Phil Leung (@definitelyphil) / X

Phil Leung

2,955 posts

Phil Leung

@definitelyphil

Co-founder @Xaira_Thera | @UWProteinDesign PhD instagram.com/definitelyphil

Seattle, WA

github.com/proleu

Joined July 2012

Pinned
Phil Leung
@definitelyphil
Oct 9, 2024
My doctoral advisor @UWMolES / @UWproteindesign (and current scientific advisory board membe @Xaira_Thera) David Baker won the nobel prize!! So stoked and extremely determined to deliver on the promise of this tech! nobelprize.org/prizes/chemist…
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Phil Leung
@definitelyphil
Dec 18, 2023
Today in @Nature we compare several compositions of AI-based and classical methods of peptide binder design to make binders to nine different physiologically relevant hormones and cell signaling peptides: nature.com/articles/s4158… Work led with @SusanaVazTor and @PreethamVi
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Phil Leung
@definitelyphil
Dec 11, 2024
What an immense privilege to celebrate the #NobelPrize with David, former colleagues from @UWproteindesign , current colleagues at @Xaira_Thera and @RosettaCommons family!
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Phil Leung
@definitelyphil
Aug 17, 2023
Online at @ScienceMagazine now: my paper with @FloPraetorius at @UWproteindesign We made tiny protein hinges that behave similarly to the hinges you encounter in the macroscopic world (gif credit @ichaydon , protein credit yours truly) science.org/doi/full/10.11…
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Phil Leung
@definitelyphil
Dec 30, 2022
While it's still 2022 I want to share some of the cool results in our @biorxivpreprint that we put up recently. (Work with @SusanaVazTor, Isaac Lutz, @PreethamVi, @_JosephWatson, @JosephRog ers100 and many other incredibly talented individuals) biorxiv.org/content/10.110… (1/11)
biorxiv.org
De novo design of high-affinity protein binders to bioactive helical peptides
Many peptide hormones form an alpha-helix upon binding their receptors[1][1]–[4][2], and sensitive detection methods for them could contribute to better clinical management. De novo protein design...
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Phil Leung
@definitelyphil
Jan 28, 2023
It's late but my @biorxivpreprint with @FloPraetorius is out and I'm too excited not to share it with you all #ProteinDesign:
biorxiv.org
Design of stimulus-responsive two-state hinge proteins
Proteins that switch between two structural states as a function of environmental stimuli are widespread in nature. These proteins structurally transduce biochemical information in a manner analogous...
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Phil Leung
@definitelyphil
Mar 19, 2024
Structure-based VHH design preprint is now up! @naterbennett0 @_JosephWatson @RobertRagotte @andrewjborst and special shoutout to @dejsee and Buwei who I collaborated with on this study. Watch this space closely, there's more coming :) @UWproteindesign
biorxiv.org
Atomically accurate de novo design of single-domain antibodies
Despite the central role that antibodies play in modern medicine, there is currently no way to rationally design novel antibodies to bind a specific epitope on a target. Instead, antibody discovery...
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Phil Leung
@definitelyphil
Mar 14, 2024
Super excited to finally see the publication of this great paper in @Nature; this was one of the first projects I got to work on in grad school! Home Depot inspired #ProteinDesign @UWproteindesign Work led by @tim_huddy @kribler Yang and @xu_jinwei nature.com/articles/s4158…
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Phil Leung
@definitelyphil
Mar 31, 2023
Moments before realizing I now have to deal with a lifetime of "Dr. Phil" jokes #phdlife #AcademicTwitter
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Phil Leung
@definitelyphil
Aug 14, 2024
Awesome paper in @Nature! @ArvindSPillai1 achieved theoretically perfect ligand binding cooperativity with a hill coefficient of ~4 (hemoglobin is ~2.8 by comparison). Congrats Arvind, Abbas, @FloPraetorius and team, truly an honor to help with this work:
De novo design of allosterically switchable protein assemblies
From nature.com
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Phil Leung
@definitelyphil
Sep 11, 2023
5 transformative yrs at @UWMolES @UWproteindesign @datamolecules @uwcse Much gratitude to everyone, especially advisors David Baker & @jeffnivala Next: launching a biotech startup with a top-notch team. Stay tuned.
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Phil Leung
@definitelyphil
Dec 11, 2022
Preprint is up! Grateful to have co-led this work with @SusanaVazTor , Isaac and @PreethamVi Thread soon but for now, rest 😂 #AcademicTwitter
biorxiv.org
De novo design of high-affinity protein binders to bioactive helical peptides
Many peptide hormones form an alpha-helix upon binding their receptors[1][1]–[4][2], and sensitive detection methods for them could contribute to better clinical management. De novo protein design...
Phil Leung
@definitelyphil
Apr 23, 2024
Excited to finally share what we've been working on since September (but really for over a year)! Great write-up by @AndrewE_Dunn and @RLCscienceboss on Xaira's goal of radically improving the entire drug development pipeline with an AI-first approach endpts.com/in-biggest-eve…
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Phil Leung
@definitelyphil
Mar 15, 2023
Excited to announce I will be giving a short talk "Multistate Design of Protein Hinge Switches" at #Keystone2023 Computational Design and Modeling of Biomolecules Hope to see some of you there!
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