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Jay Shendure
@JShendure
Genomics technology developer. Developmental biology adult learner. Professor at @uwgenome @HHMINEWS @BrotmanBaty. He/him.
Seattle, WA
krishna.gs.washington.edu
Joined May 2011
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    Jay Shendure
    @JShendure
    Nov 5, 2021
    Today we release in @biorxivpreprint a pair of related methods, DNA Ticker Tape & ENGRAM, for multiplex, temporally ordered genomic recording of cell lineage histories, enhancer & signal transduction activities, respectively led by the brilliant @_Choi_Junhong & @wchenomics 1/25
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    Jay Shendure
    @JShendure
    Apr 6, 2023
    Excited to share our lab's latest preprint, led by @CXchengxiangQIU, @bethkarenmartin & Ian Welsh of @jacksonlab. We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup. Preprint: tinyurl.com/2nhe4mm9 1/n
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    Jay Shendure
    @JShendure
    Feb 14, 2024
    Our latest out today in @Nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. OA PDF: rdcu.be/dyDAg
    user avatar
    Jay Shendure
    @JShendure
    Apr 6, 2023
    Excited to share our lab's latest preprint, led by @CXchengxiangQIU, @bethkarenmartin & Ian Welsh of @jacksonlab. We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup. Preprint: tinyurl.com/2nhe4mm9 1/n
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    90K
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    Jay Shendure
    @JShendure
    Oct 19, 2022
    Fantastically optimized and detailed single cell-RNA-seq protocol (variant of sci-RNA-seq3) developed by @bethkarenmartin, out in @NatureProtocols today, less than 1 cent per cell. tinyurl.com/34a9e8tp
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    Jay Shendure
    @JShendure
    Jun 10, 2021
    Our latest preprint, from the brilliant @CXchengxiangQIU, systematically integrates a series of single cell RNA-seq datasets that collectively span mouse gastrulation and organogenesis (E3.5 – E13.5) (1/4)
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    Jay Shendure
    @JShendure
    Dec 30, 2021
    In memory of Debbie Nickerson, a pioneer in human genomics and a dear mentor, colleague and friend. 💔 newsroom.uw.edu/news/memoriam-…
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    Jay Shendure
    @JShendure
    Apr 3, 2023
    This is a brilliant idea and proof-of-concept from @NadavAhituv lab. "Browning" the fat in the vicinity of a tumor (via CRISPRa) suppresses cancer progression as the brown fat competes with the tumor for nutrients. Preprint: tinyurl.com/m4d5ccbs
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    Nadav Ahituv
    @NadavAhituv
    Mar 29, 2023
    Tumors need a lot of nutrients to grow. By engineering and implanting fat cells to outcompete cancers for nutrients we can suppress them. Novel cancer therapy called Adipose Manipulation Transplantation (AMT). AMAZING work by Hai Nguyen and others! biorxiv.org/content/10.110…
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    Jay Shendure
    @JShendure
    Oct 21, 2022
    Our lab's latest protocol, more brilliant work from @bethkarenmartin & @CXchengxiangQIU We can't send to @biorxivpreprint b/c they desk-reject all protocols ;) Onwards to @eLife where I predict @mbeisen's assessment will be "delicious" Non-paywalled PDF: tinyurl.com/3zsyabpp
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    Jay Shendure
    @JShendure
    Apr 30, 2021
    Very proud of Waddington's Waterslide, drawn by my 13 y/o daughter (for $5) as the original sketch for a @NatureNV with @CXchengxiangQIU on a terrific new paper from the Steltzer and Tanay groups at @WeizmannScience. go.nature.com/3eM8C9J
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    Jay Shendure
    @JShendure
    Jun 10, 2021
    Congratulations to Dr. @SRsrivatsan on a brilliant (and successful) thesis defense!! (@coletrapnell @uwgenome @UW_MSTP)
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    Jay Shendure
    @JShendure
    Oct 14, 2021
    Happy to be a part of what is apparently Prime Editing day :). Our latest, PRIME-DEL, conceived and reduced to practice by @_Choi_Junhong and @wchenomics, leverages paired prime editing guide RNAs to essentially 'program' precise genomic deletions. 1/4 nature.com/articles/s4158…
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    Jay Shendure
    @JShendure
    Mar 16, 2023
    Our latest! Philosophical and practical arguments for a tree-based nomenclature for defining, naming, and organizing cell types (a "consensus ontogeny"), from Silvia Domcke (@sdomcke) and me. authors.elsevier.com/a/1glnfL7PXmbl-
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    Jay Shendure
    @JShendure
    May 10, 2024
    Finally out in @naturemethods from the brilliant @jb_lalanne & @SRegalad0, our highly quantitive single cell MPRA (scQer), applied to mammalian embryoids to find autonomous enhancers. Bonus = Tornado circular barcodes that are all kinds of useful. OA link: rdcu.be/dHqo1
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    Jay Shendure
    @JShendure
    Mar 15, 2022
    Short thread on our latest work, from the incredible @CXchengxiangQIU (CX Qiu), entitled "Systematic reconstruction of cellular trajectories across mouse embryogenesis", which is out today in @NatureGenet. Link to accessible version: 1/n rdcu.be/cIWq2