Can one distill systemic therapy of gastroenteropancreatic NETs down to one slide...? Preparing for AHPBA next week. I have 8 min to cover systemic therapy of NETs. The final slide works better in presentation mode but here it is. Anything missing...? #neuroendocrinetumors
Thor Halfdanarson
3,851 posts
🇮🇸Medical Oncologist/Educator, NET/GI/CUP enthusiast. Husband/dadx4 (bad dad jokes). Cyclist. Avant gardener. Professor of Oncology, Mayo Clinic. Tweets mine.
- A true story: in the NET clinic today. Clinical dilemma. I’m stumped (that happens sometimes). I emailed 5 incredibly experienced NET colleagues, 4 in Europe and one in the US. Every single one got back within 6 hours. I absolutely love the academic NET community 😍 So thankful.
- Dear friends, sincerest thanks for the trust and thanks to @PamelaKunzMD for model leadership. I could not have had a better mentor for this role. Very much looking forward to a bright @NANETS1 future in an organization packed with incredible individuals. Onwards and upwards!Congratulations Mr President @OncoThor! And thanks @PamelaKunzMD for your leadership over the last year and taking the society to the next level. Can’t wait to see what’s next for @NANETS1 ✨
- Can the therapy of grade 3 neuroendocrine neoplasms be distilled down to a single slide? Not sure, but here is my attempt for the upcoming NANETS Regional Conference in Mexico City next weekend... Lots of low-ish quality data and I left out the NABNEC data on nab-pacli + carbo.
- Masterclass presentation on the management of advanced colorectal cancer from @GIcancerDoc at the inaugural Mayo Clinic Heme/Onc Board Review and Practice Update conference this week. Can he fit it in one slide...? He sure can! Don't miss this next year. tinyurl.com/rh7c927c
- Can I summarize the watchful waiting principles of nonfunctional small (≤ 2 cm) pancreatic NETs in 1 slide. Got a talk coming up. Anything I am missing here? What is the highest tumor grade appropriate for watching? Ki67 up to 10%? Up to 20%? What I am missing here? @spartelli
- Saw a patient with resected panc NET last month. 6 month postop chromogranin A >50 times upper limit of normal (>5000). Stopped PPI, CgA normalized. Beware, not all elevated CgA is from NETs... Highest CgA elevation I’ve seen from PPI thus far
- To operate or not on panc NETs <2 cm…? The answer is NOT. Excellent presentation by @spartelli on the long term outcomes of the ASPEN trial. Almost 1000 patients observed w/o resection and progression was uncommon, mets rare and survival the same as with resection.
- See you next year, dear San Francisco for the 2023 ASCO GI Cancers Symposium. #GI22
- A very important trial showing impressive PFS difference favoring PRRT. Read after me: NETs are NOT rare anymore (the second most prevalent GI cancer according to some studies) and we can very successfully conduct phase III trials in this population.NETTER-2 reports significantly improved PFS in Ki67 10-55% GEP-NETS with first-line #Lutathera vs ⬆️ dose SSA, HR 0.27. Similar benefit in subgroups. #GI24 @LACNETS @CarcinoidNETs @OncoThor
- Another outstanding study led by @HallberaG of @MayoSurgery. More than 500 NET pts who underwent liver resection. Symptom relief in 96% of pts w/ functional NETs w/ durable symptom control. 122 month OS (!!) with 90-day mortality of 1.6%. link.springer.com/article/10.124…
- Trying to summarize nuanced treatment decisions in one slide... What to do with small NF-pNETs? Who to observe? When to intervene...? What am I missing/getting wrong...? Paging my surgery friends @HalletJulie @spartelli @DrCNClarke @TELL_Starlinger @ThielsCA @Seanpcleary
- What a time to be alive! Fantastic review of therapy options for NSCLC by @RManochakian . This and so much more at the Mayo Hematology and Oncology Board Review and Practice Update. Don't miss it in the future. All your review needs in heme/onc covered. tinyurl.com/rh7c927c





















