The Muir Lab (@MuirLab) / X

The Muir Lab

143 posts

The Muir Lab

@MuirLab

The Muir lab investigates the physiochemical basis of protein function in complex systems of biomedical interest.

Princeton, NJ

Joined July 2021

Pinned
The Muir Lab
@MuirLab
Apr 28
Check out our latest efforts published in @ChemicalScience on characterizing and engineering the NrdJ-1 intein for protein biochemistry and chemical biology applications! Congrats to @XuanjiaYe, Josh, Christian, @thegoodnush and Juner! @PrincetonChem
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The Muir Lab
@MuirLab
Apr 5, 2023
Looking to study chromatin interactomes with proximity labeling? Check out our new paper in @Nature, where we combine our split-intein expertise with uMap technology from the @MacMillan_Lab to map the microenvironment of chromatin state changes. nature.com/articles/s4158…
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The Muir Lab
@MuirLab
Apr 10, 2023
Today we introduce Light-induced Interactome Tagging (LITag) in @PNASNews, where we use light to activate a genetically-encoded LOV protein for second-scale proximity labeling. Congrats to authors @HananyaNir, Xuanjia, and @ShanyKoren!
pnas.org
A genetically encoded photoproximity labeling approach for mapping protein territories | PNAS
Studying dynamic biological processes requires approaches compatible with the lifetimes of the biochemical transactions under investigation, which ...
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The Muir Lab
@MuirLab
Nov 22, 2023
Check out our latest review in @NatureRevGenet summarizing the use of designer chromatin to study fundamental epigenetic mechanisms. Congrats to @HananyaNir and @ShanyKoren! go.nature.com/3umu7K3
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The Muir Lab
@MuirLab
Apr 30, 2024
Congratulations to our newest inductee into the @theNASciences! @PrincetonChem
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The Muir Lab
@MuirLab
Jul 9, 2024
Check out our latest paper in @nchembio, where we developed our CAGE split intein platform to study signaling events using proteomic profiling. This enables insights into the differential molecular connections of fusion oncogenes. Congrats to @GihoonLee1! nature.com/articles/s4158…
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The Muir Lab
@MuirLab
Jun 4, 2024
Ever wanted to swap out an entire internal region of a folded protein for functional biochemical studies? Check out our preprint that has been 5 years in the making, in which we establish a protein editing platform via protein transposition, enabling the insertion of functional
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The Muir Lab
@MuirLab
Apr 26, 2024
Congratulations to our postdoc @jeremyaowen on becoming a @DamonRunyon Quantitative Biology fellow!
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The Muir Lab
@MuirLab
Apr 3, 2025
The final version of our protein transposition manuscript is now published in @ScienceMagazine science.org/doi/10.1126/sc… We’ve added a few new things since our preprint /1
science.org
Protein editing using a coordinated transposition reaction
Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding...
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The Muir Lab
@MuirLab
Dec 14, 2021
The Muir lab gets festive with an ugly Christmas sweater celebration
The Muir Lab
@MuirLab
May 30, 2025
Congratulations to our trailblazing leader!
Princeton Chemistry
@PrincetonChem
May 30, 2025
Proud to announce that Tom Muir has been awarded the 2025 Bristol Myers Squibb Award in Enzyme Chemistry and Chemical Biology from the ACS Division of Biochemistry and Chemical Biology. Congratulations Tom! Announcement: bit.ly/4dBxNtM
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The Muir Lab
@MuirLab
Jul 29, 2021
Check out the latest review from the Muir lab on various methods for making asymmetric nucleosomes and their biological significance. This is taking the concept of a “histone code” to the next level! @MMMitchener @PrincetonChem pubs.acs.org/doi/10.1021/ac…
The Muir Lab
@MuirLab
Jul 16, 2021
In collaboration with @kadochlab, we use DNA-barcoded nucleosome technology to uncover histone post-translational modifications that are determinants in chromatin binding and remodeling activity of the BAF complexes. @ongnghiem @CKadoch @NMashtalir science.sciencemag.org/content/373/65…
The Muir Lab
@MuirLab
Oct 4, 2022
Exciting work with the @DavidCowburn1 group out today. Please check it out! Thank you @dr_gigster, @stevenschem, @LabMostafavi and Pulikallu for your hard work.
A Conserved Histidine Residue Drives Extein Dependence in an Enhanced Atypically Split Intein
From pubs.acs.org