David Sancho (@SanchoLab) / X

David Sancho

1,661 posts

David Sancho

@SanchoLab

Passionate about #immunology. Sensing damaged self, infections & microbiota by DCs and macrophages to ignite innate & adaptive immunity. #Immunometabolism

Professor @CNIC, Madrid, Spain

cnic.es/en/investigaci…

Joined September 2019

Pinned
David Sancho
@SanchoLab
May 25
Does #mitochondrial #respiration in DCs just “fuel” activation? In our new @SciImmunology study, we show that mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s science.org/doi/10.1126/sc… @CNIC_CARDIO
10K
David Sancho
@SanchoLab
Jul 16, 2025
💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s4158… #OpenAccess at @Nature @CNIC_CARDIO #microbiome #CVD
Imidazole propionate is a driver and therapeutic target in atherosclerosis
From nature.com
28K
David Sancho
@SanchoLab
Jul 23, 2023
Do you have and MSc and would like to do a PhD in Immunology? Are you interested in exploring mitochondrial metabolism in dendritic cells and macrophages? We offer a 4-year PhD position @CNIC_CARDIO 👇👇👇 Please, RT.
72K
David Sancho
@SanchoLab
Feb 4, 2023
Glad to share a FREE LINK to our @ImmunityCP by @SWculek et al. #OXPHOS #metabolism is differentially used and required for maintenance by #macrophages in tissues (TMFs), depending on the organ and the homeostatic or inflammatory state (1/12) authors.elsevier.com/a/1gXO13qNrUu3…
74K
David Sancho
@SanchoLab
Dec 7, 2021
Happy to share our latest open-access review on how tissue context creates diverging challenges for tissue #macrophages to fulfill their role in homeostasis and pathology. We outline #metabolic adaptations of tissue macrophages. rdcu.be/cCL4W nature.com/articles/s4142…
David Sancho
@SanchoLab
Sep 27, 2020
We offer a 4-year PhD contract linked to a funded project about immunometabolism of myeloid cells and focused on metabolomics studies. Thanks for spreading the word! Full info in the attachment About @SanchoLab: cnic.es/en/investigaci… About @CNIC_CARDIO: cnic.es
David Sancho
@SanchoLab
Oct 26, 2023
🚨🚨 POSTDOC ADVERT!!! We offer a postdoc position focused on metabolism of macrophages and dendritic cells and their targeting for immunotherapy of cardiovascular diseases. I will be very grateful if you can distribute the advert🙏 cnic.es/en/investigaci…
40K
David Sancho
@SanchoLab
Feb 7, 2024
Our latest review on DCs in anticancer immunity @NatRevClinOncol updates on DC lineages and states in the tumor in the single-cell era, diversity in different human cancers, clinical trials, DCs in current & future cancer immunotherapy. Free link: rdcu.be/dx3MA
NatureRevClinOncol
@NatRevClinOncol
Feb 7, 2024
This new Review describes the roles of dendritic cells (DCs) as orchestrators of anticancer immunity, focusing on novel insights on DC heterogeneity gleaned from single-cell studies & how this knowledge might be leveraged to improve immunotherapy: nature.com/articles/s4157…
20K
David Sancho
@SanchoLab
Apr 15, 2025
🚨Put a dendritic cell (DC) in your tumor #immunotherapy! cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! @CNIC_CARDIO @AgEInves @contracancerINV @FundlaCaixa @WorldwideCancer
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor...
From nature.com
11K
David Sancho
@SanchoLab
May 18, 2024
🚨FREE LINK to our latest review on metabolism of tissue macrophages depending on LOCATION AND AGE: authors.elsevier.com/a/1j6Zt3jDgWq3… Tissue-resident #macrophage #metabolismis diverse across organs to support distinct tissue functions. #Aging deregulates this balance: #inflammaging
20K
David Sancho
@SanchoLab
Dec 18, 2023
🚨Dendritic cell lovers!🚨 Mark in your calendar the 17th International symposium on DCs in #DC2024Barcelona (20-23 October 2024). Please, check the webpage dc2024barcelona.com with the preliminary program! Thanks to our fantastic speakers for accepting the invitation! 👇🏻👇🏻👇🏻
23K
David Sancho
@SanchoLab
Sep 18, 2020
1. Happy to share our latest work @NatMetabolism on how Fgr kinase connects #macrophage #mitochondrial #metabolism with whole body metabolism, a work led by @R_AcinPerez & @salva_iborra at @SanchoLab & @GenoxphosLab nature.com/articles/s4225… Free link: rdcu.be/b7lrk 👇
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity
From nature.com
David Sancho
@SanchoLab
Jan 23, 2025
OPEN @ImmunityCP cell.com/immunity/fullt… Fat diet, dysbiosis, pathogens, inflammation & chemicals induce gut barrier disruption! We find that systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells (1/8)
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training...
From cell.com
17K
David Sancho
@SanchoLab
Oct 17, 2021
Great paper @GerhardKronke showing IL-33-IL1RL1-p38 MAPK-mediated translocation of UCP2, leading to mitochondria uncoupling, itaconate accumulation and GATA-3 activation that differentiates alternatively activated macrophages for inflammation resolution
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated...
From cell.com