Rong Fan (@RongFan8) / X

Rong Fan

6,576 posts

Rong Fan

@RongFan8

Harold Hodgkinson Professor of Biomedical Engineering and Pathology, Yale University. *Personal Account*. Views are my own.

Connecticut, USA

seas.yale.edu/faculty-resear…

Joined September 2017

Pinned
Rong Fan
@RongFan8
Jan 28, 2025
Just picked up the beautiful offprint of our Patho-DBiT paper that was on the cover of @CellCellPress, highlighting its power to spatially explore molecular biology in human FFPE tissues 🤩🤩 . Congratulations to my phenomenal postdoc @Zhiliang_Bai and all amazing collaborators!!
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Rong Fan
@RongFan8
Mar 15, 2023
Spatial epigenome–transcriptome co-sequencing🤩🤩🤩Beyond excited to see it out today @Nature! Enjoyable collaboration between my lab @YaleBme @YaleSEAS @YaleMed and @GoCasteloBranco of @karolinskainst. The most informative tool for spatial multi-omics!! nature.com/articles/s4158…
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Rong Fan
@RongFan8
Aug 17, 2022
Here comes "spatial-ATAC-seq"!!! A wonderful collaboration between my lab at @YaleSEAS and @GoCasteloBranco at @karolinskainst #epigenetics #spatialomics #spatialbiology Spatial profiling of chromatin accessibility in mouse and human tissues | Nature
Spatial profiling of chromatin accessibility in mouse and human tissues
From nature.com
Rong Fan
@RongFan8
Sep 30, 2024
Thrilled to report Patho-DBiT, just published in Cell 😊. It allows us to directly “see” all kinds of RNA species on the same clinical FFPE tissue slide, including mRNA, miRNA, snRNA, snoRNA, tRNA, etc, and splicing isoforms, genetic alterations (SNV, CNV, etc). Really a fun,
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Rong Fan
@RongFan8
Feb 10, 2022
Spatial-CUT&Tag! @ScienceMagazine, unfolding a new chapter of #spatialomics 🤗 . From my phenomenal postdoc @DengYanxiang of @YaleSEAS @YaleBME, @yalepathology @YaleMed @YaleCancer Thanks to awesome collaborators @GoCasteloBranco @marekbartosovic @PKukanja
science.org
Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level
Spatial-CUT&Tag enables genome-wide tissue mapping of chromatin modification states at a cellular level.
Rong Fan
@RongFan8
Feb 23, 2023
Thrilled to see our new paper out in @NatureBiotech . Spatial-CITE-seq: spatially resolved co-indexing of transcriptome and epitopes for multi-omics sequencing. Big shoutout to Yang Liu, my former postdoc @YaleBme and now assistant professor of pathology and neurology @YaleMed !
Nature Biotechnology
@NatureBiotech
Feb 23, 2023
High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq go.nature.com/3koGTTC
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Rong Fan
@RongFan8
Nov 13, 2020
Today is the day!!! Our DBiT-seq work is out in Cell. This is a fundamentally new approach in this space. It may unlock a wide range of spatial omics technologies. The limit is only our imagination ^_^
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue
From cell.com
Rong Fan
@RongFan8
Sep 25, 2024
Today is the day 🤩. Thrilled to share our @Nature paper on Th2 function, CAR-T, & 8-year remission!⁩! Huge team effort w/⁦@GruppSteve⁩ ⁦⁦@carlhjune⁩ ⁦@MelenhorstLab⁩ ⁦@Tang_Lab_EPFL⁩, kudos to my postdoc ⁦@Zhiliang_Bai⁩
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
From nature.com
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Rong Fan
@RongFan8
Feb 9, 2024
🤩🤩🤩 Spatial Omics fans, I am super excited to share our latest manuscript!!! 🤩🤩🤩 #spatialomics #spatialbiology #singlecell Spatially Exploring RNA Biology in Archival Formalin-Fixed Paraffin-Embedded Tissues
biorxiv.org
Spatially Exploring RNA Biology in Archival Formalin-Fixed Paraffin-Embedded Tissues
Spatial transcriptomics has emerged as a powerful tool for dissecting spatial cellular heterogeneity but as of today is largely limited to gene expression analysis. Yet, the life of RNA molecules is...
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Rong Fan
@RongFan8
Jun 7, 2021
Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular level. #spatialomics #spatialbiology Collaboration w/ @GoCasteloBranco @Halene_lab, Sai Ma, Joe Craft, and Mina Xu. Kudos to @DengYanxiang
biorxiv.org
Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale...
Cellular function in tissue is dependent upon the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context. The emergence of spatial transcriptom...
Rong Fan
@RongFan8
Nov 5, 2025
Thrilled see our paper out in @Nature ! 🤩 Wonderful collaboration with @GoCasteloBranco. Kudos to my amazing postdoc @Di_0579 at @YaleEngineering and Leslie Kirby from Goncalo's lab @karolinskainst. Huge team science with @YaleMed @UCSF @ASTARsg
Spatial dynamics of brain development and neuroinflammation
From nature.com
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Rong Fan
@RongFan8
Dec 6, 2024
Spatial Omics enthusiasts!! Spatial Proteomics is the Method of the Year 2024 🤩🤩🤩
nature.com
Nature Methods - Method of the Year 2024: spatial proteomics
Spatial proteomics is our pick for Method of the Year 2024. The cover illustrates cellular neighborhoods within tumors, revealing the diverse and complex...
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Rong Fan
@RongFan8
Feb 19, 2022
What an exciting week for CUT&Tag!!! After we published spatial-CUT&Tag in Science last week, Prof. Xiaowei Zhang lab demonstrated combining CUT&Tag and MERFISH to image, for example, 127 target H3K4me3 loci or 139 H3K27ac loci in mouse brain. Very cool!
biorxiv.org
Spatially resolved epigenomic profiling of single cells in complex tissues
The recent development of spatial omics methods enables single-cell profiling of the transcriptome and the 3D genome organization in a spatially resolved manner. Expanding the repertoire of spatial...
Rong Fan
@RongFan8
Feb 24, 2024
Super-resolved single-cell atlas of a human lymphoma FFPE tissue slide profiled using our latest Patho-DBiT technology and the novel pipeline iStar developed by @DrMingyaoLi . Just too psyched to not share 🤩🤩
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