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Andrew York
@AndrewGYork
I'm a physicist; I develop new microscopy techniques.
San Francisco, CA
andrewgyork.github.io
Joined November 2017
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  • Pinned
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    Andrew York
    @AndrewGYork
    Feb 20, 2018
    Re-imagine scientific publishing. What would you change? My answer: No paywall, no delay, straight to the web. Open data, open code, interactive/animated figures. Transparent, rolling peer review, version control, CCBY license, citable DOIs. See it here: andrewgyork.github.io
  • user avatar
    Andrew York
    @AndrewGYork
    Jul 12, 2023
    We discovered a surprisingly easy way to control the brightness of fluorescent proteins via magnetic fields: andrewgyork.github.io/gfp_magnetoflu… This raises fascinating scientific questions about the mechanism, and tantalizing technological opportunities for bioengineering.
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  • user avatar
    Andrew York
    @AndrewGYork
    Jun 2, 2024
    Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/
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  • user avatar
    Andrew York
    @AndrewGYork
    Jun 13, 2019
    Microscopy technique development's exploding, but core facilities still buy confocals. This ugly baby will end that. Less phototoxicity, WAY faster than confocal. NO DRAWBACK. Details here: andrewgyork.github.io/high_na_single… Co-invented by @amsikking. Get one from [email protected]
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    Andrew York
    @AndrewGYork
    Jan 10, 2022
    Fluorescent biosensors reveal the dynamics of life, but *quantitative* biosensing only works in transparent single cells... until now! andrewgyork.github.io/relaxation_sen… @Maria_Ingaramo figured out how to take robust quantitative measurements with fluorescent biosensors, in whole animals.
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    Andrew York
    @AndrewGYork
    Oct 15, 2019
    I invented this technique. I'd appreciate acknowledgement and citation.
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    Evident Life Science
    @Evident_LS
    Oct 15, 2019
    #WHITEPAPER: Learn the principles behind Olympus Super Resolution (OSR) technology and the optical design of the IXplore SpinSR system - bit.ly/2MfTepi
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    Andrew York
    @AndrewGYork
    Feb 13, 2020
    Help us resolve a paradox, argue with Einstein, and make fluorescence microscopy a thousand times brighter. Ask your favorite physicist: "What direction does stimulated emission travel from a pointlike emitter?" Our answer: andrewgyork.github.io/stimulated_emi… Co-inventor: @sanjay_r_varma
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    Andrew York
    @AndrewGYork
    Aug 23, 2019
    Big update to our single-objective light-sheet project! Spoiler: now you can get a huge field-of-view. Don't like our reference design? Make your own! We've added a general recipe for producing your own custom version: andrewgyork.github.io/high_na_single… (project driven by @amsikking)
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    Andrew York
    @AndrewGYork
    May 12, 2020
    Replying to @AndrewGYork and @acarriebear
    I'm amazed that our community is so insane that pirating our own output via a shady Russian website is effectively best practices. I wonder how many scientist-years of progress scihub is directly responsible for. A hundred? A thousand? Probably more.
  • user avatar
    Andrew York
    @AndrewGYork
    Jan 29, 2020
    Behold the "Scandreas", a trivially-aligned light-efficient alternative to lens-galvo-lens scanning! Invented by Andreas Bodén @Bodeeen1 in @IlariaTesta4's lab, with assistance from @andreavolpato_ (and me!) Video by @Kayley_Hake Cite this tweet: doi.org/10.5281/zenodo…
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    Andrew York
    @AndrewGYork
    Aug 24, 2020
    I'll probably be able to hire 1-2 inventors in the next year or so. For the right person, this is the best science job possible: intellectual freedom, stable/ample funding/salary, and a real chance at impact. Read the rest of this thread to learn why you SHOULDN'T apply...
  • user avatar
    Andrew York
    @AndrewGYork
    May 26, 2020
    How do you share your microscopy data? How should I share mine? How do you use shared microscopy data? @coppola_s_PhD has an idea: let’s write an opinion piece together! @HenriquesLab and I are helping, and we need your help too! Read the rules here: doi.org/10.5281/zenodo…
  • user avatar
    Andrew York
    @AndrewGYork
    Feb 20, 2018
    Replying to @AndrewGYork
    Our second publication, an "open-source hardware" microscope add-on for blazing fast 3D imaging: andrewgyork.github.io/remote_refocus/ Includes raw data, CAD files, parts list, build instructions, figure generation code, and example hardware control code. #OpenSource #OpenSourceHardware
  • user avatar
    Andrew York
    @AndrewGYork
    Nov 25, 2019
    Another update to our single-objective light-sheet project: Proof-of-principle biological imaging! Courtesy of @UTSWNews superstars @RetoPaul, @kD3AN, @ErikWelf and Meghan Driscoll at UTSW. See the first-ever live snoutscope images here: andrewgyork.github.io/high_na_single… CC @amsikking
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