What if small molecules could allow you to alter protein localization at will?
What if they could allow you to turn on specific transcription factors?
Our new manuscript reveals bifunctional molecules to do just that. 🧵
GIF
William Gibson
1,886 posts
William Gibson
@wgibson
- TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules
00:00 - The time in which my fiancee asked me to assign guests to wedding tables: Spent hours creating an extension of the Kerning-Lin algorithm to partition a graph (guest list) into n equal sets (tables), optimizing number of edges (friendships) within sets (tables).
- I can't believe I'm saying this this year, but I think this might be bigger than RNA vaccines. DeepMind can effectively predict protein structure with the fidelity of crystallography. sciencemag.org/news/2020/11/g…
- Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber! If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out! gibsonlab.org
- FDA just posted the BioNTech/Pfizer vaccine data here. Lots of good stuff. fda.gov/media/144245/d… example: Looks like one dose may induce meaningful protection around day 10.
- It's funny that when I go to work, I have actually have less access to academic papers because the network blocks @Sci_Hub.
- Excited to announce new joint project with @LGibsonMD training a massive neural network with >1000x the number of parameters of GPT-3. Early goals: edge detection, laughing. We call her Sydney.
- Seeking patients with myxoid leiomyosarcoma featuring a PLAG1 fusion. We're forming a major foundation with the best minds including @DrSarcoma to find treatments and a cure for this rare disease, including developing in-vitro tumor models. Know someone affected? Pls reach out!
- Our work describing targeted protein relocalization and transcriptional rewiring is now out in @J_A_C_S !What if small molecules could allow you to alter protein localization at will? What if they could allow you to turn on specific transcription factors? Our new manuscript reveals bifunctional molecules to do just that. 🧵GIF
- Replying to @wgibsonBefore I lose you on this thread, here's the link. biorxiv.org/content/10.110…
- This first-in-class CCNE1 degrader from Monte Rosa is really impressive. It's a molecular glue that finds a shallow pocket on CCNE1 and displays cooperative binding to CRBN, w/ EC50 of 3 nM for the ternary complex. Highly specific CCNE1 degradation. ir.monterosatx.com/static-files/d…
- .@LaurenGibsonMD and I went down early, but our B cells are ready for us to go back to the hospital to fight.I'm a first-hand example that COVID-19, especially in healthy ppl, can present with incredibly vague and mild symptoms. Don't ignore ANY possible symptoms ---> stay home and help keep others safe!
- Replying to @drmichaellevinI'm glad the agency is prioritizing the things that matter, and helping science move faster.
