Omega-3 supplements slow biological ageing
Prof Steve Horvath
432 posts
Prof Steve Horvath
@prof_horvath
Joined May 2022
- Genuine epigenetic rejuvenation in primary cells has long been the holy grail. A groundbreaking preprint reveals that over-expression of a single (secret) gene overcomes this barrier: greatly reduced age estimates across in fibroblasts and keratinocytes according to validated
- Axolotls seem to hit a pause on aging after age 4, as revealed by epigenetic clocks. 🕰️🦎✨ Yuliia Haluza, Joseph Zoller, Max Yun (2024) Axolotl epigenetic clocks offer insights into the nature of negligible senescence biorxiv.org/content/10.110…
GIF - Rejuvenation of memory and DNA methylation in the hippocampus of 2 year old rats via Yamanaka factor adenovirus gene therapy. 🧬🧠 #GeneTherapy #Neuroscience #Aging Rudy Goya (2024) Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy. GeroScience.
- Curious about the mechanisms driving #EpigeneticClocks? 🕰️ Hormones play a role! Higher testosterone/estradiol ratio links to a younger #EpigeneticAge in men according to second generation clocks. 🧬 Dive into the details here: link.springer.com/article/10.100… #Epigenetics #AgeingResearch
GIF - 🧬Maximum mammalian lifespan is inversely related to rate of change in methylation at specific DNA regions (bivalent regulatory regions): ROC= 1/maximum lifespan. Several beautiful equations link age-related methylation changes to maximum lifespan. Methylation data bring a dream
- Disappointing results continue to accumulate in longevity research regarding efforts to remove or replace aged blood plasma in humans. The removal of old plasma (via plasmapheresis) was thought to eliminate pro-aging factors. In Borsky et al. (2025), healthy middle aged adults
Like an oil change for your blood: therapeutic plasma exchange (TPE) replaces old plasma with healthy fluid. Epigenetic clock analysis of a randomized controlled trial (N=42, adults 50+) found biweekly TPE with intravenous immunoglobulin (IVIG) most effective. Surprisingly, by - Pan-mammalian epigenetic clocks are highly accurate across species, from mice to whales! 🐭🐋These clocks predict mortality risk, hinting at their value in preclinical studies. Epigenetic aging processes are evolutionarily conserved across mammals, intertwining aging and
- 🚨 Breakthrough in Epigenetic Clocks.The "Androgen Clock" offers deep insights into how hormonal regulation shapes DNA methylation. This fully controllable clock only "ticks" when both androgen receptors and androgens are present. • Powered by a single, highly predictive
- Axolotls stop aging after four years—could studying them help humans live longer? nationalgeographic.com/science/articl… via @NatGeo
- Part 1 of the trilogy on mammalian lifespan. 1️⃣ Rate of methylation change in bivalent promoters=1/Lifespan. 2️⃣ Young animals' rate is proportional to that of old animals linking aging to development. #EvolutionaryBiology #Aging #Epigenetics #Longevity
- Transplanting young Hematopoietic Stem Cells (or CD150 low) into old mice rejuvenates their blood's epigenetic age and boosts physical performance, 🩸 Improved muscle strength and even cognitive function. Yuting Wang, Yi Zhang (2025): Reducing functionally defective old HSCs
- Youthful blood induces systemic rejuvenation in older mice. Long-term heterochronic parabiosis lowers epigenetic age by up to 30% and enhancing both life span and health span. The epigenetic rejuvenation effect was maintained even two months after disconnection. Universal pan
- Nature Review: Unlocking computational frontiers in epigenetic clocks. How will next-gen of epigenetic clocks unlock breakthroughs in cell rejuvenation? How will single-cell DNAm data reveal deeper insights? Andrew E. Teschendorff (2025) Epigenetic ageing clocks: statistical
GIF
