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Anshul Kundaje
@anshulkundaje
Federally funded academic research is the innovation engine of the US economy. Reform is welcome. Destruction will have long term consequences.
Joined July 2006
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    Academic labs continue to lead on next generation tech dev for powering AI models for biology. The next big leap in models of gene regulation will be when they truly master the long range functional architecture of the genome. 1/
    How much of the human genome is essential? Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome. biorxiv.org/content/10.648… nature.com/articles/d4158…
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    I was on an H1B during my postdoc and research scientist years. I currently have exceptional PDs & staff scientists in my lab who are on H1Bs who have and are major contributors to the research output of the US. This is utterly stupid and idiotic. 1/
    SUMMARY OF H-1B EXECUTIVE ORDER - ENTRY BAN: No H-1B visa holder may enter the United States beginning Sunday September 21st, including current visa holders, unles they pay $100K to enter. - VISA FEE: New H-1B and H-1B extensions must pay 100K to be processed and 100K per year
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    Ok a few quick things. Most CS students who get into elite PhD programs in AI especially have already usually published multiple first author papers in "top" conferences. 1/
    i left my phd before joining openai working in industry demands more rigor – you don’t just need to convince reviewer 2 with a nice graph and an ego-cite, it better actually work if it’s underwriting billions in research investment not saying it always pans out that way in
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    Repeat after me: A reviewers role is POLITELY point out flaws in manuscripts and provide HELPFUL suggestions with the goal of helping authors IMPROVE their manuscript. The goal is not to find some random reason to reject the paper. And definitely not a license to be an ahole.
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    Goodbye green card! Hello US Citizenship! 🇺🇲🇺🇲🇺🇲 Attended the oath ceremony today with 375 other immigrants from 54 countries! What a wonderful melting pot. Arrived in 2001 as a student with hopes & dreams. This country gave me so much more than I expected. Thank you!
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    All postdocs in my lab are paid in the range of 85-95K. One of the reasons I can't go beyond is (reverse) equity concerns from HR. I would ideally pay them 105-115K. I think that's how much I could afford based on funding I can pull in & reducing lab size to a functional minimum.
    oh you’re hiring a grad student/postdoc? don’t be shy babe show us the salary
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    I'm making an open offer to any compbio grad students/postdocs who are aiming for faculty positions. If you have strong impactful research but no glam pubs & need someone to advocate for you, please get in touch. I promise u, I & a bunch of other faculty will strongly support u.
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    Excellent example of the core issue I was trying to get at wrt "virtual cells" - optimizing a prediction objective will not necessarily provide an accurate representation of physical or biological phenomena. It's extremely important to be very clear about this. 1/
    Can an AI model predict perfectly and still have a terrible world model? What would that even mean? Our new ICML paper formalizes these questions One result tells the story: A transformer trained on 10M solar systems nails planetary orbits. But it botches gravitational laws 🧵
    00:00
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    Oh nice! @Nature publishes another amazing advertisement for an amazing product masquerading as a scientific publication with no code, no model & a webserver that allows 10 queries at a time from a billion dollar company. But it's "gold" open access folks! Rejoice!
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    To all budding compbio & ML folks interested in bio: Don't just only run behind the latest ML model hype train. The greatest long run impact will come by really assimilating prior bio/compbio literature with the goal of really understanding strategies for how to model biology. 1/
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    For biological data, if you don't have deep expertise in this low value work called data cleaning, u r lacking a fundamental understanding of the idiosyncrasies of the data. Without this knowledge, it is impossible to seriously model data.
    Academia must be the only industry where extremely high-skilled PhD students spend much of their time doing low value work (like data cleaning). A 1st year management consultant outsources this immediately. Imagine the productivity gains if PhDs could focus on thinking
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    Postdocs deserve far more than we're usually paying them (especially those who end up at the big shot schools in the big shot towns and cities). Let's at least try to make an effort to do better before we lose them all to industry.
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    After 4 months of effort (2 months of very disciplined effort - 2 hours every night), I've finished my second manual scan of the entire GRCh38 human genome assembly + 900 DNase tracks (processed 3 different ways) + Input DNA tracks repeat masker. For what you ask?
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    Its finally happened! #Ascension (Figure 1: what @midjourney_ai claims one is supposed to feel like when promoted with tenure😆) 1/