Srinivas Viswanathan (@srviswanathan) / X

Srinivas Viswanathan

1,179 posts

Srinivas Viswanathan

@srviswanathan

Physician-scientist | GU oncologist @DanaFarber @Harvardmed. Cancer genomics, functional genetics, RNA | Prostate Cancer; translocation RCC. Opinions my own.

Boston, Massachusetts

viswanathanlab.dana-farber.org

Joined December 2010

Pinned
Srinivas Viswanathan
@srviswanathan
Oct 3, 2024
Our paper on how X chromosome alterations drive sex differences in translocation renal cell carcinoma is now out in print @CellCellPress! Link to explainer thread if you missed it 👉: x.com/srviswanathan/…
Cell
@CellCellPress
Oct 3, 2024
The new issue is out 👉cell.com/cell/current Featuring how X chromosome genetics constrains somatic alterations and underlies cancer sex differences, the functional mapping of RAD51C variants in cancer and single-cell genomics identifying markers of neuronal vulnerability and
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Srinivas Viswanathan
@srviswanathan
Aug 20, 2024
Our study on sex differences in Xp11 translocation renal cell carcinoma is out @CellCellPress! We ascribe a genetic basis to the female bias in tRCC, which is driven by a translocation of the TFE3 gene on the X chromosome. w Zhang lab @DanaFarberNews bit.ly/4dtpNtP 🧵1/
GIF
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Srinivas Viswanathan
@srviswanathan
Jan 13, 2022
Humbled to be selected as a 2022 Damon Runyon-Rachleff Innovator and deeply grateful to @DamonRunyon for supporting our lab's research
Damon Runyon Cancer Research Foundation
@DamonRunyon
Jan 12, 2022
Congrats to the 2021 Damon Runyon-Rachleff Innovators! Six extraordinary researchers have received five initial grants, and four previous awardees were given “Stage 2” support. Read more about our new #braveandbold Innovators here: bit.ly/3qleTAh and below 🔽
00:00
Srinivas Viswanathan
@srviswanathan
Aug 6, 2019
Excited to officially start my lab @DanaFarber! Positions available at all levels - please contact me if interested in GU malignancies, genomics, functional genetics, or RNA binding proteins
Srinivas Viswanathan
@srviswanathan
Oct 7, 2024
Inspired choice for this year's Nobel in Medicine! Having cut my scientific teeth in miRNA/let-7 biology as a PhD student & having had the incredible fortune of having both of these amazing, inspiring, & humble scientists on my committee, this year's award feels extra special!
nature
@Nature
Oct 7, 2024
BREAKING: This year's #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun. The pair have been recognised "for the discovery of microRNA and its role in post-transcriptional gene regulation." Stay tuned for more from @Nature
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Srinivas Viswanathan
@srviswanathan
Feb 22, 2022
Happy that, on this numerically special Tuesday (2/22/22!), our work with @thechoilab on PRMT1 as a vulnerability in prostate cancer is published in @CellReports: cell.com/cell-reports/f… #prostatecancer #pcsm @CaP_Pubs A 🧵 (-2/7)
Srinivas Viswanathan
@srviswanathan
Aug 21, 2022
Thrilled to receive a V Scholar Award for work on molecular profiling of translocation renal cell carcinoma. Grateful for amazing lab members & for support from @TheVFoundation that will enable more progress in this #rarecancer. #VictoryOverCancer #CancerResearch @DanaFarber_GU
Srinivas Viswanathan
@srviswanathan
Feb 16, 2024
Very grateful to @DamonRunyon for continued support of our lab's work on X-chromosome alterations and sex bias in cancer.
Dana-Farber News
@DanaFarberNews
Feb 16, 2024
Congrats Srinivas Viswanathan, MD, PhD (@srviswanathan), a 2024 @DamonRunyon-Rachleff Innovation Award recipient for research into sex bias in cancer: X marks the spot: exploring how X-chromosome alterations drive sex differences in cancer. Read more: shorturl.at/orswO
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Srinivas Viswanathan
@srviswanathan
Sep 15, 2022
Extremely grateful for this support from @KidneyCancer in our efforts to make progress against this aggressive subtype of kidney cancer! #translocationRCC
Kidney Cancer
@KidneyCancer
Sep 15, 2022
Replying to @KidneyCancer
⭐️Congratulations to KCA Trailblazer Award winner @srviswanathan @DanaFarber @DanaFarberNews! He will look into advancing a cell surface therapeutic target in translocation #RCC. #kidneycancer kidneycancer.org/2022-grants/
Srinivas Viswanathan
@srviswanathan
Aug 7, 2023
Happy to share our latest collaborative preprint with CZ Zhang lab. We studied Xp11 translocation renal cell carcinoma (tRCC) – a rare kidney cancer – as a window into understanding how chrX alterations may drive sex differences in cancer. Thread 👇 1/ biorxiv.org/content/10.110…
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Srinivas Viswanathan
@srviswanathan
Jan 4, 2022
Happy to share our work on the genomic landscape of translocation kidney cancer, now out in @CellReports. A great collaboration with @drchoueiri @vanallenlab. Please see Tweetorial below by @ziadbakouny for details of the study 0/3
Ziad Bakouny, MD, MSc
@ZiadBakouny
Jan 4, 2022
Ecstatic to see our work on tRCC now published in @CellReports! Incredibly thankful to my mentors @srviswanathan, @DrChoueiri, @VanAllenLab & all co-authors @BrighamResearch @DanaFarberNews @broadinstitute @harvardmed Link: cell.com/cell-reports/f… pic.x.com/L29Ehq4veG
Srinivas Viswanathan
@srviswanathan
Nov 9, 2022
Happy to share our latest work on XIST activation in male cancers in @CellSystemsCP, a result of a great collaboration with CZ Zhang lab @HarvardDBMI and led by the supremely talented @Sadagopan_A. sciencedirect.com/science/articl… 🧵below @DanaFarber_GU @DanaFarberNews 1/12
Srinivas Viswanathan
@srviswanathan
Jun 18, 2020
Excited to share the first preprint from the @srviswanathan @thechoilab labs. Via a genome-scale CRISPR screen, we identified protein arginine methyltransferase 1 (PRMT1) as a vulnerability in CRPC likely through its ability to modulate AR signaling biorxiv.org/content/10.110… (1/4)
biorxiv.org
Genome-scale genetic screening identifies PRMT1 as a critical vulnerability in castration-resistant...
Androgen receptor (AR) signaling is the central driver of prostate cancer growth and progression across disease states, including in most cases of castration-resistant prostate cancer (CRPC). While...
Srinivas Viswanathan
@srviswanathan
Aug 19, 2023
Great time at our lab picnic today & hard to believe it has already been 4 yrs since the lab started. A privilege to work with such passionate and talented scientists every day!
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