John Haughton MD, MS 🌻 (@doc4care) / X

John Haughton MD, MS 🌻

5,861 posts

John Haughton MD, MS 🌻

@doc4care

Protocols for inflammaging, longevity, long covid, mecfs/post infection care-Physician, Engineer. Chief Med Officer @RenegadeRes. Book appt 100apples.com

Annapolis, MD/Chautauqua,NY

Joined February 2011

Pinned
John Haughton MD, MS 🌻
@doc4care
Jan 20, 2024
Thread attached about how the “confused” immune system drives covid / long covid and some things that can be done now to help reverse it. #LongCovid #Treatment #Science
John Haughton MD, MS 🌻
@doc4care
Jan 20, 2024
Replying to @doc4care
1/n - Easier way to see TLR4 impact from viruses (TLR4 generally reacts to LPS and causes inflammation in sepsis. Some viruses - 4 shown in this paper “turn o TLR4 too”. (The confusion talked about in immune response in Covid?) k
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John Haughton MD, MS 🌻
@doc4care
Jun 30, 2023
Long Covid study shows TLR4 inflammation is at the core of the disease. Stop/Reverse to end the feedback loop causing ongoing downstream issues of inflammation and micro-clotting . Multi prong approach should work. Antiviral, TLR4 block, Fibrin break up, Probiotics… What Else?
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John Haughton MD, MS 🌻
@doc4care
May 4, 2024
🔔14 days of metformin lowers viral load and decreases clinical risk in acute and long covid vs placebo. 42% to 58% lower risk. Paxlovid doesnt do that. (Omicron variant, outpatient population. Likely via MTOR path). 🔔Makes sense to use metformin.
cidrap.umn.edu
Common diabetes drug lowers SARS-CoV-2 levels, clinical trial finds
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John Haughton MD, MS 🌻
@doc4care
Jan 24, 2024
1/2 Paper showing Metformin stops Spike driven inflammation. And shifts metabolism.
Rene Sugar
@renesugar
Jul 22, 2022
Metformin Suppresses Monocyte Immunometabolic Activation by #SARSCoV2 Spike Protein Subunit 1 frontiersin.org/articles/10.33… "SARS-CoV-2 spike protein induces a pro-inflammatory immunometabolic response in monocytes that can be suppressed by metformin"
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John Haughton MD, MS 🌻
@doc4care
Oct 24, 2024
Replying to @EricTopol
🔔. 1/4 of young marines had ongoing symptoms after covid. “Among 798 SARS-CoV-2 infected participants, 197 (24.7%) developed PASC. The most prevalent symptoms were loss of taste and/or smell (n = 82; 41.6%), shortness of breath (n = 74; 37.6%), and cough (n = 45; 22.8%)”
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John Haughton MD, MS 🌻
@doc4care
Nov 5, 2024
New study on changes in mitochondria in Long Covid. 1️⃣Increased ROS (super oxide dismutase 1), … note Taurine can help counteract 2️⃣changes in mito recycling (mitophagy) and 3️⃣a potential biomarker: lower amounts of circulating free mito dna… could be used as a test
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John Haughton MD, MS 🌻
@doc4care
Nov 26, 2023
Is Covid “slow sepsis” and is Long Covid “chronic sepsis”? Thoughts? Mitochondria article speaks to energy production & potential treatments to improve mito energy i sepsis. Mechanisms similar to LC/MECFS energy issues TLR4 turned on by LPS in sepsis and by S1 spike in Covid
htw
@heniek_htw
Nov 26, 2023
Restoring the infected powerhouse: #Mitochondrial quality control in #sepsis sciencedirect.com/science/articl…
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John Haughton MD, MS 🌻
@doc4care
Aug 19, 2022
Replying to @EricTopol @CellCellPress and 5 others
Interpretation: using saccharin or sucralose (Splenda) decreases the body.s ability to control sugar (glucose) within desired ranges. Blood sugar goes up more after eating if one uses either of those sweeteners for a couple of weeks. It happens due to gut bacteria changes.
John Haughton MD, MS 🌻
@doc4care
Nov 23, 2023
Taurine and mitochondria and effectiveness in patients with impaired cardiac function, 2 articles: 1) overview 2) clinical trial with ~25% increase in exercise capacity and cardiac output after 2 weeks of 500mg 3 times a day of taurine. #longcovid #mecfs
mdpi.com
The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant
Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first isolated in the...
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John Haughton MD, MS 🌻
@doc4care
Feb 22, 2024
Antivirals with anti-sars capabilities: We will finally know what works via trial for truvada. Truvada = $20/mo (and might work better) Paxlovid = $1300 for 2 weeks. Funded study of antiviral tx in long covid announced that tests truvada and will also look at marovirac
PolyBio
@polybioRF
Feb 22, 2024
Replying to @polybioRF
1. Icahn School of Medicine Mount Sinai: “A clinical trial of repurposed HIV antivirals in LongCOVID” 👉 Learn more here: polybio.org/projects/a-cli…
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John Haughton MD, MS 🌻
@doc4care
Sep 24, 2023
Naproxen is antiviral for SARSCov2. As is Allopurinol. Ethyrinic Acid (diuretic) is even more effective.
Rene Sugar
@renesugar
Nov 17, 2022
A new glimpse on the active site of #SARSCoV2 3CLpro, coupled with drug repurposing study link.springer.com/article/10.100… "Ethacrynic acid, naproxen, and allopurinol were shown as the most potent #SARSCoV2 3CLpro inhibitors, with IC50 values below 5 μM."
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John Haughton MD, MS 🌻
@doc4care
Nov 13, 2023
Metformin to improve CD4 exhaustion? Works to quiet inflammaging in Th17. Looks as if via pathway related to exhausted CD4 Tcells. Metformin enhances autophagy (recycling cell components) to limit inflammation. Looking at 30 to 60 y.o cells. Thoughts? cell.com/cell-metabolis…
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John Haughton MD, MS 🌻
@doc4care
Nov 9, 2024
Why Metformin Works Clue in Long Covid from PolyBio symposium. 🔔Those with breathlessness had increases in AKT MTOR path. 🔔Metformin (and Berberine) lower the AKT MTOR path activity. Ai explainer follows in next post. 1/2 @RenegadeRes @polybioRF @patientled
Patient-Led Research Collaborative
@patientled
Nov 8, 2024
Replying to @patientled @polybioRF and 4 others
So far: FACS of most subjects, just starting viral quantifications. That's the plan! But they have some completed work too. OLINK analysis in LC to connect symptoms to protein alterations quantifies 3000 proteins. Using this they connect profile to symptoms /38
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John Haughton MD, MS 🌻
@doc4care
Oct 5, 2023
Thread with explanation of immune system changes with viral attack. Uses a “beanbag” as immune system and “beans” as immune cells analogy that makes it easier to follow. Links to papers. Bottom line - we need to stop excess inflammation, it.s causing ongoing damage.
Reality Check Marker
@RealCheckMarker
Mar 23, 2023
Replying to @RealCheckMarker
ALL VIRAL INFECTIONS damage the immune system driving: - immune dysregulation - aging of naive t-cells - cellular senescence - increased risk for autoimmune diseases (diabetes, Alzheimer's) - oncogenic (cancer-causing) - opportunistic susceptibility to secondary infections.
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