A team of researchers, led by Cassandra Callmann at The University of Texas at Austin, developed a synthesis method for glycopolymers that affords precise control over polymer length, backbone structure, and density of pendant carbohydrates. The team identified the latter to be a critical factor for lectin binding, with grafting densities below 50% resulting in weaker interactions.
The GlycoMIP User Facility provided rheological and structural information on the alginates used. The team hopes to further improve menstrual care, leading to advancements in improving the quality of life for women.
Researchers at McGill University, supported by GlycoMIP scientists at UGA, analyzed a water-soluble component of the self-healing Mistletoe Viscin adhesive after extraction. Systematic characterization of the chemical components enables direct links between adhesive performance and molecular features.
The GlycoMIP In‑House Research Team developed a machine learning–based framework to establish appropriate MSn protocols and effective data analysis methods for inferring glycosidic linkages in glycans. As a proof of principle, the approach was applied to the elucidation of sialic acid linkages using sialyllactose standards and NIST glycans.
Machine‑learning framework for glycan linkage inference (PDF)
Three mucus types in C. aspersum were characterized, including proteins, glycosylation, ion content, and mechanical properties. Advanced mass spectrometry revealed previously unreported details on both N‑ and O‑linked glycans, providing new insight into structure–function relationships. This study was reported by outlets including NPR.
Working alongside FLSI’s existing SURF program, GlycoMIP leverages a long‑standing framework for introducing undergraduate students to graduate‑level research. Participants gain professional development training, hands‑on laboratory experience, and individualized mentorship from GlycoMIP faculty and staff.
Broadening participation through the GlycoMIP SURF program (PDF)
GlycoMIP’s second annual Summer School was held June 13–17, 2022 at the Virginia Tech user facility. Twenty‑two academic and industry scientists participated in hands‑on laboratory exercises, lectures, and panel discussions focused on glycomaterial synthesis, characterization, and modeling.
The GlycoMIP User Facility supported research by Dr. Brandon Jutras at Virginia Tech, leading to a high‑impact publication in Nature Microbiology. The study revealed the glycan composition of the Borrelia burgdorferi cell wall, advancing understanding of Lyme disease detection and treatment.
The first two commercially available automated glycan synthesizers in the United States were installed at the GlycoMIP user facility in September 2021. The instruments enable systematic, automated synthesis of defined oligosaccharides using solid‑phase chemistry.
Installation of automated glycan synthesizers at GlycoMIP (PDF)
Through participation in the FLSI SURF program, GlycoMIP provides undergraduate students with an immersive research experience that includes laboratory work, professional development, and close mentorship by faculty and research scientists.
GlycoMIP hosted its first Summer School, a virtual event. The event featured 15 instructors and offered content aligned with the GlycoMIP facilities of synthesis, analysis and modeling services.
GlycoMIP 2021 Summer School (virtual) summary (PDF, opens in new tab)
As part of its outreach mission, GlycoMIP provided education about glycomaterials to high-school STEM teachers through the Teacher Enrichment Program of the Center for Excellence in Education.
Outreach to high-school STEM teachers (PDF, opens in new tab)