window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-676FF74DS0');
Zenodo

CLASSICA The future of AI assisted cancer surgery
CLASSICA Home2025-09-11T13:04:57+00:00

CLASSICA

Our overall aim is to improve cancer surgery outcomes by bringing AI into the operating theatre.

  • CLASSICA

The CLASSICA project will clinically validate the use of AI-driven imaging and decision support in real-time cancer surgery.

  • Clinical trial

Five leading cancer surgery centres across Europe will treat 500 patients. The validation studies will ensure that the CLASSICA technology and methods can be generalised across clinics and will help to optimise the AI assistance given to surgeons.

  • Collaboration

CLASSICA brings together experts in colorectal cancer, precision surgery, AI and technology, biomedical law and ethics, surgical training, and surgical guidelines.

  • Communication

Sharing what we learn is an important part of CLASSICA. Join our conversation on social media and stay in touch for all our latest news!

  • Technology

CLASSICA builds on breakthrough research in the AI analysis of fluorescence and perfusion in cancer tissues. The technology will differentiate between cancerous and non-cancerous tissues in real-time.

Project details

  • Project No. 101057321

  • EC Contribution: €5,978,716

  • Duration: 48 months

  • Start date: 1 May 2022

Recent publications

  • Arezzo, Alberto, Distefano, Giovanni, Ammirati, Carlo A., Barbiero, Michele, Morino, Mario. (March, 2026). Diagnostic accuracy of 1,000 endorectal ultrasounds before transanal endoscopic microsurgery for rectal neoplastic lesions. Zenodo. https://doi.org/10.1007/s00464-026-12694-9
  • Arezzo, Alberto, Ammirati, Carlo Alberto, Distefano, Giovanni, Barbiero, Michele, Sbuelz, Francesca, Passera, Roberto, Morino, Mario. (February, 2026). Which prognostic factors for recurrence after transanal endoscopic microsurgery for early rectal cancer?. Zenodo. https://doi.org/10.1007/s00464-026-12632-9
  • Niemiec, Emilia, Davis, Peter, Hauglid, Mathias K. (February, 2026). Will the EU AI Act help to mitigate dataset bias in medical AI?. Zenodo. https://doi.org/10.1093/jlb/lsag001
  • Arezzo, Alberto, Ammirati, Carlo Alberto, Distefano, Giovanni, Barbiero, Michele, AROLFO, SIMONE, Morino, Mario. (February, 2026). Peritoneal opening during transanal endoscopic microsurgery: can preoperative positioning assessment improve intraoperative management?. Zenodo. https://doi.org/10.1007/s00464-026-12625-8

Horizon Europe CLASSICA

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

© Copyright 2022 - 2026 Horizon Europe CLASSICA project | All Rights Reserved | Privacy Policy

Your privacy

By clicking accept, you agree to the storing of cookies on your device to enhance site functionality and analyse site usage data.
Cookie Settings Accept Settings

Tracking Cookies

We use Google Analytics to help us improve our website by collecting information on how you use this site. The cookies collect information without directly identifying you. You can read more about our use of Google Analytics on our Privacy Policy.

Third Party Embeds

Pages on this site may include embedded content (e.g. YouTube videos). Embedded content behaves in the same way as if a user had visited that site and these websites may collect data about you. To learn more please visit our Privacy Policy.

Necessary

Necessary cookies help make a website usable by enabling basic functions. The website cannot function properly without these cookies. You may disable these by changing your browser settings but this will affect how the website functions.

Our Privacy Policy

We respect your privacy. Our site uses several third-party services. Please select which cookies you would like to allow by selecting the checkboxes. To learn more or update your settings please visit our Privacy Policy. Thank you.
Go to Top