StatMate 2.0

GraphPad StatMate takes the guesswork out of evaluating how many data points you'll need for an experiment, and makes it easy for you to quickly calculate the power of an experiment to detect various hypothetical differences.

Its wizard-based format leads you through the necessary steps to determine the tradeoffs in terms of risks and costs.
There is no learning curve with StatMate because it is self-explanatory. All the documentation you need is built right into the program.