Prashant Bhat (@_prashantbhat) / X

Prashant Bhat

267 posts

Prashant Bhat

@_prashantbhat

Physician/molecular biologist trying to improve human health MD '26 @UCLA👨🏽‍⚕️PhD '23 @Caltech Incoming Pathology Resident @UCSFPath

San Francisco, CA

Joined November 2017

Pinned
Prashant Bhat
@_prashantbhat
May 8, 2024
A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!
Mitch Guttman
@mitchguttman
May 8, 2024
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez
Genome organization around nuclear speckles drives mRNA splicing efficiency
From nature.com
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Prashant Bhat
@_prashantbhat
Oct 7, 2024
1st yr college (4/2011) Dr. Ambros visited Berkeley. His Cell 1993 paper was the 1st biology paper I ever read. After the talk, I asked for a picture; he looked around him when the organizer clarified, "Victor, he is asking to take a picture *with* YOU!" 🥲 Congrats, Victor!🧬
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Prashant Bhat
@_prashantbhat
Jan 6, 2023
In our new pre-print, we demonstrate that 3D genome organization around nuclear speckles controls the efficiency of mRNA splicing. Check out my thesis work @Caltech in this thread by @mitchguttman! @4DNucleome #Genomics
Mitch Guttman
@mitchguttman
Jan 6, 2023
What are the functional roles of 3D genome organization? In a new preprint led by @_prashantbhat, we demonstrate a critical role for dynamic 3D organization of genomic DNA around nuclear speckles in controlling the efficiency of mRNA splicing. biorxiv.org/content/10.110…
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Prashant Bhat
@_prashantbhat
May 6, 2023
🎓Defended my PhD thesis @Caltech this week! Grateful to my incredible advisor @mitchguttman, the @uclacaltechmstp, and the countless individuals who brightened my years in graduate school into a delightful experience of intellectual growth and discovery. Cheers to science! 🧬
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Prashant Bhat
@_prashantbhat
Nov 19, 2024
Hi! I’ll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link: forms.gle/LopwGCc8RbuCqS…
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Prashant Bhat
@_prashantbhat
Jun 2, 2024
It was fun to present at my first @RNASociety meeting in Edinburgh! Thanks to the organizers for a great meeting and the audience for the engaging questions! #RNA24 Want to chat about speckles and splicing in different cellular contexts, including disease processes? DM me!
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Prashant Bhat
@_prashantbhat
Aug 2, 2021
Our review is out in @NatRevMCB! Together with Drew Honson and @mitchguttman @Caltech we review how nuclear compartmentalization may explain many aspects of gene regulation within biomolecular condensates
Nature Reviews Molecular Cell Biology
@NatRevMCB
Aug 2, 2021
Now Online Nuclear compartmentalization as a mechanism of quantitative control of gene expression dlvr.it/S4tJBT
Prashant Bhat
@_prashantbhat
Jun 17, 2023
Officially Dr. Bhat! Next up: one year as a post-doc @Caltech before returning to medical school @dgsomucla!
3.2K
Prashant Bhat
@_prashantbhat
May 12, 2023
I am delighted to have been selected as one of the Everhart Distinguished Graduate Student Lecturers @Caltech! Thanks to the Graduate Studies Office and the @CaltechGSC for giving me the opportunity to present my thesis work to the Caltech community. Please join if you are local!
9.2K
Prashant Bhat
@_prashantbhat
Sep 23, 2021
Exciting and unexpected! We made the cover of @NatRevMCB! #BiomolecularCondensates #GeneRegulation
Nature Reviews Molecular Cell Biology
@NatRevMCB
Sep 23, 2021
From October cover Hot topic #Review by Prashant Bhat, Drew Honson & Mitchell Guttman @Caltech describing how nuclear compartmentalization controls gene expression #BiomolecularCondensates #GeneRegulation go.nature.com/3CBHgyj FREE pdf: rdcu.be/ctNBu
Prashant Bhat
@_prashantbhat
Jun 24, 2021
I am delighted to be awarded a Josephine de Kármán fellowship for my PhD research! I am incredibly thankful to my mentors and colleagues at @Caltech @uclacaltechmstp @dgsomucla and my adviser @mitchguttman for all of their support.
Caltech
@Caltech
Jun 24, 2021
Congratulations to Prashant Bhat, a graduate student in @uclacaltechmstp, on being awarded a 2021-22 fellowship from the Josephine de Kármán Fellowship Trust. Bhat studies the 3D organization of DNA and RNA in cells in the lab of @mitchguttman. caltech.edu/about/news/cal…
Prashant Bhat
@_prashantbhat
Nov 27, 2023
Woohoo! Grateful to @GenomeOrgAus for the honor of being named the Young TAD 2023! 🧬 I love that we have a fun and supportive network of genome organization aficionados!
Genome Organisation Australia
@GenomeOrgAus
Nov 27, 2023
🥁 🪘 🥁 The winner of the GOA Young TAD for 2023 is Prashant Bhat @_prashantbhat 🤩🏆 congratulations to all the contestants and thanks to the judges!
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Prashant Bhat
@_prashantbhat
May 28, 2023
Check out my last talk as a graduate student @Caltech online now! 2 parts: 1. Structure: Development of SPRITE to map RNA-DNA contacts throughout the nucleus. 2. Function: How 3D RNA-DNA contacts around nuclear speckles drives splicing efficiency. Link: tinyurl.com/4ptutfpu
Prashant Bhat
@_prashantbhat
May 12, 2023
I am delighted to have been selected as one of the Everhart Distinguished Graduate Student Lecturers @Caltech! Thanks to the Graduate Studies Office and the @CaltechGSC for giving me the opportunity to present my thesis work to the Caltech community. Please join if you are local!
5.6K
Prashant Bhat
@_prashantbhat
Oct 7, 2024
Replying to @_prashantbhat
And a big and hearty congratulations to Gary Ruvkun, too!
3.1K