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Super excited to share that I will join @Princeton @omenndarlingbio this Fall as an assistant professor. We combine syn bio and AI to program macromolecules and cells for therapeutics engineering and drug target discovery.
Kaiyi Jiang
200 posts
Kaiyi Jiang
@idmjky
Assistant Professor @Princeton Previously Inaugural @Amgen Science Fellow with @HowardYChang, PhD at @MIT in AbuGoot lab and undergraduate @Rice
Joined March 2014
- Thrilled to share that EVOLVEpro is now published @ScienceMagazine Since our preprint, we now demonstrate low-N eningeering of both antibody and enzymes. We hope this model will broadly useful to the protein engineering field.
- Excited to share that our latest RADARS story is finally out in Nature Biotech. Since the last arXiv, we extensively engineered our sensor and now present RADARSv2 with better safety profile and enhanced sensitivity to detect genes as low as 13 TPM.
- Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synthetic phosphorylation circuits and its application in engineering cell therapy.
- Thrilled to share the final version of our fanzor paper. Since our arXiv, we added a comprehensive analysis of Fanzor1 and Fanzor2's in vitro activity, intron and MGE organization, NLS acquisition, and mammalian genome editing activity.
- Our new RNA-guided protease is out at Science today. With @CianSU @jgooten @omarabudayyeh @hnisimasu we applied it for mammalian RNA sensing.
- Looking forward to presenting RADARS at Single Cell Genomics DayInterested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day next Friday (3/4). All talks will be live-streamed (no registration required) at satijalab.org/scgd22
- Are RNA-guided nucleases outside prokaryotes? In this arXiv, we present a novel group of proteins named HERMES (Horizontally-transferred Eukaryotic RNA-guided Mobile Element Systems) and demonstrate their evolutionary trajectory from prokaryotic ancestor
- Excited to present RADARS, a new way to reprogram the cells with @omarabudayyeh @jgooten @insitubiology @lukas_villiger @91_naynayGenome editing owes a huge debt to genome sequencing With efforts like @humancellatlas, we’re sequencing cells like mad. What is the "Cas9" of single cell? With @omarabudayyeh @insitubiology: RADARS, for programmable cell-specific sensing/expression biorxiv.org/content/10.110… 🧵👇
- Check out our latest update on programmable genome insertion of large cargo (PASTE) now online @NatureBiotechDrag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases bit.ly/3GEisKB
- Thrilled to share my undergraduate work during my time @BashorLab. In this preprint we present comprehensive design rules for building protein circuits and engineering phosphorylation pathways in mammalian cells! check out the paper and this X-tutorial.
- Multifunctional Magnetic Nanoclusters Can Induce Immunogenic Cell Death and Suppress Tumor Recurrence and Metastasis
- Replying to @idmjkyThanks to an amazing team that made this happen. @jgooten @omarabudayyeh @alisankayabolen @MichaelTrinh18 @ssgriz @eugene_koonin #CRISPR @MITdeptofBE @mcgovernmit
- Replying to @jgooten @Princeton and @omenndarlingbioThanks Jonathan! It’s truly been the best PhD experience I could have hoped for!
