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Luke Koblan
@LukeKoblan
K99/R00 fellow at @WhiteheadInst in @JswLab | Helen Hay Whitney Fellow | Chemical Biology PhD @Harvard in @liugroup
Joined January 2017
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  • user avatar
    Luke Koblan
    @LukeKoblan
    Feb 14, 2025
    Just received the word that my K99/R00 is officially funded! Huge thanks to my mentors, colleagues, and friends in science who’ve helped me get here. Excited for the science ahead– stay tuned! Nice to share good personal news and hope for those waiting on word from the NIH ◡̈
    26K
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jun 29, 2021
    Today we published our paper in @NatureBiotech describing novel C to G base editors (CGBEs). This project started in my first year of graduate school and took a bit to get across the finish line. We started making CGBEs by taking advantage of an observation that C to T...
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jun 16, 2025
    1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse
    biorxiv.org
    High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
    Charting the spatiotemporal dynamics of cell fate determination in development and disease is a long-standing objective in biology. Here we present the design, development, and extensive validation...
    87K
  • user avatar
    Luke Koblan
    @LukeKoblan
    Dec 1, 2021
    Some good news! I was lucky enough to be selected to the @Forbes 30 Under 30 in Healthcare for 2022. Many thanks to my amazing advisor @davidrliu and my many fantastic mentors including @CKadoch, @zhangf, Steve Elledge, @jaybradner, @NIHDirector @JswLab
    Forbes 30 Under 30 2022: Healthcare
    From forbes.com
  • user avatar
    Luke Koblan
    @LukeKoblan
    Aug 1, 2025
    I'll be out at Stanford this coming Thursday hosted by my friend and collaborator @weallen1 where I'll be presenting a seminar on our recent PEtracer work (science.org/doi/10.1126/sc…) Feel free to swing by-- info attached!
    10K
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jan 6, 2021
    Our work describing the use of adenine base editing to correct the most common genetic cause of Hutchinson-Gilford Progeria Syndrome was published today! Check out the paper here:
    Content cover image
    In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice
    From nature.com
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jul 24, 2025
    Excited to announce that this work is now live as a first release article @ScienceMagazine So grateful for this fantatic team and to see this work in wild!
    user avatar
    Luke Koblan
    @LukeKoblan
    Jun 16, 2025
    1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse
    science.org
    High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
    Charting the spatiotemporal dynamics of cell fate determination in development and disease is a long-standing objective in biology. Here, we present the design, development, and extensive validation...
    45K
  • user avatar
    Luke Koblan
    @LukeKoblan
    Feb 26, 2021
    Just finished my last day working in @davidrliu’s lab! I have learned so much from David and my @liugroup colleagues. I’m heading next door to start my postdoctoral work in the @JSWlab! Any tips on how to make new friends in your late 20s would be greatly appreciated...😁
  • user avatar
    Luke Koblan
    @LukeKoblan
    Apr 8, 2021
    Our recent publication was reviewed in NEJM today! @davidrliu, @NIHDirector, @JonBrownLabVUMC, @Progeria, @mrrerdos The figure is absolutely killer! Will definitely be sending this to my mom.
    nejm.org
    Base Editing in Progeria | NEJM
    The Hutchinson–Gilford progeria syndrome is an autosomal dominant disease caused by a single point mutation in LMNA, which encodes the lamin A and C proteins. Recent experiments have shown that lif...
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jun 28, 2021
    This was the product of a fantastic collaboration between @liugroup @davidrliu @JswLab @bsadamson! Looking forward to seeing everyone's thoughts!
    user avatar
    Nature Biotechnology
    @NatureBiotech
    Jun 28, 2021
    Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning go.nature.com/3dmAjWZ
  • user avatar
    Luke Koblan
    @LukeKoblan
    May 30, 2022
    An exciting weekend celebrating my fiancé’s graduation from HBS! Had to snag some pictures in our fancy graduation garb 🎓
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jan 6, 2021
    I am incredibly thankful to have worked with such an amazing team led by @davidrliu, @JonBrownLabVUMC, and @NIHDirector with amazing contributions from Leslie Gordon at the PRF (@progeria) and all of our co-authors (especially my co-first author Mike Erdos)
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jan 28, 2021
    Another fun article about the progeria work at the Harvard Gazette. My mom is very excited about this one as it has a picture of me in it (which my fiancé took in our living room as I still do not have a professional headshot)😅 I'm an adult, I swear!
    Progeria study finds base-editing therapy lengthens lifespan in mice
    From news.harvard.edu
  • user avatar
    Luke Koblan
    @LukeKoblan
    Jul 24, 2024
    An article in today’s @nytimes provides a small glimpse at the incredible progeria community. The hard work, dedication, and energy of the amazing patients and the thoughtful scientific leaders have made all of the progress in this field possible. It is such an honor to be a
    1.9K