Sarah Cohen (@cohenlaboratory) / X

Sarah Cohen

2,453 posts

Sarah Cohen

@cohenlaboratory

Associate Professor of Cell Biology and Physiology @UNC. Interested in lipids, organelles, and light microscopy. Alumnus of @JLS_Lab and @ubclifesciences

Chapel Hill, NC

cohenlaboratory.web.unc.edu

Joined October 2017

Pinned
Sarah Cohen
@cohenlaboratory
Feb 16
I'm delighted to present TWO new preprints from my lab, led by @MC_Zanellati and @ChihHsuanHsu1, about how #organelles remodel throughout #NeuronalDifferentiation. Check out the tweetorials about their papers below:
Sarah Cohen
@cohenlaboratory
Feb 16
Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13
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Sarah Cohen
@cohenlaboratory
Feb 4, 2022
I am so excited to share my lab’s first preprint! Led by Greg Miner, we take a dive into the function of #LipidDroplet-#mitochondria contact sites: 1/11
biorxiv.org
Perilipin 5 interacts with Fatp4 at membrane contact sites to promote lipid droplet-to-mitochondria...
Cells adjust their metabolism by remodeling membrane contact sites that channel metabolites to different fates. Lipid droplet (LD)-mitochondria contacts change in response to fasting, cold exposure,...
Sarah Cohen
@cohenlaboratory
Sep 28, 2023
Preprint alert! We are happy to introduce Contact-FP, a suite of probes for studying #MembraneContactSite dynamics. This was an amazing team effort led by Research Associate @GregoryMiner18 and postbacc Sidney Smith 1/11
biorxiv.org
Contact-FP: a dimerization-dependent fluorescent protein toolkit for visualizing membrane contact...
Membrane contact sites (MCSs) are sites of close apposition between two organelles used to exchange ions, lipids, and information. Cells respond to changing environmental or developmental conditions...
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Sarah Cohen
@cohenlaboratory
Apr 29, 2023
New preprint from the Cohen lab! Led by @iawindham, we found that astrocyte #APOE can traffic to #LipidDroplets, where it modulates LD composition and size: biorxiv.org/content/10.110… 1/12
biorxiv.org
APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size
The E4 variant of APOE strongly predisposes individuals to late-onset Alzheimer’s disease. We demonstrate that in response to neutral lipid synthesis, apolipoprotein E (APOE) in astrocytes can avoid...
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Sarah Cohen
@cohenlaboratory
Jul 19, 2019
The best way to end the week: with a Notice of Award! I’m thrilled to announce that my lab has been awarded an R35 MIRA from @NIGMS @NIH. We are excited to continue our work on the mechanisms of lipid trafficking within and between cells!
Sarah Cohen
@cohenlaboratory
Nov 2, 2023
Thrilled to have reached a landmark moment for the Cohen Lab: first PhD student defended! Congratulations Dr. Windham @ia_windham!
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Sarah Cohen
@cohenlaboratory
Oct 31, 2022
Today the lab made all my dreams come true by dressing up as multispectral #organelles! Individual photos in the thread below:
Sarah Cohen
@cohenlaboratory
Oct 10, 2019
Super excited to unveil our new lab #logo. Thank you to Sarah Monroe of @DieringLab for her excellent design skills! Open to suggestions for an accompanying tagline.
Sarah Cohen
@cohenlaboratory
Apr 8, 2021
I'm thrilled to present my lab's first research paper on the role of MCTPs in regulating #LipidDroplet biogenesis and growth, led by Amit Joshi @amtya21:
molbiolcell.org
Multiple C2 domain–containing transmembrane proteins promote lipid droplet biogenesis and growth at...
MCTPs can tubulate the ER via reticulon homology domains. They localize to ER subdomains that are sites of lipid droplet (LD) biogenesis. MCTP reticulon homology domains promote LD biogenesis, while...
Sarah Cohen
@cohenlaboratory
Dec 3, 2024
I am honored to be named a 2024 @AllenFrontiers Distinguished Investigator in #Organelle Communication! I'm especially excited to work with @AssafZaritsky and @mattersOfLight to image and model organelle interactions throughout differentiation
Accelerators | Allen Institute
From alleninstitute.org
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Sarah Cohen
@cohenlaboratory
Feb 9, 2024
I’m thrilled to see @ia_windham and team’s work about the trafficking of #APOE to #LipidDroplets published today in @JCellBiol: rupress.org/jcb/article-ab… @ApoEdscvr
Sarah Cohen
@cohenlaboratory
Apr 29, 2023
New preprint from the Cohen lab! Led by @iawindham, we found that astrocyte #APOE can traffic to #LipidDroplets, where it modulates LD composition and size: biorxiv.org/content/10.110… 1/12
rupress.org
APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size
Windham et al. discover that APOE in astrocytes can traffic to lipid droplets (LDs), where it modulates LD composition and size. Astrocytes expressing the
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Sarah Cohen
@cohenlaboratory
Jun 7, 2023
I am thrilled to see Greg Miner and team’s work on the role of PLIN5-FATP4 membrane contact sites in #LipidDroplet to #Mitochondria fatty acid transport published today in @Dev_Cell: authors.elsevier.com/a/1hCz%7E5Sx5g… 1/5
Sarah Cohen
@cohenlaboratory
Feb 4, 2022
I am so excited to share my lab’s first preprint! Led by Greg Miner, we take a dive into the function of #LipidDroplet-#mitochondria contact sites: 1/11 biorxiv.org/content/10.110…
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Sarah Cohen
@cohenlaboratory
Sep 10, 2020
I’m thrilled that PhD student Ian Windham @ia_windham and Postdoc Greg Miner have been awarded an NIH F31 and F32, respectively! Seeing trainees succeed so spectacularly is the best part of this job. #NewPISlack #ProudPI
Sarah Cohen
@cohenlaboratory
Oct 31, 2024
Preprint alert! Led by Shannon Rhoads, we used 🌈🔬 to elucidate the #organelle signatures of #neurons and #astrocytes at baseline and in response to neurodegenerative-disease associated stressors. See Shannon's awesome tweetorial below!
Shannon Rhoads
@ShanRhoads
Oct 31, 2024
Check out our preprint using imaging-omics to characterize the #OrganelleSignature - the morphology interactions & distribution of #ER❤️ #Lysosomes🩵 #Mitochondria💚 #Peroxisomes🧡 #Golgi💛 & #LipidDroplets🩷 - of live #neurons and #astrocytes! doi.org/10.1101/2024.1… 🧵1/11
biorxiv.org
Neurons and astrocytes have distinct organelle signatures and responses to stress
Neurons and astrocytes play critical yet divergent roles in brain physiology and neurological conditions. Intracellular organelles are integral to cellular function. However, an in-depth characteri...
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