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Shalek Lab
@shaleklab
Alex K. Shalek Lab @MIT/@ragoninstitute/@broadinstitute/@harvardmed/@MGH_RI. Genomics, immunology, systems biology.
Cambridge, MA
shaleklab.com
Joined November 2019
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  • user avatar
    Shalek Lab
    @shaleklab
    May 4, 2021
    It’s official. I’ve been awarded tenure at @MIT @ChemistryMIT @MIT_IMES. This honor really belongs to the lab, not just me. I’m humbled and proud to be a small part of it. When I started 7 years ago, I couldn’t have imagined how awesome a ride this would be, how amazing each...
  • user avatar
    Shalek Lab
    @shaleklab
    Feb 13, 2023
    Excited and humbled to announce that I’ve been promoted to full professor at @MIT @ChemistryMIT @MIT_IMES @kochinstitute.
    72K
  • user avatar
    Shalek Lab
    @shaleklab
    Mar 14, 2020
    1/7 In light of the spread of SARS-CoV-2, we are sharing published and unpublished scRNA-seq datasets across both health and disease that harbor cells expressing ACE2 and TMPRSS2, which are critical for SARS-CoV-2 entry into host cells.
  • user avatar
    Shalek Lab
    @shaleklab
    Dec 9, 2021
    [1/n] Our new manuscript is out today in @CellCellPress! Read the details here!
    Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
    From cell.com
  • user avatar
    Shalek Lab
    @shaleklab
    Apr 21, 2020
    1/9 Update: our manuscript describing ACE2 as an interferon-stimulated gene has now been accepted at @CellCellPress. The pre-proof can be found here: cell.com/pb-assets/prod…
  • user avatar
    Shalek Lab
    @shaleklab
    Aug 17, 2021
    Spatial omics tech dev, out today! We call it SPACECAT: Spatially PhotoActivatable Color Encoded Cell Address Tags. Fluorescently tag cells by location/feature, then track, isolate, and/or profile with your favorite assay that starts from live cells nature.com/articles/s4146…
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    Shalek Lab
    @shaleklab
    Jul 25, 2024
    I am thrilled to announce that I have been appointed the new Director of the Institute for Medical Engineering and Science (IMES) at MIT, effective August 1. I would like to express my sincere gratitude and thanks to Elazer for his incredible leadership over the past 6+ years.
    32K
  • user avatar
    Shalek Lab
    @shaleklab
    Apr 5, 2020
    We’re releasing 3 more datasets related to tissues targeted by SARS-CoV-2 on our @broadinstitute single-cell data portal, the Alexandria Project: singlecell.broadinstitute.org/single_cell?sc… 1/6
  • user avatar
    Shalek Lab
    @shaleklab
    Oct 7, 2024
    🚀 Excited to share our new publication in @NatureBiotech! We explore scalable strategies for phenotypic screening using innovative methods with to address the challenges when the number of candidates is simply too large. Check out the details tinyurl.com/5f8vjhpp! (1/10)
    27K
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    Shalek Lab
    @shaleklab
    Apr 23, 2020
    Congratulations Alex!
    user avatar
    MIT Chemistry
    @ChemistryMIT
    Apr 23, 2020
    Congratulations to Professor Alex Shalek, who has been named the winner of this year's @MIT Edgerton Faculty Award in recognition of his leadership and pioneering spirit. @shaleklab @ScienceMIT chemistry.mit.edu/chemistry-news…
  • user avatar
    Shalek Lab
    @shaleklab
    Mar 21, 2022
    1/10 Our new paper is out today in @natBME! Read the details here!
    Content cover image
    Screening for modulators of the cellular composition of gut epithelia via organoid models of...
    From nature.com
  • user avatar
    Shalek Lab
    @shaleklab
    Feb 3, 2020
    Our review on inflammatory memory in barrier tissues with @ordovas_phd now out in @NatRevImmunol! nature.com/articles/s4157…
  • user avatar
    Shalek Lab
    @shaleklab
    Feb 22, 2021
    We are sharing our most recent study on the impact of SARS-CoV-2 infection on the human upper respiratory tract. In this work, we identify defects in anti-viral responses in nasal epithelial cells from individuals who develop severe COVID-19: biorxiv.org/content/10.110… (1/n)
    biorxiv.org
    Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
    Infection with SARS-CoV-2, the virus that causes COVID-19, can lead to severe lower respiratory illness including pneumonia and acute respiratory distress syndrome, which can result in profound...
  • user avatar
    Shalek Lab
    @shaleklab
    Apr 29, 2021
    1/17: Two studies in @nature on single-cell profiling of lung tissues in patients with lethal COVID-19. Amazing coordination & collaborations on many fronts. @ColumbiaMed study: nature.com/articles/s4158… Our @broadinstitute study: nature.com/articles/s4158… Graphic @GraphicAnja