Tahoe Therapeutics (@tahoe

Tahoe Therapeutics

236 posts

Tahoe Therapeutics

@tahoe_ai

Mapping how chemistry perturbs biology to build a virtual model of the human cell. Formerly known as Vevo Therapeutics.

South San Francisco, CA

Joined November 2022

Pinned
Tahoe Therapeutics
@tahoe_ai
Jun 9
We went back to basics to model cell states. Introducing our Rhaister model + Emerald Bay dataset. See link in comments.
Nima Alidoust
@nalidoust
Jun 9
Today we release Rhaister, an elegant statistical model that predicts drug phenotypes in new contexts w/ accuracies comparable to experimental assays. And dropping Emerald Bay, a 2M cell dataset measuring long time-course phenotypes across 1000s of drug-cell line interactions.
00:00
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Tahoe Therapeutics reposted
Johnny Yu
@iamjohnnyyu
Jun 9
Rhaister is a moment in the virtual cell space. This is a model that for the first time generates and prioritizes synthetic data. That means instead of going into the lab to generate the transcriptome, you go into the computer. Just the start of virtual cell you heard it here
Nima Alidoust
@nalidoust
Jun 9
Today we release Rhaister, an elegant statistical model that predicts drug phenotypes in new contexts w/ accuracies comparable to experimental assays. And dropping Emerald Bay, a 2M cell dataset measuring long time-course phenotypes across 1000s of drug-cell line interactions.
00:00
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Tahoe Therapeutics reposted
Hani Goodarzi
@genophoria
Jun 9
@tahoe_ai team doing what they do best! A key takeaway from VCC’25 for us was that in the current data regimes, elegant statistical models match if not surpass far more complex transformer-based architectures! “Going back to the basics” is such a great title for this… to say
Nima Alidoust
@nalidoust
Jun 9
Today we release Rhaister, an elegant statistical model that predicts drug phenotypes in new contexts w/ accuracies comparable to experimental assays. And dropping Emerald Bay, a 2M cell dataset measuring long time-course phenotypes across 1000s of drug-cell line interactions.
00:00
2.2K
Tahoe Therapeutics reposted
Nima Alidoust
@nalidoust
Jun 9
Replying to @nalidoust
A more in-depth tweetorial from @vallens
Valentine Svensson
@vallens
Jun 9
At Tahoe, one of the reasons we are excited about perturbation prediction is to ultimately predict how patient samples will respond to any of the many drugs in our library
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Tahoe Therapeutics reposted
Valentine Svensson
@vallens
Jun 9
At Tahoe, one of the reasons we are excited about perturbation prediction is to ultimately predict how patient samples will respond to any of the many drugs in our library
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Tahoe Therapeutics reposted
Shreshth Gandhi
@shreshth_gandhi
Jun 9
Replying to @nalidoust
So excited for this to be finally out! Incredible work led by @vallens . Rhaister allowed us to do launch hundreds of dataset scaling experiments in hours in what would have taken months with the previous generation of perturbation models 🚀🚀
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Tahoe Therapeutics
@tahoe_ai
Jun 9
Replying to @tahoe_ai
Read more ⤵️ Paper: tahoebio-assets.com/rhaister-manus… Model and datasets: huggingface.co/collections/ta…
261
Tahoe Therapeutics reposted
Nima Alidoust
@nalidoust
Jun 9
Today we release Rhaister, an elegant statistical model that predicts drug phenotypes in new contexts w/ accuracies comparable to experimental assays. And dropping Emerald Bay, a 2M cell dataset measuring long time-course phenotypes across 1000s of drug-cell line interactions.
00:00
44K
Tahoe Therapeutics reposted
Georgia Channing
@cgeorgiaw
Apr 29
🤗🤗🤗introducing Hugging Science -- the home of AI for science 🤗🤗🤗 open models and datasets are the powerhouse of science (see the PDB), but finding the models and data you actually need for your breakthrough is hard af you shouldn't need to scrape arxiv, own your own
00:00
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Tahoe Therapeutics reposted
Nima Alidoust
@nalidoust
Mar 18
In our new blog post, we team up with @NVIDIAHealth to make it possible to map how drug effects cascades through gene regulatory networks.
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Tahoe Therapeutics
@tahoe_ai
Mar 18
Read the full blog on our Substack:
Nima Alidoust
@nalidoust
Mar 18
In our new blog post, we team up with @NVIDIAHealth to make it possible to map how drug effects cascades through gene regulatory networks.
Mapping Drug Response Cascades with a Causal Gene Regulatory Network at 100M-Cell Scale
From blog.tahoebio.ai
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Tahoe Therapeutics
@tahoe_ai
Mar 17
Replying to @tahoe_ai
Tahoe Careers Page:
jobs.lever.co
Tahoe Therapeutics
Job openings at Tahoe Therapeutics
224
Tahoe Therapeutics
@tahoe_ai
Mar 17
It was a pleasure meeting members of the @BerkeleyML community last week! Our team always enjoys connecting with talented students who are passionate about ML x Bio 💙 We’re excited to continue these conversations and are open to speaking with prospective internship and
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