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Seeking stellar students, postdocs and scientists interested in making a difference in #braintumor and #immunotherapy, #CARTcell. Kicking off my lab @MGHNeurosurg. Please share or reach out for more info!
Bryan D. Choi MD PhD
224 posts
Bryan D. Choi MD PhD
@BryanDChoi
Neurosurgeon and Scientist, Massachusetts General Hospital
- Today, @NEJM published our clinical study of a novel #CARTCell in patients with #Glioblastoma. Early results with CARv3-TEAM-E suggest safety and bioactivity. Special thanks to all collaborators @MGHNeurosurg and @MGHCancerCenter! nej.md/3VnjUIq
- Congrats @StephenBagleyMD @DrORourke2 and colleagues @PennCancer on their manuscript in @NatureMedicine showing safety and early efficacy of bivalent CAR T cells in 18 patients with recurrent #glioblastoma! nature.com/articles/s4159…
- Significant responses to GD2 CAR T cells in multiple patients with diffuse midline glioma, reported by our colleagues @Stanford in @Nature today. Congrats @michelle_monje and co-authors for this giant leap forward in our field! nature.com/articles/s4158…
- Just out in @NatureBiotech, we engineered CAR T cells that secrete BiTEs to more effectively tackle tumor heterogeneity in #glioblastoma. Special thanks to @WTCNeuroscience, @BobCarterMD and most of all @MarcelaMaus for making this possible.
- Congrats @rishabrama and collaborators @MGBneurosurgery on our work developing Meso-CAR T cells for refractory meningiomas, published this week @NeuroOnc! doi.org/10.1093/neuonc…
- A major win for solid tumors; GD2 #CART mediated a 40% complete remission rate in children with high-risk neuroblastoma @NatureMedicine !
- Gliomas with IDH mutations have fewer suppressive myeloid cells, and may set the stage for cell therapy w/ #CARTcells. Awesome work @egrewal1 @LGKRichardson published yesterday in @CCR_AACR @MGHNeurosurg @MGBneurosurgery doi.org/10.1158/1078-0…
- Check out our multivalent CAR T cell study in Neuro-Oncology Advances @EditorNeuro. TanCART eliminated even heterogeneous brain tumors in preclinical models. Congrats to lead author @schmidtsandrea & thanks to all collaborators @MGHNeurosurg @MGHNeuroSci academic.oup.com/noa/advance-ar…
- Phineas Gage's case was a keystone for our first modern theories of frontal lobe function. Original image from @HMSCountway, brought to life by @MyHeritage. Read more about Gage from Dr. Fred Barker @MGHNeurosurg in @TheJNS: thejns.org/view/journals/…
00:00 - Check out this quick read from @NeuroOnc on CART studies for #glioblastoma, all published within a few days of each other by our group and colleagues @PennMedicine and @cityofhope doi.org/10.1093/neuonc…
- Replying to @BryanDChoiOur first preclinical description of this therapeutic strategy was published in @NatureBiotech less than 5 years ago. Excited for this bench-to-bedside story. doi.org/10.1038/s41587…
- Thank you @MGHNeurosurg for a truly great residency! It was a privilege to train with such phenomenal mentors and dedicated colleagues.
- Congrats @LGKRichardson @MGHNeurosurg for his talk and on receiving the Molecular Pathology Award at #SNO2024 @NeuroOnc !
