The final version of our study seeking to understand how even mild respiratory COVID can affect the brain is now published. Sharing an updated thread… 1/
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Michelle Monje 🟦
1,906 posts
Michelle Monje 🟦
@michelle_monje
Neuroscientist. Neuro-oncologist. Mom. @Stanford @HHMInews @CancerNeurosci. (Opinions are my own and do not reflect those of my employer)
- Bringing Qiagen RNA extraction kits from the research labs to the clinical lab for COVID19 testing. #teamwork
- #LongCOVID frequently includes cognitive symptoms. Noting the clinical similarities between “chemo-fog” and “COVID-fog”, we asked whether there are also neurobiological similarities, in collaboration with Akiko Iwasaki’s @VirusesImmunity lab @YaleMed. 🧵
- Glad to share this Perspective written with @VirusesImmunity, where we review what is understood about how COVID can affect the brain, discuss the possible neurobiological underpinnings & propose the main mechanisms that may contribute to COVID brain fog🧵
- It is the 15-year anniversary of our first (early post-mortem) #DIPG tissue donation… my lab has since received 106 such tumor donations💔. So today, we placed 106 roses, one in honor of each child, and planted 106 seeds, to represent the knowledge gained from each.
- Replying to @michelle_monjeCOVID survivors frequently suffer from lasting cognitive symptoms. Noting the clinical similarities between “chemo-fog” and “COVID-fog”, we asked whether there are also neurobiological similarities, in collaboration with Akiko Iwasaki’s @VirusesImmunity lab @YaleMed. 2/
- Enormously grateful that HHMI will be supporting our research in neural plasticity and CNS cancer, and to my lab members past, present and future! #DIPG #CancerNeuroscience #ChildhoodCancer HHMI Invests $300 Million in 33 New Investigators hhmi.org/news/hhmi-inve…
- The nervous system plays a central role in cancer pathogenesis and cancer & cancer therapies can alter nervous system form and function. To encourage multidisciplinary collaboration in this emerging field, we have created a program in Cancer Neuroscience at Stanford (CNS).
- So incredibly proud of @KarlDeisseroth, today and always, for his immense contributions to science. (It has been an exciting week in our household!)Decades of high-risk research, driven by his curiosity and passion, have earned neuroscientist & bioengineer, @KarlDeisseroth the Lasker Award, one of the most respected science prizes in the world. stan.md/3AGqkWa #Lasker2021 #Neuroscience #optogenetics @LaskerFDN
- Replying to @michelle_monjeThere are stark parallels between the cellular dysregulation that can happen after chemotherapy and even mild #COVID. Understanding the neurobiological underpinnings of #LongCOVID will lay the groundwork for therapeutic strategies to address this neurological health crisis. 15/
- Replying to @michelle_monjeWe found the same histological pattern of white matter-selective microglial reactivity in the brains of people with #COVID that we found after chemotherapy (tinyurl.com/Cell-2019), in collaboration with @nathavindra, #MyounghwaLee #RebeccaFolkerth #DanPerl #MarcoHefti 4/
- Replying to @michelle_monjeHow might even mild respiratory #COVID infection affect the brain? Using a mouse model of mild SARS-CoV-2 infection limited to the respiratory system, we found elevation of CNS cytokines/chemokines and white matter-specific microglial reactivity. 3/
- #CARTcells for #DIPG #DMG clinical trial (1st arm) results are out today. Full Tweetorial coming, but first want to share the story of a patient whose #DIPG has disappeared for over 3 years. It is a milestone and moment of hope on a journey filled with so much grief. “There’s a
- This is the first chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord.🧵(1/) nature.com/articles/s4158…
