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Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/)
eric hoyeon song
2,074 posts
- The first @VirusesImmunity lab brain tumor paper is out today! nature.com/articles/s4158…. We began the project wanting to understand the role of meningeal lymphatics in brain tumor. To our surprise, when we expanded the lymphatics with VEGF-C, mice could no longer grow tumors!
- @VirusesImmunity latest neuro story is up on biorxiv! biorxiv.org/content/10.110… We used brain organoids, K18-hACE2 mice and our recently described AAV-hACE2 mice to show the neuroinvasive potential of SARS-CoV-2. A huge collaborative effort, so we have a lot to share. Here we go...
- thelancet.com/journals/laneu… 40 post mortem brains. 50% with SARS-CoV-2 RNA or Protein 20% with both RNA and Protein. This combined with the clinical report yesterday emphasizes neurocovid to be something we should really watch for.
- 🚨looking for postdocs!!! 🚨 join us at our new, @YaleMed Neuroimmunology group! We are looking for postdocs to examine all things involving brain and ocular immunology. PLEASE TAG anyone you think would be a great addition to our team!#neuroimmunology #braintumor #ophthalmology
- Part 2 of SARS-CoV-2 and its effects on the Brain with @ShelFarFar and @VirusesImmunity! biorxiv.org/content/10.110… **Highlights** -Characterization of COVID-19 neuroinflammation -Indirect evidence of SARS-CoV-2 neuroinvasion -Evidence of local CNS immunity #COVID19 #brain 1/n
- Thank you @WeintraubAward for recognizing our work to be a part of an amazing cohort of works from international scientists! fredhutch.org/en/news/releas… And thank you to @VirusesImmunity and the @YaleIBIO department for the nomination for this award! medicine.yale.edu/news-article/3…
- :) doc topol shared!How #LongCovid brain fog resembles cancer "chemo-brain." An experimental model of mild Covid infection demonstrates microglial activation, loss of oligodendrocytes, confirmed at post-mortem in 9 people biorxiv.org/content/10.110… @VirusesImmunity @michelle_monje
- Our newest paper on how intranasal vaccination helps create local IgA production for protection against respiratory viruses like influenza. @JieunOh9’s awesome project that she let me be a part of :). And @VirusesImmunity’s impeccable summary of why this is so relevant!Our new study by @JieunOh9 @ericsongg @MiyuMoriyama et al shows that immune priming via intranasal route provides superior protection against heterologous respiratory virus challenge. The key is in inducing local secretory IgA with broader coverage. (1/) science.org/doi/10.1126/sc…
- Replying to @VirusesImmunityGreat to see these videos on Twitter for the world to see instead of back in the supplements! Thanks for highlighting these Akiko!
- Replying to @ericsonggIt seemed that the SARS-CoV-2 infected neurons didn't go through death pathways, but rather was using up more resources to produce high amounts of virus, creating a hypoxic environment for its neighboring cells. We confirmed this with some HIF1a staining
- Our work on how molecular mechanism of MMR deficiency affects immunotherapy outcomes is out on @CD_AACR! Check out the thread by the amazing @ScienceChow. Many thanks to Dr. Santin, @VirusesImmunity for letting us take the lead on this project and to the coauthors!Mismatch repair-deficient (MMRd) cancers all have ⬆️high mutation burdens, so why do some patients not respond to immune checkpoint blockade (ICB)? We explored this in a follow-up to a phase 2 trial of aPD-1 (pembro) in MMRd endometrial cancer @CD_AACR : aacrjournals.org/cancerdiscover…
