Xiaojing Gao (@SynBioGaoLab) / X

Xiaojing Gao

416 posts

Xiaojing Gao

@SynBioGaoLab

Assistant Professor @ Stanford ChemE synthetic biology, biomolecular engineering synbiogaolab.bsky.social

Stanford, CA

Joined June 2019

Pinned
Xiaojing Gao
@SynBioGaoLab
Apr 3
"Engineering multiple levels of specificity in an RNA viral vector": Jenny finally led our covid-interrupted revision to completion. Thanks to the delay, we managed to incorporate our more recent RNA sensors and protease circuits into the RNA viral vectors
Xiaojing Gao
@SynBioGaoLab
May 29, 2020
Replying to @biorxivpreprint
Higher-order infinitesimal in light of the challenges we are all going through, but still happy that the preprint is out. Missing @ElowitzLab already. Kudos to Michaela and Matthew. Can't have found a more perfect collaborator than Lucy. Thank you all!
7.5K
Xiaojing Gao
@SynBioGaoLab
Apr 7, 2025
Editing 14 genes is no small feat, but I am not seeing enough evidence that "it is a dire wolf". Our community needs to communicate better to the public, now mor than ever, and imo that includes not exaggerating what we can deliver.
TIME
@TIME
Apr 7, 2025
TIME's new cover: The dire wolf is back after over 10,000 years. Here's what that means for other extinct species ti.me/4jlJB54
35K
Xiaojing Gao
@SynBioGaoLab
Mar 1, 2025
So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…
56K
Xiaojing Gao
@SynBioGaoLab
Oct 5, 2022
Our ADAR-based RNA sensors just came online! rdcu.be/cWX7o It allows you to express protein payloads in live cells in direct response to the presence of specific RNA transcripts. Also @EerikKaseniit, welcome to twitter.
Xiaojing Gao
@SynBioGaoLab
Feb 2, 2022
As we work towards DNA-free circuits, we realized we could use some new RNA sensors in living cells. So we built RADAR biorxiv.org/content/10.110… Congrats to Eerik, @katznoa1, @NatalieSKolber, @claytoncalli, and thanks to our plant biologist neighbors, Diego, Will, and @Sattely_lab
Xiaojing Gao
@SynBioGaoLab
Feb 2, 2022
As we work towards DNA-free circuits, we realized we could use some new RNA sensors in living cells. So we built RADAR biorxiv.org/content/10.110… Congrats to Eerik, @katznoa1, @NatalieSKolber, @claytoncalli, and thanks to our plant biologist neighbors, Diego, Will, and @Sattely_lab
biorxiv.org
Modular and programmable RNA sensing using ADAR editing in living cells
With the increasing availability of single-cell transcriptomes, RNA signatures offer a promising basis for targeting living cells. Molecular RNA sensors would enable the study of and therapeutic...
Xiaojing Gao
@SynBioGaoLab
Aug 13, 2019
Excited to announce the opening of my lab in Stanford ChemE next April! Tinkering with molecular circuits, viral vectors, and human cells for new biomedical solutions. Partners in crime wanted: students, postdocs, collaborators… More at
gaolab.blog
Gao Lab @ Stanford ChemE
Mammalian Synthetic Biology | Biomolecular Engineering
Xiaojing Gao
@SynBioGaoLab
Oct 17, 2022
Save the date: the 10th (!) Mammalian Synthetic Biology Workshop will be held on 6/22-6/23, 2023 at Stanford. For the very first time on the west coast of the US.
Xiaojing Gao
@SynBioGaoLab
May 23, 2024
Radar Tx is de-stealthed today! It's been so great working (or rather, tagging along) with co-founders, @EerikKaseniit, Sophia Lugo, and Jim Collins. We've assembled a stellar research team, forging ahead with new designs. We are still hiring more.
Startup launches with ‘RNA sensor’ technology from Stanford and MIT to better control mRNA therapies
From endpoints.news
31K
Xiaojing Gao
@SynBioGaoLab
May 5, 2024
Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.
39K
Xiaojing Gao
@SynBioGaoLab
Jan 23, 2024
When we talk about viral protease-based circuits, people wonder: "if it's meant as therapeutics, are you concerned about immunogenicity"? Now, in hDIRECT, we established control of cytokines using a human protease and its FDA-approved inhibitor: doi.org/10.1101/2024.0…
24K
Xiaojing Gao
@SynBioGaoLab
Mar 28, 2025
LIDAR is out! rdcu.be/efugD We've improved a lot, e.g., making MESA-like LIDAR work, RNAseq of on-/off-target editing, and optimizing RNA delivery. We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.
Xiaojing Gao
@SynBioGaoLab
May 5, 2024
Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.
20K
Xiaojing Gao
@SynBioGaoLab
Feb 17, 2022
This is now officially the first peer reviewed paper from our lab :) rdcu.be/cHcAc Did I mention that we are always looking for synbio-curious students and postdocs to develop/apply RELEASE, RADAR, and more tools down the pike?
Xiaojing Gao
@SynBioGaoLab
Oct 20, 2021
Wish you could control intercellular communication using protein circuits? First preprint from the lab! Proud of what @AlexVlahos, Jenny, and Carlos achieved, and how every lab member persisted through COVID. Also missing old colleagues @RonZhu2015, Lucy, and @ElowitzLab already.
Alex Vlahos (he/him)
@AlexVlahos
Oct 19, 2021
Excited to share the first work from my post-doc with @SynBioGaoLab at @Stanford_ChEMH. This pre-print highlights a platform to control the secretion and display of proteins that is compatible with pre-existing protein based synthetic circuits.
Xiaojing Gao
@SynBioGaoLab
Oct 5, 2022
And thank you, @GrinsteinJ for the nice interview with Eerik and Josh: Programmable RNA Sensors Enable Cell Editing and Therapeutic Intervention genengnews.com/gen-edge/progr… via @GENbio
Programmable RNA Sensors Enable Cell Editing and Therapeutic Intervention
From genengnews.com