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NatureStructMolBiol
@NatureSMB
Nature Structural & Molecular Biology publishes top-quality research providing insight into how molecular components work together in biological processes.
nature.com/nsmb/
Joined October 2015
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    NatureStructMolBiol
    @NatureSMB
    Jun 13, 2025
    We are hiring a new editor! If you want to join the Nature Structural & Molecular Biology team and help publish exciting research, please apply. Deadline is June 20th. More information here: springernature.wd3.myworkdayjobs.com/SpringerNature…
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    NatureStructMolBiol
    @NatureSMB
    Aug 26, 2019
    Anthony Roberts & co report a #cryoEM structure of dynein-2 complex, suggesting mechanisms behind autoinhibition and transport on anterograde IFT trains nature.com/articles/s4159… With News & Views by Susan Dutcher
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    NatureStructMolBiol
    @NatureSMB
    Jan 20, 2022
    Can AlphaFold2 predict the impact of missense mutations on structure? Correspondence by @kyliejwalters & Gwen Buel: nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Aug 10, 2021
    AlphaFold2 and the future of structural biology: Patrick Cramer @CramerLab @mpi_bpc discusses the recently launched #AlphaFold2 by @DeepMind and how it will impact structural biology. nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Jun 22, 2021
    #cryoEM structures of SARS-CoV-2 ORF3a, an ion channel conserved in coronaviruses and a potential new drug target for #COVID19. Work by @SteveBrohawn @Bautista_DianaM @AbhayKot @kerndm @chrismhoel et al. @berkeleyMCB nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Jun 5, 2019
    Crowdsourcing success @UWproteindesign! Foldit players design f 56 new stable proteins from scratch, representing 20 different folds, including one not observed in natural proteins. Four newly determined structures validate the designs. nature.com/articles/s4158…
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    NatureStructMolBiol
    @NatureSMB
    Sep 6, 2021
    #cryoEM structure of human mitochondrial RNase P bound to precursor tRNA reveals the molecular basis for first step of RNA processing in human mitochondria. Work by @hauke_hillen @BhattaArjun2p @c_dienemann @CramerLab @mpi_bpc nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Aug 5, 2021
    A #cryoEM structure of the active human melatonin receptor #GPCR in complex with Gi reveals conformational changes upon activation and basis for G-protein selectivity. Work from the Nureki, Inoue (@TohokuSeika) and Nishizawa labs led by @hhokamoto_en nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Sep 30, 2019
    See movie, courtesy of Matthias Wolf
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    NatureStructMolBiol
    @NatureSMB
    Sep 30, 2019
    Wolf @oistedu, Aizawa and colleagues use #cryoEM to reveal 11 different conformations in the curved flagellar hook nature.com/articles/s4159… See also NV from Ed Egelman nature.com/articles/s4159… , covering this and related work from the Namba group.
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    NatureStructMolBiol
    @NatureSMB
    Aug 22, 2023
    🐱🧬AUGUST ISSUE IS OUT! 🧬🐱 X-chromosome inactivation - insights from the active and inactive X chromosome We featured 3 papers on the cover, which investigate the molecular mechanisms of dosage compensation in mammals. issue: nature.com/nsmb/volumes/3…
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    NatureStructMolBiol
    @NatureSMB
    May 1, 2022
    Biochemical and cell-based assays reveal that PARP inhibitors impede maturation of nascent DNA strands during replication and implicate unligated Okazaki fragments and other nascent strand discontinuities in the cytotoxicity of these anti-cancer compounds. nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Nov 25, 2019
    How poly(A) stops ribosomes in their tracks nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Nov 14, 2021
    #NMR & direct visualization of phase-separated FUS and Pol II domains in models of transcription condensates show a wider array of residue types & interactions that stabilize phases. Work by @Nicolas_Fawzi @BrownUResearch @CarneyInstitute @TAMUengineering nature.com/articles/s4159…
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    NatureStructMolBiol
    @NatureSMB
    Apr 23, 2022
    Biochemical and cell-based assays reveal that PARP inhibitors impede maturation of nascent DNA strands during replication and implicate unligated Okazaki fragments and other nascent strand discontinuities in the cytotoxicity of these anti-cancer compounds. nature.com/articles/s4159…