Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacteria infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundr [....] » Read More
Background: Body Mass Index (BMI) remains the cornerstone of cardiometabolic risk stratification. However, growing evidence suggests that BMI inadequately reflects adiposity, metabolic health, and vascular aging across diverse populations. In particular, Asian populations demonst [....] » Read More
Aging is not only driven by the progressive decline of cells and tissues, but also by the spread of biological signals that reinforce dysfunction across the organism. Among these, senescence-associated Extracellular Vesicles (EVs) are emerging as critical mediators of inflammagin [....] » Read More
The medicine of the XXI century is Personalized & Precision Medicine (PPM), by protecting and preserving human health throughout the life. PPM focuses on predictive and preventive measures that contribute to the development of individualized strategies for managing a healthy [....] » Read More
As populations age, enabling independence, safety, and daily functioning for older adults is critical. Robotics, wearable devices, and smart home systems hold tremendous promise, but moving solutions from concept to real-world impact requires validation, user-centered design, and [....] » Read More
Canada is undergoing a historic demographic shift, with nearly one in five Canadians over the age of 65 a proportion set to grow dramatically in the coming decades. This transition presents urgent challenges for health systems, service planning, and public health policy, while si [....] » Read More
What if dementia prevention were approached as a shared public health opportunity shaped by everyday lifestyle choices, social environments, and supportive systems Growing evidence on modifiable risk factors across the life course shows that interventions targeting exercise, stre [....] » Read More
Global ageing demands a transition from reactive disease management to predictive, data-driven preventive care. Advances in imaging technology and artificial intelligence now enable quantification of longevity biomarkers that extend beyond traditional diagnostics.Whole-body MRI-d [....] » Read More
The human lifespan and quality of life depend on complex interactions among genetic, environmental, and lifestyle factors. In this context, a new systems approach to ageing people, diseased states and wellness result in a new branch in the healthcare services, namely, personalize [....] » Read More
Atherosclerosis is accompanied with inflammation, affecting the vascular endothelial transport. The mechanisms of mast cells (MSc) secretome influence on transendothelial transport is unclear. The aim was to study the effect of MCs-derived biological factors on the transendotheli [....] » Read More
Cellular senescence, a hallmark of aging, is closely linked to chronic inflammation and dysregulation of innate immune responses through the Senescence-Associated Secretory Phenotype (SASP). The Yamanaka factors (OSKM) can rejuvenate aged cells but pose oncogenic risks, primarily [....] » Read More
As digital technologies become increasingly integrated into daily life, social media use has expanded across all age groups, including older adults. While social media platforms can facilitate social connection, information sharing, and engagement, excessive and compulsive use ma [....] » Read More
The contemporary understanding of pain has evolved from a biomedical model focused on tissue damage to more integrative perspectives, supported by advances in neuroscience and behavioral science. Various studies demonstrate that pain is a multifactorial experience modulated by ne [....] » Read More
Background: China faces an unprecedented aging challenge with fragmented care delivery and lack of standardized geriatric assessment protocols. While WHO launched the Integrated Care for Older People (ICOPE) framework in 2017, its adaptation to China's hospital-based healthc [....] » Read More
Background: Frailty is highly prevalent among older gastric cancer patients and strongly associated with adverse postoperative outcomes. While frailty interventions have been implemented, few have focused on family cohesion as a pivotal aspect. This study aims to evaluate the eff [....] » Read More
The Rohingya people have been subjected to egregious human rights abuses, culminating in a mass exodus to the Cox's Bazar district of Bangladesh in 2017. This study investigated the knowledge, attitudes, and practices surrounding older persons within the Rohingya refugee comm [....] » Read More
Background: Aging is driven by interconnected hallmarks including telomere attrition, mitochondrial dysfunction, cellular senescence, and chronic low-grade inflammation that collectively reduce tissue resilience and regenerative capacity. Metformin, mitochondrial-support su [....] » Read More
Biology is no longer destiny. Our DNA doesn’t determine our health and disease prospects, as geneticists once believed. According to the new science of epigenetics, the vast majority of our genes are fluid and dynamic and their expression is shaped by what we think and what [....] » Read More
The mechanisms governing lifespan evolution across organisms have long remained elusive. Integrative analyses of multiple large-scale datasets across the animal kingdom now reveal that noncoding RNAs (ncRNAs), rather than proteins, serve as the principal drivers of lifespan evolu [....] » Read More
As the global cancer burden rises, adults with advanced cancer face significant physical and psychosocial symptoms requiring early integration of palliative and supportive care. Nurses in oncology, emergency, and community settings are central to symptom assessment, care coordina [....] » Read More
For meeting the financial, quality and safety challenges as well as expectations of the patients, health and social care systems around the globe currently undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), supported by [....] » Read More
Tumor growth is a highly complex biological event that involves not only malignant cells’ proliferation but also a huge proliferation movement of supportive tissues that allow tumor growth. Included in these supportive elements, blood vessels may grow in differential patter [....] » Read More
Human body is a home for trillions and trillions of tiny organisms - microbes/ bugs (bacteria, archaea, fungi, protozoa, viruses), collectively termed as the indigenous flora/microbiome of the body. A diverse microbiota is associated with every human being from shortly after birt [....] » Read More
Direct myocardial transplant of HFDSCs (human fetal derived stem cells) by open chest surgical procedure was performed in 10 patients with Heart Failure (HF) due to no ischemic, no chagasic dilated cardiomyopathy. All 10 patients survived the operation. At 40 months, the mean (&p [....] » Read More
Longevity has become a financially lucrative, enduring topic ever since thefirst signs of a decline in human life expectancy, the diminishing faith in nature’s self-healing powers, and the outbreak of wars that threaten everything. There are several methods that are unlike [....] » Read More
Background: As global populations age, the reliance on pharmacological solutions for mental health specifically for stress and sleep disorders has reached critical levels. Often, these clinical approaches overlook the systemic inequities, such as gender and socioeconomic barriers [....] » Read More
Description: The working environment is constantly changing with the aging population increasing. Due to the changes in the working pattern, new emerging risks have been introduced with many challenges to be managed. Nowadays, Occupational Safety and Health (OSH) management shoul [....] » Read More
Background: Immunotherapy has transformed cancer management. Patients receiving immune checkpoint inhibitors frequently experience concurrent pain and sleep disturbances that affect quality of life, treatment adherence, and overall survival. Nursing interventions addressing both [....] » Read More
Pneumonia is a serious complication after hip fracture surgery and the leading risk factor for 30-day mortality in this vulnerable population. Identifying modifiable perioperative factors may help improve outcomes in fragile elderly patients aged 80 years or older. We retrospecti [....] » Read More
Population ageing has led to an increasing number of older adults requiring long-term care in institutional settings, which entails a higher risk of elder abuse. Elder abuse, understood as actions or omissions that violate older adults’ dignity, rights, and well-being, rema [....] » Read More
Ageing of the population has become one of the leading health problems for the 21st century, especially in developing countries, where the health care systems are already stretched thin. Medical advances, improved hygiene conditions, adequate nutrition, and increased accessibilit [....] » Read More
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Alchemy, one of the most venerable of spiritual technologies, with origins shrouded in mystery, represents a transformative journey of the soul; the alchemist strives, through the arcane processes of the opus, to achieve a state of purification, perfection, and ultimately an elev [....] » Read More
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Advances in primary cardiovascular prevention depend upon enhanced risk stratification. Gated coronary artery calcium CT scanning independently identifies persons at increased risk for major acute cardiac events including sudden death due to subclinical coronary atherosclerosis. [....] » Read More
Title : Ace-dependent Alzheimer’s disease (AD)
Sergei M Danilov, University of Illinois at Chicago, United States
An analysis of 1200+ existing missense ACE mutations revealed that >400 are predicted to be damaging and led us to hypothesize that heterozygous carriers of these loss-of-function (LoF) ACE mutations (which result in low ACE levels-less than 50% of mean in population) may be a [....] » Read More
Title : The science of longevity delivery: Why capability, not biology, determines outcomes
Jason Beckwith, BioTalent, United Kingdom
The field of longevity science is advancing rapidly, driven by breakthroughs in genomics, cellular reprogramming, AI-enabled drug discovery, and personalised medicine. However, a persistent gap remains between biological innovation and real-world outcomes. This paper argues that [....] » Read More
Title : Resonance & recovery: How frequency modalities restore biological rhythm
Dmitri Leonov, University of California Berkeley, United States
Current medical paradigms largely operate on a Newtonian model, treating the human body as a sophisticated 3-D machine governed by chemical reactions and mechanical functions. While this approach has been instrumental in acute care, it often overlooks the fundamental reality esta [....] » Read More
Title : Association between patient characteristics and low-dose naltrexone use among palliative care patients: A retrospective analysis using Epic Cosmos (2022–2024)
Utpol Das, University of Texas Medical Branch at Galveston, United States
Background: Low-dose naltrexone (LDN) is increasingly prescribed for chronic pain and inflammatory conditions, yet utilization patterns among palliative care populations remain poorly characterized. Older adults receiving palliative care represent a clinically distinct group in w [....] » Read More
Title : The mindset framework: A transformational approach to building resilience, confidence and sustainable success
Tiffany R Harris, Shift Your Mindset & Dream BIG LLC, United States
This presentation introduces the mindset Framework, a transformative approach designed to help individuals build resilience, overcome limiting beliefs, and achieve sustainable success. In today’s fast-paced and demanding environments, mindset plays a critical role in perfor [....] » Read More
Title : Aging and its impact on fiscal health - A comparative analysis of the USA and South Korea
Giacomo DiPasquale, Wagner College, United States
Population aging is reshaping the fiscal and labor market structures of advanced economies. This paper compares the United States and South Korea two countries with distinct demographic histories but converging aging profiles over the period 2000–2022. Using annual macroeco [....] » Read More
Title : Expected lifespan and healthspan among rural and urban individuals in Java, Indonesia
Siti Masfiah, Vrije Universiteit Amsterdam, Netherlands
In Indonesia, adults living in rural areas have a longer life expectancy than their urban counterparts. Beyond observed longevity, attention has focused on lifespan and healthspan expectations as predictors of health outcomes. This study examines expected lifespan and expected he [....] » Read More
Title : The latest advances on biological rejuvenation
Jose Cordeiro Mateo, International Longevity Summit, Spain
For most of human history, aging has been viewed as an inevitable and irreversible process. However, remarkable scientific advances over the last two decades have transformed aging from an unavoidable fate into a potentially modifiable biological condition. The emerging field of [....] » Read More
Title : A new perspective on aging: Creativity, empowerment and sustainability
Joana de Vilhena Novaes, Universidade Veiga de Almeida/UVA, Brazil
Population aging constitutes one of the most significant social phenomena of the twenty-first century, requiring a revision of traditional paradigms that associate old age with decline, unproductivity, and dependence. A new perspective on aging proposes shifting this deficit-orie [....] » Read More
Title : THP-1 cells as an in vitro platform for modeling macrophage senescence-like phenotype and primary screening of senolytic and anti-atherogenic compounds
Yelizaveta Marakhovskaya, Institute on Aging Research, Russian Federation
Atherosclerosis is increasingly understood not merely as a disorder of lipid accumulation, but as an age-associated chronic inflammatory disease in which monocytes, macrophages, and foam cells play a central pathogenic role. Within this framework, cellular senescence and immune a [....] » Read More
Title : Changes in well-being, energy levels, and perceived healthy aging following participation in a longevity wellness IV program among Filipino adults: A prospective pilot study
Arianne Velarde, Drip Options Wellness Clinic, Philippines
Healthy aging has emerged as a major public health priority as populations continue to age worldwide. Alongside this trend, wellness-oriented intravenous (IV) therapies have gained popularity in preventive health settings despite limited evidence regarding their effects on patien [....] » Read More
Title : Hydrogen medicine: A new way to rejuvenation and longevity
Ashot Khachatryan, National Academy of Sciences of the Republic of Armenia, Armenia
Modern humans often live only half of their biologically allotted lifespan, spending much of their time battling age-related ailments. Aging is driven by oxidative stress every second, our cells are attacked by over one hundred thousand free radicals that strip electrons, reduce [....] » Read More
Title : mRNA platform-based klotho therapy for hepatic injury
Jaegoo Yoon, The Catholic University of Korea, Korea, Republic of
Hepatocyte senescence triggers metabolic aberrations that drive the progression of hepatic injury. A critical pathological hallmark of hepatic injury progression is liver fibrosis, characterized by excessive extracellular matrix deposition, which is closely linked to the intracel [....] » Read More
Title : Delivery of NRF2 via mRNA-LNP platform to inhibit the progression of pulmonary fibrosis
Junho Kim, The Catholic University of Korea, Korea, Republic of
A key pathological driver is the excessive accumulation of Reactive Oxygen Species (ROS) within the alveolar microenvironment. This oxidative stress triggers the differentiation of fibroblasts into myofibroblasts, resulting in aberrant Extracellular Matrix (ECM) deposition and th [....] » Read More