner (inspired by experiences with some of my friends):
- I've now read several posts now about people taking a serious medical problem into their own hands and solving it. They're pure competence porn, they increase my agency and hope just by reading them. First one, from @acesounderglass:My resentful story of becoming a medicalย miracle acesounderglass.com/2022/10/13/my-โฆ
- Time for a status update on the Neighborhood! The bottom line is that 100+ people have moved into 30+ new homes since February, twice our original 2022 goal of 50. Honestly, we've lost count.
- Replying to @jasoncbenn and @bryan_johnsonShe said it would take an expert 2 weeks to manufacture a bootleg gene therapy in a BSL 2 trailer (that admittedly costs $10Ms) at a safe purity level
- Replying to @tommycollisonMy friend has a habit of taking selfies with people she connects with at parties and then sending it to them. Now they'll remember her face, where they met, and that they were having a good time. Perfect 1st message
- What is culture? Culture is the ambient force that induces different ways of being into people. Similar to Alan Kay's "Perspective is worth 80 IQ points", I believe a powerfully good culture is worth, conservatively, 30 IQ points.
- I think Season 1 of the Neighborhood is complete. We figured out how to create a great community out of thin air, and then iterated on the recipe 4x. Now, the bottleneck is real estate. Once it makes financial sense to acquire and develop great houses, we can start Season 2.
- Replying to @arram and @bryan_johnsonThe FDAย only approves work on diseases, not general life improvements. So you'd do trials on people with sleep disorders, then expand/use off-label. The tech already works. It'd require a trailer-sized BSL 2 lab (that costs $10Ms) and 2 weeks from an expert to manufacture some.
- The Jhourney retreat was so much better than I expected - I got to jhana 1/2 on day 1 and 3/4 by the end of the week ๐ฎ I loved the experimental and self-guided format and they really cared about every one of us. 10/10. (nobody asked me to write this)
- I met a researcher whose open-source AI argument completely fell over within 1 sentence. She was like "open-source is safer, because more eyes means we'll find out when it's unsafe." My response was "What happens when you identify that it's unsafe?" She was stumped



