Isha Jain (@ishahjain) / X

Isha Jain

702 posts

Isha Jain

@ishahjain

Core Investigator @arcinstitute & Associate Professor @Gladstone @UCSF studying the mysteries of oxygen, vitamins and aging

San Francisco, CA

Joined March 2017

Pinned
Isha Jain
@ishahjain
Feb 25
A century ago, “vitamin hunters” discovered micronutrients. Today, vitamins are taken adhoc. We revisited this with modern genetics: CRISPR screens -> new NAXD disease mouse -> over 40× lifespan increase w/ vitamin B3. Huge credit to Ankur & Skyler! tinyurl.com/32k74629 🧵👇
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Isha Jain
@ishahjain
Apr 7, 2020
Beyond HIF! Our latest work identifying hundreds of genes only needed in hypoxia or normoxia - mitochondria, lipids, peroxisomes/etherlipids and more. Lots of exciting oxygen-related pathways and diseases to study for years to come! w/ @VamsiMootha cell.com/cell/fulltext/…
Isha Jain
@ishahjain
Feb 17, 2025
🚨 New paper alert! 🚨 Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with @MazeInBiotech 🔗 Paper: doi.org/10.1016/j.cell… @CellCellPress
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Isha Jain
@ishahjain
Jul 25, 2020
We are hiring! Post-docs and/or staff scientists to work on exciting projects related to oxygen and vitamins. Combination of systems biology, in vivo physiology, cell metabolism and more...Email [email protected] if interested. More details at ishajainlab.com. Please RT!
Isha Jain
@ishahjain
Jun 30, 2023
We are hiring!!! research assistant/technician and post-docs. Check out our website (ishajainlab.com) to learn more about our exciting work on oxygen and vitamin metabolism. And here are the postings: (RA/tech): rb.gy/uuebm (Post-doc): rb.gy/re211
ishajainlab.com
Home | Oxyjain Lab
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Isha Jain
@ishahjain
Mar 8, 2023
And presenting our new work where we ask -- why is oxygen toxic? bitly.ws/BjZW We dig deep into mechanism and prove a unifying model of cyclic oxygen toxicity. A true magnum opus led by @baik_alan, Galih Haribowo, @kirsten_chenx More below @MolecularCell @GladstoneInst
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Isha Jain
@ishahjain
Apr 28, 2025
🚨Preprint alert!🚨 Why do high-altitude populations have lower rates of metabolic syndrome and lower blood glucose? Superstar postdoc Yolanda tackled this❓tinyurl.com/2x7ptyn8 @GladstoneInst @arcinstitute @UCSF #hypoxia #oxygen
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Isha Jain
@ishahjain
Dec 16, 2020
So excited for the next chapter @GladstoneInst @UCSF!! Thank you to all mentors and supporters over the years - Kathy Iovine, @VamsiMootha, Warren Zapol, Erin O'Shea, @vikram0285 and many, many more. And most of all, to my amazing lab members. PS. We are still hiring, join us!!
Gladstone Institutes
@GladstoneInst
Dec 16, 2020
Welcome @ishahjain! 🎉🎊 gladstone.org/news/isha-jain…
Isha Jain
@ishahjain
Oct 16, 2024
We are so lucky to be joining the amazing @arcinstitute team!!! Excited to be a part of this new community. #Arc #Gladstone #UCSF (Ps. we are hiring at all levels!) 🎉🔬🧪
Arc Institute
@arcinstitute
Oct 16, 2024
💡Arc was founded so that brilliant minds can pursue their boldest ideas. Announcing the newest Investigators and Awardees joining the Arc community! These exceptional scientists are pioneering research into critical questions about complex human disease. Welcome to: 🧑‍🔬Core
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Isha Jain
@ishahjain
Sep 8, 2024
🔥 We’re hiring! 🔥 Curious how cells adapt to the ever-changing environment? Our lab dives into oxygen sensing, vitamin metabolism, and beyond. We're looking for bold postdocs and staff scientists to push the boundaries! Join us!🔍🚀 #O2 #OxyJainLab #Vitamins #JoinOurTeam
Isha Jain
@ishahjain
May 22, 2024
We are hiring! Looking for passionate postdocs interested in working on oxygen and vitamin metabolism. Come join us in beautiful SF! Competitive salaries ($77-90K/yr) and benefits. Email [email protected]. Job descrip: shorturl.at/k8H1u @GladstoneInst @UCSF
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Isha Jain
@ishahjain
Mar 7, 2023
Our manuscript on hypoxic organ-specific fuel rewiring is out!! bitly.ws/BgTb and tweetorial below. @Cell_Metabolism @GladstoneInst And a great preview by Nick Denko et al bitly.ws/BgTc Stay tuned! Tomorrow, we turn the oxygen dial in the other direction!
Isha Jain
@ishahjain
Aug 26, 2022
New preprint from the lab! Led by rockstars @AyushDMidha + Yuyin Zhou! We were intrigued by dozens of epidemiological studies showing decreased metabolic syndrome and related phenotypes (dyslipidemia, hyperglycemia, obesity) in high altitude populations. bit.ly/3QMx5xD
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Isha Jain
@ishahjain
Aug 26, 2022
New preprint from the lab! Led by rockstars @AyushDMidha + Yuyin Zhou! We were intrigued by dozens of epidemiological studies showing decreased metabolic syndrome and related phenotypes (dyslipidemia, hyperglycemia, obesity) in high altitude populations. bit.ly/3QMx5xD
Isha Jain
@ishahjain
Dec 8, 2023
Our new paper: rb.gy/w1kvk0! @kirsten_chenx et al. looking at in vivo protein turnover vs O2. We confirm our previous work that C1 stability is O2-sensitive and nominate MYBBP1A as a mediator of the hyperoxia response (HIF for hyperoxia?) News: rb.gy/ammgdu
science.org
In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the...
Ambient oxygen levels alter protein turnover rates in tissues, revealing mediators of the hyperoxia response.
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Isha Jain
@ishahjain
Feb 24, 2023
Celebrating our two new manuscripts! Coming soon to a laptop near you!🥂🥳🎉 @WillRFlanigan @AyushDMidha @baik_alan @kirsten_chenx #Gladstone #UCSF #TurningtheOxygenDial
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