Sek Kathiresan MD
25K posts
Sek Kathiresan MD
@skathire
SVP @EliLillyandCo; CEO @VerveTx; We are developing one-time treatments to lower cholesterol lifelong and prevent or treat heart attack
- Best guide on writing a scientific paper (ever?). journals.plos.org/ploscompbiol/a… Useful to read before each attempt to write.
- Astounding fact I learned today: Weight of average adult US male 1960: 166 pounds 2002: 191 pounds 😬
- As a cardiology consultant in the hospital, here’s my nomination for the heroes of the pandemic: 1. Nurses in the ER 2. Nurses in the ICU 3. Nurses on the floor 4. Nurses in the dialysis clinic 5. Nurses in the...
- Born in Tirupattur, India Immigrated to Pittsburgh, PA 1980 Professor Medicine @harvardmed CEO @VerveTx AssimilatedMost third-world migrants can not assimilate into civil societies. Prove me wrong.
- Proof-of-concept for an entire new way to treat heart attack: a gene editing medicine, administered once in life, safely turn off a gene --> permanently lower cholesterol or triglycerides A ‘Cure for Heart Disease’? A Single Shot Succeeds in Monkeys
- Amazing. Once weekly injection, 30lbs average weight loss Phenomenal results for a medicine to treat obesity Once-Weekly Semaglutide in Adults with Overweight or Obesity | NEJM nejm.org/doi/full/10.10…
- Can we precisely rewrite the genetic code - make a single DNA spelling change - in the liver of a human being for clinical effect? YES! Scientific milestone: VERVE-101 provides first proof-of-concept for in vivo DNA base editing in humans Clinical implication: It’s early
- Wow, say it with me: “a functional cure” for sickle cell disease with CRISPR gene editing All 31 patients with severe SCD, no vaso-occlusive crises (f/u 2 to 32 mos) Similar durability and efficacy for beta-thal 👏🏽👏🏽👏🏽 @CRISPRTX @VertexPharma crisprtx.gcs-web.com/news-releases/…
- Does chronic disease need to equal chronic care? No 👇in @Nature from @VerveTx One-time base editing Rx (in vivo liver), durable⬇️LDL-C In monkeys: *⬇️90% PCSK9,⬇️60% LDL-C, now out to 10 mos * VERVE-101: efficacy at LNP doses as low as 0.5 mg/kg nature.com/articles/s4158…
- Met with postdoc keen on staying in academia & applying for faculty jobs I asked: "Have you put together a Description of Research Activities?" 👇🏽mine from April 2007 as I was just finishing my research training & applying for research faculty positions Some thoughts...thread.
- Wow, some good news from 2016. The development of a vaccine with 100% efficacy against Ebola. thelancet.com/journals/lance…
- From Viramathi, Tamilnadu, India to Espe Elementary School @CityPGH ('80) to 👇 What a thrilling ride in this amazing country 🇺🇸 Grateful to my family.
