Eric Betzig (@Eric

Eric Betzig

1,114 posts

Eric Betzig

@Eric_Betzig

An engineering physicist sometimes masquerading as a biologist or, on one occasion, a chemist. Aspiring astronaut. Nuclear is the way.

Joined December 2023

Eric Betzig
@Eric_Betzig
Jul 19, 2024
#cellbiology #bioart The actin #cytoskeleton (green) is linked to a variety of transmembrane proteins through alpha-actinin (magenta), with such linkages being particularly dense in membrane ruffles and filopodia. As seen at 3 frames/min for 8 min by linear and non-linear
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Eric Betzig
@Eric_Betzig
Aug 3, 2024
#FluorescenceFriday #cellbiology 3D dynamics of six organelles in a COS-7 cell as revealed by lattice #lightsheet microscopy with multichannel unmixing. In collaboration with @Valm_Lab and @cohenlaboratory, then in @JLS_Lab. doi.org/10.1038/nature…
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Eric Betzig
@Eric_Betzig
Sep 27, 2024
Relationship between chromosomes (orange) and the mitotic spindle (green) in four stages of cell division, as seen by Bessel Beam plane structured illumination microscopy cell.com/fulltext/S0092…
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Eric Betzig
@Eric_Betzig
Aug 29, 2025
Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.
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Eric Betzig
@Eric_Betzig
Apr 17, 2024
Amen. When I interviewed at Bell Labs at the end of graduate school, I was asked to prepare a 45 min talk that took me 90 min to deliver -- thanks to all the interrupting questions and debate that ensued. It was fantastic! It meant that they cared, and they pushed me in
Physics In History
@PhysInHistory
Apr 17, 2024
Karl Popper (1902-1994) on what it means to be a rationalist ✍️ When I speak of reason or rationalism, all I mean is the conviction that we can learn through criticism of our mistakes and errors, especially through criticism by others, and eventually also through self-criticism.
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Eric Betzig
@Eric_Betzig
Mar 29, 2024
#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the
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Eric Betzig
@Eric_Betzig
May 10, 2024
#FluorescenceFriday #cellbiology #bioart A neutrophilic cell migrating through a 3D collagen mesh at 1.3 sec intervals for 5.5 min, as seen by lattice light sheet microscopy. doi.org/10.1126/scienc…
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Eric Betzig
@Eric_Betzig
Aug 14, 2025
MOSAIC lattice light sheet xy projection over 2+ hrs in human retinal pigment epithelial cells of endoplasmic reticulum remodeling (cyan) and transport of vesicles (yellow) containing β4-galactosyltransferase....
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Eric Betzig
@Eric_Betzig
Aug 10, 2025
MOSAIC large field of view 3D single molecule localization microscopy of mitochondrial outer membranes and nuclear membranes in fixed U2OS cells.
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Eric Betzig
@Eric_Betzig
Apr 12, 2024
#FluorescenceFriday #cellbiology #bioart The actin cytoskeleton at 60 nm resolution and 3 frames/min, and its association with early endosomes (Rab5a, green), as seen in a COS-7 cell by photoactivated nonlinear structured illumination microscopy doi.org/10.1126/scienc…
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Eric Betzig
@Eric_Betzig
Jun 7, 2024
#FluorescenceFriday #cellbiology #microtubules 1/3 Today, three views of microtubule (MT) growth dynamics by two different microscopes. First up, top and side views of growing MT plus ends at 1.2 volumes/sec in a HeLa cell in S phase for 150 time points, as seen by lattice light
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Eric Betzig
@Eric_Betzig
Aug 10, 2024
10/ With adaptive optical lattice light sheet microscopy (AO-LLSM), we’ve opened a stunningly beautiful and humblingly complex world of 4D subcellular processes viewed with high definition in living transparent multicellular organisms such as zebrafish. science.org/doi/10.1126/sc…
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Eric Betzig
@Eric_Betzig
Jun 14, 2024
#FluorescenceFriday #zebrafish #bioart To see cells as they really are, it's necessary to see them in the native multicellular environment in which they evolved. However, the deeper we peer into living tissue, the more our view is obscured by optical aberrations. Here, take a
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Eric Betzig
@Eric_Betzig
Feb 23, 2024
Hair-like filopodia, seen in this side view of a HeLa cell, contribute to their exceptional motility and proliferative ability. As seen by 3D lattice light sheet structured illumination microscopy. #FluorescenceFriday #Science @WorldAndScience science.org/doi/10.1126/sc…
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