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Lydia Finley
@lydfinley
Cell biologist with an interest in pretty much everything
ski.edu/finley
Joined March 2017
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  • user avatar
    Lydia Finley
    @lydfinley
    Mar 9, 2022
    Our new work describing a “non-canonical” TCA cycle that is engaged in a cell-state dependent manner is out today in @Nature nature.com/articles/s4158…. Congratulations to lead authors @paigearnold2 @__btjackson @GSKGradSchool @MSKCancerCenter. A few highlights:
    Content cover image
    A non-canonical tricarboxylic acid cycle underlies cellular identity
    From nature.com
  • user avatar
    Lydia Finley
    @lydfinley
    Dec 26, 2022
    Do you ❤️ the TCA cycle? (trick question). Our new review discusses the origins, discovery, and many functions of the mammalian TCA cycle. By @paigearnold2 @SKI_CellBiology out now in @jbiolchem jbc.org/article/S0021-…
    139K
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    Lydia Finley
    @lydfinley
    Jun 22, 2022
    Pretty wild: cancer cells more likely to spread during sleep (!) nature.com/articles/s4158… Interesting and dramatic example of how physiology intersects with fundamental cell biology-- here, circadian hormone rhythms and intravasation
    Content cover image
    The metastatic spread of breast cancer accelerates during sleep
    From nature.com
  • user avatar
    Lydia Finley
    @lydfinley
    Feb 12, 2025
    Things I wish more people knew about doing science in the US (thread):
    102K
  • user avatar
    Lydia Finley
    @lydfinley
    Feb 28, 2023
    What is cancer metabolism? My ❤️letter to the field surveys how metabolic networks support cell functions, key papers in the field, and a call to study normal cell metabolism, too @CellCellPress @MSKCancerCenter
    What is cancer metabolism?
    From cell.com
    104K
  • user avatar
    Lydia Finley
    @lydfinley
    Mar 9, 2022
    Back by popular demand: our follow-the emoji TCA cycle, v2.0
  • user avatar
    Lydia Finley
    @lydfinley
    Sep 18, 2019
    Our work identifying alpha-ketoglutarate as an effector of p53-mediated tumor suppression, the result of a fantastic collaboration with Scott Lowe’s lab @SloanKettering, is out today in @Nature! nature.com/articles/s4158… /n
  • user avatar
    Lydia Finley
    @lydfinley
    Oct 9, 2019
    This is my opus.
  • user avatar
    Lydia Finley
    @lydfinley
    May 25, 2020
    Our latest work @sloan_kettering, which illustrates how the metabolic profile of stem cells dictates their ability to form a neoplasm, is out today in @naturecellbio! nature.com/articles/s4155… 1/n
    Content cover image
    Extracellular serine controls epidermal stem cell fate and tumour initiation
    From nature.com
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    Lydia Finley
    @lydfinley
    May 18, 2022
    Why do only a subset of cancer cells metastasize? Happy to highlight in @NatureNV with @s__baksh beautiful new work from @fendtlab showing how heterogeneous PHGDH expression in cancer cells underlies variable propensity for metastasis: nature.com/articles/d4158…
  • user avatar
    Lydia Finley
    @lydfinley
    Feb 1, 2022
    How do cells cope with transient disruption in nutrient supply? Work from the Overholtzer lab shows lysosomes store amino acids, helping sustain protein synthesis during starvation. So much to learn about how nutrients are trafficked through the cell!
    pnas.org
    Leucine retention in lysosomes is regulated by starvation | PNAS
    Cells acquire essential nutrients from the environment and utilize adaptive mechanisms to survive when nutrients are scarce. How nutrients are traf...
  • user avatar
    Lydia Finley
    @lydfinley
    Apr 28, 2025
    Our latest work, led by @__btjackson and Angela Montero @MSKCancerCenter demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells
    23K
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    Lydia Finley
    @lydfinley
    Feb 23, 2023
    Come join us tomorrow for an amazing day of science @MSKCancerCenter celebrating Craig Thompson and his continually pioneering work that got us all to ❤️ metabolism. For the alums: what paper made you join his lab? For me...
    67K
  • user avatar
    Lydia Finley
    @lydfinley
    Nov 17, 2022
    Hi twitter! We are excited to share our very first preprint! Led by Pavlina Todorova, we show that it’s not just what nutrients you use, but how you get them, that has implications for cell fate control. Thread!
    biorxiv.org
    Amino acid intake strategies define pluripotent cell states
    Mammalian pre-implantation development is associated with striking metabolic robustness, as embryos can develop in a wide variety of nutrient conditions including even the complete absence of soluble...