NEJM Evidence (@NEJMEvidence) / X

NEJM Evidence

3,480 posts

NEJM Evidence

@NEJMEvidence

NEJM Evidence, a journal from NEJM Group, presents innovative Original Research and fresh, bold ideas in Clinical Trial design and clinical decision-making.

Boston

Joined August 2021

Pinned
NEJM Evidence
@NEJMEvidence
Apr 4
Among patients with carpal tunnel syndrome randomized to a rigid wrist splint versus placebo bandage, 12-week change in symptom scores was not significantly different and proportion undergoing surgery within 1 year was similar between the two groups. eviden.cc/4rFztrz
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NEJM Evidence
@NEJMEvidence
Dec 18, 2024
How do we make sense of two “negative” trials in @NEJM and a “positive” meta-analysis of the two trials in NEJM Evidence? @emil_hs and @FralickMike share some insights in this editorial: eviden.cc/3OYutgJ
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NEJM Evidence
@NEJMEvidence
Mar 23, 2023
Osmotic demyelination syndrome (ODS) following correction of hyponatremia was studied in 22,858 hospitalizations. There were 12 cases of ODS identified, only half of which occurred following rapid correction of serum sodium. #IMTwitter #NeuroTwitter
ODS in Patients Hospitalized with Hyponatremia
From nejm.org
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NEJM Evidence
@NEJMEvidence
Apr 13, 2023
“A 48-hour limit of sodium correction of 15 to 20mmol/l would be more useful than the current 24-hour limits of between 8 and 10mmol/l per 24 hours, as it would allow more room for active therapy with a safe limit for correction.” eviden.cc/3JUrILQ #IMTwitter
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NEJM Evidence
@NEJMEvidence
Feb 7, 2025
Cardiorespiratory fitness is an indicator of future cardiac, metabolic, and health events and is a strong predictor of all-cause mortality. 🏃 @BrazileTiffany and colleagues review the basics of the cardiorespiratory response to exercise. Full article: eviden.cc/3Pe9Ay8
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NEJM Evidence
@NEJMEvidence
Mar 7, 2025
Cardiopulmonary exercise testing (CPET) has a unique role in the assessment of cardiopulmonary disease. @BrazileTiffany and colleagues review key CPET variables, protocols and clinical indications. eviden.cc/4aC6uOt
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NEJM Evidence
@NEJMEvidence
Jan 27, 2022
A neonate was delivered at 39 weeks of gestation. He cried immediately after birth, but his whole body appeared blue. A team from @ChildrensPhila reviews their approach to the differential diagnosis in this #MorningReport. @amyjromer #MedEd #NeoTwitter eviden.cc/32i1902
NEJM Evidence
@NEJMEvidence
Jan 18, 2022
“Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis (#PLUS),” an Original Article by @naomihammond et al., is now available. @CritCareReviews @georgeinstitute #CriticalCare #ClincialTrials eviden.cc/3HWUyaC
NEJM Evidence
@NEJMEvidence
Jan 25, 2022
DREAM trial: In this pragmatic #RCT in active young adults with meniscal tears, early meniscal surgery was not superior to a strategy of supervised exercise therapy and education with the option of later surgery. @STSkou #OrthoTwitter #SurgTwitter eviden.cc/3fFOHdI
NEJM Evidence
@NEJMEvidence
Jan 24, 2025
In the absence of randomized trials, the question “How should elevated blood pressure be managed in hospital?” is hard to answer. 🩸 The authors pitch a future trial to answer this timely question. Full article: eviden.cc/3CHMv4c
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NEJM Evidence
@NEJMEvidence
Jan 6, 2023
This prospective study tested use of home waking salivary cortisone levels to predict adrenal insufficiency. Salivary cortisone had diagnostic accuracy similar to that of a standard adrenocorticotropin (ACTH) stimulation test. eviden.cc/3GHaobt #EndoTwitter #MedTwitter
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NEJM Evidence
@NEJMEvidence
Jun 25, 2022
“Hypothermia at 33°C did not decrease 6-month mortality compared with normothermia after out-of-hospital cardiac arrest.” Read more about the recently published meta-analysis by Johan Holgersson, MD, Martin Abild Stengaard Meyer, MD, et al.: eviden.cc/3mRVOTG #CriticalCare
NEJM Evidence
@NEJMEvidence
Jan 31, 2024
“…‘statistically significant’ estimates tend to seriously overestimate actual treatment effects, ‘nonsignificant’ results often correspond to important effects, and efforts to replicate often fail to achieve ‘significance’….” Read the full article: eviden.cc/3NrObRI
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NEJM Evidence
@NEJMEvidence
Jan 6, 2023
Exercise is strongly associated with ⬇ morbidity and mortality. However, large amounts of endurance exercise may have adverse effects. Thompson and colleagues review the evidence on the health effects of high-volume exercise training. eviden.cc/3hLAWyH #CardioTwitter
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