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Gary Ruvkun
@gary_ruvkun
Lab at Harvard/MGH, miRNAs and siRNA pathways of antiviral defense. Antibacterial defense and bacterial countermeasures, aging. Life on other planets.
Boston, MA
Joined May 2016
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    Recruiting for small RNA projects, electron transport chain and iron-sulfur cluster genetics (w Mootha lab), aging, bacterial/animal interaction, computational biology projects. Lab has launched many careers, listed on Ruvkun website.
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    Jobs for PhDs and techs. Ruvkun lab at Harvard/MGH. C. elegans small RNA, lifespan, bacterial defense pathways, analyzed with genetic screens and genome seq. Experience in genetics, any system, valuable. ruvkun.hms.harvard.edu CV+ letters rec to [email protected]
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    Projects powered by large-scale screening for dozens of mutants followed by full genome sequencing to reveal entire pathways. This genetics pivots projects into unexpected mechanisms. Hypothesis generating. Two to three author papers, not hundred author Big Science papers.
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    Ellsworth Dougherty one of the original nematode biologists. In a 3 window history exhibit in Kaiser hospital entry. He worked at Kaiser research richmond Visiting my sister. Excellent omen to see him celebrated. Few will recognize that name. Deep nematode history. Google him
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    After the online vaccination booking shitshow in Massachusetts last week the actual large scale vaccination site in Worcester was super effective and well organized. MA government out of my doghouse. And abrazos to Moderna Pfizer and all vaccine designers and production crews
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    Replying to @SenguptaLab
    I use the term Cardinal Systems. E coli, yeast, flies, worm genetics are akin to lighthouses for navigation of the seas. Intellectual maps of universal genetic pathways and specializations of particular clades. Codification of knowledge. But not model train sets. Locomotives
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    Replying to @andy_utoronto
    My view:C. elegans RNAi is more on target than the single siRNA or a couple siRNA mammalian RNAi. In worm, a 1 kb dsRNA produces 1000 siRNAs in parallel so that the on target effects of 1000 siRNAs sum, off target average. Worse in mammals perhaps.
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    Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. biorxiv.org/content/early/…. I am new to this
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    New to twit but char limit familiar; Morse code as a 14 year old ham radio nerd. Reincarnated 19th century telegraphers are finally at peace
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    Happy about the many responses to my photo comments on Ellsworth Dougherty. See ncbi.nlm.nih.gov/pmc/articles/P…. College grad at 18. Antarctic research. Kaiser Hospital Oakland. Worms!! Amazing science connoisseurship. But a terrible end.
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    Replying to @betenoire1
    Handle, 1920s roots in ham radio. CB evolved for folks w no interest in vacuum tube electronics. ham radio began w Morse code and its 19th century telegrapher jargon. A telegraph key=handle? The cadence of your Morse code could identify you. I was WB6VLB as a teen. 88.
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    Replying to @lucksmith
    SF Embarcadero. Jetlagged Visitors from EDT see it before dawn, etching it into memory. From wikipedia "loathsome monstrosity", a "howling obscenity", "pestiferous eyesore". technological excrescences deposited by a giant concrete dog with square intestines
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    And positive sign on the Dougherty omens accurate. My sister 1000% improved. Kaiser Oakland. Awesome. Cured me of dozens of childhood health burps between 1952 and 1973. A grateful shout out to my pediatrician Paul Rousseau. Another amazing life. discoveryislands.ca/news/back-issu…
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    Proteasome dysfunction triggers activation....ok to tweet work from your own lab? Nic Lehrbach was courgeous to post our first biorxiv.