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John Chodera (he/him)
@jchodera
Changing drug discovery one ratio of partition functions at a time. Heading up antiviral discovery for pandemics: asapdiscovery.org choderalab.org/disclaimer
New York, NY
Joined July 2008
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    I have followed the rest of science Twitter to Bluesky. Join me there:
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    Here's what I spent the last few years working on. Incredibly proud of the work done by all of the amazing scientists and volunteers who contributed, and optimistic for the future of open science drug discovery for globally equitable and affordable access:
    The COVID Moonshot—an open-science, crowdsourced, and patent-free drug discovery campaign targeting the #SARSCoV2 virus—has yielded a wealth of data that could pave the way for the development of new and better therapeutics. Learn more in Science: scim.ag/4LB
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    Today is a HUGE day for the COVID Moonshot! 🌙🚀 Here's the first compound that meets our criteria for progression to preclinical studies, and the updated @bioRxiv preprint describing its discovery!
    Today we're delighted to share a significant milestone in Moonshot’s journey towards an open-science COVID antiviral: We have identified compounds meeting our criteria for progression to preclinical evaluation!
    Chemical structure of a key antiviral compound from the COVID Moonshot, showing excellent antiviral activity and enzymatic potency
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    I still can't believe you folks running @foldingathome have generated 3.6 MILLISECONDS of Mpro free energy calculation data for the @covid_moonshot in the past seven days! That's completely mind-boggling!
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    Check out the new @foldingathome blog post about the @covid_moonshot receiving $10M in funding to take a patent-free SARS-CoV-2 Mpro inhibitor all the way to IND! foldingathome.org/2021/09/27/cov…
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    Absolutely floored to receive the Summary Statement for our @covid_moonshot @NIH COVID-19 Emergency R01 and see essentially all critiques are complaints about grantsmanship and lack of publications. You can read the proposal and Summary Statement here: choderalab.org/news/covid-moo…